Purpose To compare ultrahigh resolution optical coherence tomography (UHR OC T) technology to a standard resolution OCT instrument for the imaging of macula r hole pathology and repair; to identify situations where UH...
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Purpose To compare ultrahigh resolution optical coherence tomography (UHR OC T) technology to a standard resolution OCT instrument for the imaging of macula r hole pathology and repair; to identify situations where UHR OCT provides addi tional information on disease morphology, pathogenesis, and management; and to u se UHR OCT as a baseline for improving the interpretation of the standard reso lution images. Design Observational and interventional case series. Participants Twenty nine eyes of 24 patients clinically diagnosed with macular hole in at l east one eye. Methods A UHR OCT system has been developed and employed in a ter tiary care ophthalmology clinic. Using a femtosecond laser as the lowcoherence light source, this new UHR OCT system can achieve an unprecedented 3 μm axial resolution for retinal OCT imaging. Comparative imaging was performed with UHR OCT and standard 10 μm resolution OCT in 29 eyes of 24 patients with various stages of macular holes. Imaging was also performed on a subset of the populati on before and after macular hole surgery. Main outcome measures Ultrahigh and s tandard reso lution cross sectional OCT images of macular hole pathologies. R esults Both UHR OCT and standard resolution OCT exhibited comparable performan ce in differentiating various stages of macular holes. The UHR OCT provided imp roved imaging of finer intraretinal structures, such as the external limiting me mbrane and photoreceptor inner segment (IS) and outer segment (OS), and identifi cation of the anatomy of successful surgical repair. The improved resolution of UHR OCT enabled imaging of previously unidentified changes in photoreceptor mor phology associated with macular hole pathology and postoperative repair. Visuali zation of the junction between the photoreceptor IS and OS was found to be an im portant indicator of photoreceptor integrity for both standard resolution and U HR OCT images. Conclusions Ultrahigh resolution optical coherence tomography i mproves th
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