帕金森病(PD)是因中脑黑质纹状体多巴胺能神经元减少以及多巴胺–胆碱能系统失衡所致的一种常见的神经系统退行性疾病。帕金森病(PD)的临床表现不仅包括多种复杂的非运动症状(NMS),如自主神经功能障碍(AD)、认知功能下降(CD)和睡眠障碍等。其中,睡眠障碍是PD患者中最常见的NMS之一,其主要特征包括白天过度嗜睡(EDS)、快速眼动期行为障碍(RBD)以及昼夜节律紊乱,可能伴随或不伴随失眠。论文就帕金森病睡眠障碍相关标志物研究进展进行文献综述。Parkinson’s disease (PD) is a common neurodegenerative disorder caused by an imbalance of the dopamine-cholinergic system in the nigra striatum leading to reduced levels of dopaminergic neurons. The clinical manifestations of Parkinson’s disease (PD) include not only a variety of complex non-motor symptoms (NMS), such as autonomic dysfunction (AD), cognitive decline (CD), and park sleep. Among them, park sleep is one of the most common NMS in patients with PD, and its main features include excessive daytime sleepiness (EDS), rapid eye movement behavior disorder (RBD), and circadian rhythm disorder, which may or may not be accompanied by insomnia. The paper provides a literature review on the research progress of biomarkers related to park sleep in Parkinson’s disease.
心房心肌病是近年提出的新概念,是一个诸多临床因素损伤心房致其结构、电生理、功能改变的综合范畴。心房心肌病是发生心房颤动和卒中的心房基质,其与心房纤维化关系密切。早期识别心房心肌病患者并及早地进行综合治疗与管理,对于预防和控制房颤、卒中的发生至关重要。本文综合最新研究文献对心房心肌病相关标志物进行简要阐述。Atrial cardiomyopathy is a new concept put forward in recent years. It is a comprehensive category of structure, electrophysiology and function changes caused by many clinical factors. Atrial cardiomyopathy is the atrial matrix in which atrial fibrillation and stroke occur, and it is closely related to atrial fibrosis. Early identification of patients with atrial cardiomyopathy and early comprehensive treatment and management are very important for preventing and controlling the occurrence of atrial fibrillation and stroke. In this paper, based on the latest research literature, the related markers of atrial cardiomyopathy were briefly described.
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