Fifty cases of surgical shock successfully treated with intravenous arterenol or intravenous neo-synephrine or both are presented. A satisfactory pressor response was obtained in 100 per cent of the arterenol group of...
详细信息
Fifty cases of surgical shock successfully treated with intravenous arterenol or intravenous neo-synephrine or both are presented. A satisfactory pressor response was obtained in 100 per cent of the arterenol group of thirty cases and significant arterial blood pressure elevations were obtained in 84 per cent of the neo-synephrine group. The relative merits of the two drugs as adjuvant therapy in the treatment of surgical shock are discussed and the indications for their respective uses are proposed. The results are sufficiently encouraging to justify further careful clinical observation and evaluation.
1. 1. The reduction of ocular tension effected by l-adrenalin in open-angle glaucoma is due to a lessened production of aqueous and not to any increased facility of drainage. 2. 2. The reduction of ocular tension by n...
详细信息
Cardiovascular drug interactions (beneficial and adverse) fall into 2 major categories: modification of drug metabolism and modification of drug action at the active site. In this review, particular emphasis is placed...
详细信息
Cardiovascular drug interactions (beneficial and adverse) fall into 2 major categories: modification of drug metabolism and modification of drug action at the active site. In this review, particular emphasis is placed on clinically important drug interactions which substantially influence the effectiveness or safety of [human] cardiovascular pharmacotherapy. Included are interactions involving cardiac glycosides, diuretics, adrenergic drugs, antihypertensive drugs, antiarrhythmics and anticoagulants.
SYNOPSIS Thirty-six patients participated in a double-blind, two-way crossover study of isometheptene (Octin) and placebo. Seventeen had a better response on isometheptene than on placebo. Placebo was superior to isom...
详细信息
SYNOPSIS Thirty-six patients participated in a double-blind, two-way crossover study of isometheptene (Octin) and placebo. Seventeen had a better response on isometheptene than on placebo. Placebo was superior to isometheptene in eight cases. Of 72 courses of treatment with each drug, isometheptene produced good or complete relief of pain in 30 courses of treatment (42%) while placebo produced a similar response in 21courses of treatment (29%) (p<0.05). When the severity of pain and the degree of relief were considered, the superiority of isometheptene did not reach statistical significance at the 5% level. Side effects due to isometheptene were few and mild or of moderate severity. Isometheptene may be an alternative treatment when ergotamine is contraindicated.
As expected on the basis of published research in both humans and animals, treatment with phentermine/fenfluramine lowers plasma 5-hydroxytryptophan whereas treatment with phentermine had no significant effect. In lig...
详细信息
As expected on the basis of published research in both humans and animals, treatment with phentermine/fenfluramine lowers plasma 5-hydroxytryptophan whereas treatment with phentermine had no significant effect. In light of these findings, future research should focus on mechanisms other than increased plasma 5-hydroxytryptophan to explain how fenfluramine increases the risk of primary pulmonary hypertension and valvular heart disease.
Study objective: After prolonged ventricular fibrillation (VF), precountershock cardiopulmonary resuscitation (CPR) will improve myocardial "readiness" for defibrillation compared with immediate defibrillati...
详细信息
Study objective: After prolonged ventricular fibrillation (VF), precountershock cardiopulmonary resuscitation (CPR) will improve myocardial "readiness" for defibrillation compared with immediate defibrillation. Methods: After 10 minutes of untreated VF, 32 swine (27 +/- 1 kg) were randomly assigned to receive immediate countershocks (DEFIB), CPR for 3 minutes followed by countershocks (CPR), or CPR for 3 minutes plus intravenous epinephrine followed by countershocks (CPR+EPI). VF waveform was evaluated by fast Fourier transformation. Results: VF amplitude and median frequency by fast Fourier transformation decreased during the untreated VF interval in all groups, and the median frequency subsequently increased during each minute of precountershock CPR. Although the VF median frequency in the 3 groups did not differ after 10 minutes of untreated VF (8.9 +/- 0.8 Hz versus 8.4 +/- 0.5 Hz versus 7.3 0.5 Hz, respectively), immediately before the first shock the VF median frequency was much lower in the DEFIB group than in either the CPR or CPR+EPI groups (8.9 +/- 0.8 Hz versus 13.1 +/- 0.8 Hz versus 13.8 +/- 0.9 Hz, respectively;P<.01). None of the 10 animals in the DEFIB group attained return of spontaneous circulation after the first set of shocks versus 5 of 10 animals in the CPR group and 6 of 12 animals in the CPR+EPI group (DEFIB versus each CPR group;P<.05). Cardiac output 1 hour after resuscitation was substantially worse in the DEFIB group than in the CPR or CPR+EPI groups (74 +/- 7 mL/kg per minute versus 119 +/- 7 mL/kg per minute versus 104 +/- 15 mL/kg per minute;P<.05). Conclusion: Precountershock CPR can result in substantial physiologic benefits compared with immediate defibrillation in the setting of prolonged VF. Moreover, these benefits can be attained with or without the addition of intravenous epinephrine.
暂无评论