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Effect of tranilast eyedrops in preventing posterior capsule opacification: Preliminary report

JOURNAL OF CATARACT AND REFRACTIVE SURGERY 1999年第10期25卷 1394-1399页

作者： Tobari, I Iwaki, Y Miyake, K Toho Univ Sch Med Dept Ophthalmol 2 Meguro Ku Tokyo 1530044 Japan

Purpose: To evaluate the effect of tranilast eyedrops in preventing fibrous opacification of the posterior lens capsule after cataract extraction and intraocular lens (IOL) implantation. Setting: The Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, and Shohzankai Medical Foundation, Miyake Eye Hospital, Nagoya, japan. Methods: This study comprised eyes having continuous curvilinear capsulorhexis and phacoemulsification/aspiration followed by implantation of a posterior chamber IOL in the capsular bag. In this prospective, randomized, controlled, and double-masked trial, tranilast 0.5% (Rizaben(R)) eyedrops (15 eyes) or its placebo eyedrops (20 eyes) were given 4 times a day for 3 months after surgery, An anterior eye segment analysis system (EAS 1000, Nidek Co., Ltd.) was used to evaluate the degree of fibrous posterior capsule opacification (PCO) 1 week and 1 and 3 months after surgery. Results: The mean PCO density in the tranilast group was 17.1 cct +/- 4.6 (SD), 20.0 +/- 3.6 cct, and 23.0 +/- 7.7 cct (cct = computer compatible tape) at 1 week and 1 and 3 months, respectively. in the control group, it was 18.2 +/- 5.3, 30.2 +/- 7.8, and 38.4 +/- 8.0 cct, respectively. There was a significant difference in the 1 and 3 month findings between the 2 groups (P < .001). Conclusion: Tranilast was effective in preventing fibrous PCO at an early postoperative stage. The possible mechanism of its effect may be prevention of collagen synthesis by minimizing transforming growth factor type P released during lens epithelial cell metaplasia. (C) 1999 ASCRS and ESCRS.

关键词：抗变态反应药/投药和剂量抗变态反应药/治疗应用白内障/病因学白内障/预防和控制双盲法晶体囊/药物作用晶体囊/病理学晶体植入眼内/副作用眼药水/投药和剂量眼药水/治疗应用超声乳化白内障吸除术/副作用前瞻性研究老年人女(雌)性人类男(雄)性中年人

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The impact of tranilast on restenosis after coronary angioplasty: The Second Tranilast Restenosis Following Angioplasty Trial (TREAT-2)

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AMERICAN HEART JOURNAL 2002年第3期143卷 506-513页

作者： Tamai, H Katoh, K Yamaguchi, T Hayakawa, H Kanmatsuse, K Haze, K Aizawa, T Nakanishi, S Suzuki, S Suzuki, T Takase, S Nishikawa, H Katoh, O Shiga Med Ctr Adults Dept Cardiol Shiga Japan

Background The Tranilast Restenosis Following Angioplasty Trial showed that oral administration of 600 mg/day of tranilast for 3 months markedly reduced the restenosis rate after percutaneous transluminal coronary angioplasty (PTCA) for de novo lesions. Methods We conducted the second multicenter, randomized, double-blinded placebo-controlled trial. A total of 297 patients with 329 lesions were randomly assigned to treatment with tranilast or a placebo for 3 months after successful PTCA for both de novo and restenotic lesions. Angiographic follow-up examination was clone at 3 months, and angiograms were interpreted with a quantitative approach. Results Two hundred thirty-nine lesions (72.6%) in 216 of the patients (72.7%) met the criteria and were included in the assessment of restenosis. Lesion restenosis was defined as a loss of 50% or more of the initial gain, and the restenosis rates were 18.8% in the tranilast group (n = 1 12) and 44.1% in the placebo group (n = 127;P = .00005). The restenosis rate, defined as a percent stenosis of greater than or equal to50% at follow-up examination, was also significantly lower in the tranilast group (25.9% versus 41.9%;P = .012). The numbers of restenotic lesions were 3 8 (33.9% of 1 12) in the tranilast group and 30 (23.6% of 127) in the placebo group. In restenotic lesions, the lesion restenosis rate was significantly lower in the tranilast subgroup (18.4% versus 53.3% with the first restenosis criterion;P = .004). Conclusion The oral administration of tranilast for 3 months markedly reduced the restenosis rate after PTCA, even in restenotic lesions.

关键词：投药口服血管成形术经腔经皮冠状动脉邻氨基苯甲酸类/治疗应用抗变态反应药/治疗应用消炎药非甾类/治疗应用冠心病/治疗冠状动脉再狭窄/预防和控制双盲法随访研究统计数据女(雌)性人类男(雄)性中年人

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Immune response to Trichinella spiralis larvae after treatment with the anti-allergic compound ketotifen

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PARASITOLOGY RESEARCH 2000年第3期86卷 232-238页

作者： Doligalska, M Univ Warsaw Dept Parasitol Inst Zool PL-00927 Warsaw Poland

Ketotifen was used as an anti-allergic agent to study the relationship between eosinophil-related responses and IgG1 and IgG2a antibody responses in BALB/c mice infected with Trichinella spiralis. The results showed that leukocyte and eosinophil numbers and interleukin-5 (IL-5) concentrations in the peritoneal fluid increased after exposure to nematodes and the increases were slightly greater in animals treated with ketotifen. A decreased concentration of eosinophil peroxidase and an elevation in IgG1 accompanied the muscle phase of infection, In mice treated with ketotifen, antibody-mediated recognition of muscle larvae was delayed. The retardation of IgG1 and IgG2a responses may have been responsible for the ineffective immune response against larvae migrating into the muscle, The activation of eosinophils was accompanied by changes in IL-5 concentration, but these changes were not associated with differences in protection against infection.

关键词：抗变态反应药/治疗应用抗体蠕虫/分析电泳聚丙烯酰氨凝胶酶联免疫吸附测定嗜酸细胞过氧化物酶嗜酸粒细胞增多/免疫学嗜酸细胞/酶学嗜酸细胞/免疫学免疫球蛋白G/分析白细胞介素5/代谢酮替芬/治疗应用白细胞计数小鼠近交BALBC 腹膜/细胞学过氧化物酶类/代谢大鼠 Wistar 毛线虫旋/免疫学旋毛虫病/药物疗法旋毛虫病/免疫学旋毛虫病/寄生虫学动物女(雌)性男(雄)性小鼠大鼠

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Design of peptides derived from anti-IgE antibody for allergic treatment

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1999年第15期9卷 2185-2188页

作者： Takahashi, M Ohgitani, Y Ueno, A Mihara, H Tokyo Inst Technol Fac Biosci & Biotechnol Dept Bioengn Midori Ku Yokohama Kanagawa 2268501 Japan Japan Sci & Technol Corp PRESTO Form & Funct Kyoto Japan

We have designed and synthesized peptides derived from an anti-IgE antibody which has a potential for the treatment of allergy. It was indicated that conformational restriction of peptide via an intramolecular disulfide bond improved the binding affinity for IgE and that the peptide might have an ability to inhibit the IgE-receptor interaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

关键词：抗变态反应药/化学合成抗变态反应药/治疗应用抗体抗独特型/化学抗体抗独特型/治疗应用药物设计超敏反应/药物疗法免疫球蛋白E/免疫学免疫球蛋白可变区/化学肽类/化学合成肽类/代谢肽类/治疗应用受体 IgE/拮抗剂和抑制剂人类

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Investigating patient experiences after a formulary change

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AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY 2000年第11期57卷 1052-1054页

作者： Jean, CD Triplett, JW Vet Affairs Med Ctr Pharm Serv 119 Miami FL 33125 USA

Management Case Studies describe approaches to real-life management problems in health systems. Each installment is a brief description of a problem and how it was dealt with. The cases are intended to help readers deal with similar experiences in their own work sites. Problem solving, not hypothesis testing, is emphasized. Successful resolution of the management issue is not a criterion for publication-important lessons can be learned from failures, too.

关键词：抗变态反应药/治疗应用西替利嗪/副作用西替利嗪/治疗应用氯雷他定/副作用氯雷他定/治疗应用病人满意度人类

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Inhibition of neointima formation by tranilast in pig coronary arteries after balloon angioplasty and stent implantation

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2000年第5期35卷 1331-1337页

作者： Ishiwata, S Verheye, S Robinson, KA Salame, MY de Leon, H King, SB Chronos, NAF Atlanta Cardiovasc Res Inst Atlanta GA 30342 USA Emory Univ Sch Med Dept Med Cardiol Andreas Gruentzig Cardiovasc Ctr Atlanta GA USA

OBJECTIVES We evaluated the effect of orally administered tranilast, N-(3,4-dimethoxycinnamoyl) anthranilic acid, on histologic and histomorphometric changes after angioplasty or stent implantation in pig coronary arteries. BACKGROUND Tranilast, which has antikeloid and antiallergic properties and therefore may modulate the fibrotic and inflammatory tissue responses to angioplasty and stenting, has been shown to inhibit angiographic restenosis in small clinical trials. However, its effect on histomorphometric changes in coronary arteries after angioplasty and stenting is unknown. METHODS Following initial pharmacokinetic studies in two pigs to determine desirable plasma levels of orally administered tranilast, 36 crossbred juvenile pigs were randomized to placebo or tranilast before undergoing balloon angioplasty in both the left anterior descending and left circumflex plus stent implantation in the right coronary artery. Oral tranilast was administered at 3 g/day starting 3 days before coronary injury and continued for 28 days until euthanasia. Injured vessels were harvested and sections analyzed by computer-assisted microscopic planimetry. RESULTS In balloon-injured vessels, tranilast was associated with a 37% reduction in neointimal area normalized to fracture length (0.47 +/- 0.01 vs. 0.74 +/- 0.03 mm;p < 0.001) and a 23% reduction in adventitial area normalized to vessel size (0.43 +/- 0.02 vs. 0.56 +/- 0.03;p = 0.003). In stented arteries, neointimal area normalized to injury score was 32% lower in the tranilast-treated group compared to control (1.94 +/- 0.17 vs. 2.86 +/- 0.29;p = 0.01). CONCLUSIONS In pig coronary arteries, tranilast was associated with a reduction in neointima formation and adventitial reaction after balloon injury. In stented vessels, tranilast was associated with a reduction in neointima formation normalized to injury score. (J Am Coil Cardiol 2000;35: 1331-7) (C) 2000 by the American College of Cardiology.

关键词：投药口服血管成形术气囊冠状动脉/副作用血管成形术气囊冠状动脉/仪器和设备抗变态反应药/血液抗变态反应药/药代动力学抗变态反应药/治疗应用消炎药非甾类/血液消炎药非甾类/药代动力学消炎药非甾类/治疗应用冠心病/血液冠心病/免疫学冠心病/病理学冠心病/治疗冠状血管/损伤疾病模型动物药物评价临床前纤维化炎症随机分配复发支架/副作用猪时间因素血管内膜/损伤伤口愈合/药物作用创伤和损伤/免疫学创伤和损伤/病理学创伤和损伤/预防和控制动物女(雌)性男(雄)性

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Gluma治疗牙本质过敏疗效观察

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现代口腔医学杂志 2004年第10期18卷 39-40页

作者：王丽敏许长春秦智慧内蒙古包头市蒙中医院 014040

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脱敏剂联合治疗牙本质过敏症疗效评价

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中国误诊学杂志 2006年第13期6卷 2508-2509页

作者：张敬马敏宁夏医学院附属医院口腔科宁夏银川750004

对我科2004—03采用GLUMA脱敏剂和氟保护漆联合治疗牙本质过敏症疗效评价如下。[第一段]

关键词：牙本质过敏/药物疗法氟/治疗应用抗变态反应药/治疗应用

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极固宁脱敏减少龋洞充填术后牙本质过敏的疗效观察

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中国误诊学杂志 2010年第1期10卷 49-50页

作者：姜书成高芹山东省威海市立医院口腔科 264200 山东省威海市立医院泌尿外科 264200

目的:了解极固宁脱敏对减轻龋洞充填术后牙本质过敏的效果。方法:将152例患者的280个患牙随机分为试验组和对照组,对照组备洞后常规充填,试验组备洞后先用极固宁脱敏,然后常规充填,比较两组的即刻和3个月后的牙本质过敏发生率。结果:试... 详细信息

目的:了解极固宁脱敏对减轻龋洞充填术后牙本质过敏的效果。方法:将152例患者的280个患牙随机分为试验组和对照组,对照组备洞后常规充填,试验组备洞后先用极固宁脱敏,然后常规充填,比较两组的即刻和3个月后的牙本质过敏发生率。结果:试验组的即刻和3个月后牙本质过敏发生率均低于对照组。结论:龋洞充填前先用极固宁脱敏能有效降低术后的牙齿过敏,值得临床推广。

关键词：抗变态反应药/治疗应用牙本质过敏/药物疗法

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扑尔敏辅助治疗急性气管-支气管炎的疗效观察

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中国误诊学杂志 2008年第19期8卷 4613-4614页

作者：张文健丁芸武警新疆边防总队医院机关门诊内科 830006

我院门诊2001-06/2006-10应用扑尔敏辅助治疗急性气管-支气管炎,效果良好,总结如下.

关键词：氯苯那敏/治疗应用抗变态反应药/治疗应用急性病气管炎/药物疗法支气管炎/药物疗法治疗结果人类

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