Ribavirin administered as small-article aerosols had significant therapeutic effect in the treatment of viral respiratory infections induced by influenza virus. The preliminary experiment using ribavirin to treat infl...
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Ribavirin administered as small-article aerosols had significant therapeutic effect in the treatment of viral respiratory infections induced by influenza virus. The preliminary experiment using ribavirin to treat influenza infection in the squirrel monkey is encouraging. We expect to extend these experiments by initiating therapy at a later time to investigate the potential value of ribavirin in a clinical situation. Several derivatives of ribavirin are effective antiviral compounds. The tri-O-acetyl derivative appears to offer a potential advantage over ribavirin, although this cannot be stated with certainty since the data were obtained from separate experiments. Radiolabeling has been used as a means of measuring tissue concentration and clearance rates of various drugs. It is hoped that the use of labeled ribavirin and the tri-O-acetyl derivative will assist us in determining whether a depot of antiviral drug is created in pulmonary tissues after administration as a small-particle aerosol. These experiments are now in progress.
&NA;Benzimidavir (BW 1263W94, 1263W94, GW 1263) is a novel, orally bioavailable benzimidazole compound selected for development by Glaxo Wellcome for the treatment of cytomegalovirus (CMV) infection. Glaxo Wellcom...
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&NA;Benzimidavir (BW 1263W94, 1263W94, GW 1263) is a novel, orally bioavailable benzimidazole compound selected for development by Glaxo Wellcome for the treatment of cytomegalovirus (CMV) infection. Glaxo Wellcome investigated benzimidavir in the early stages of development in collaboration with the University of Michigan (Department of Medicinal Chemistry). Phase I/II clinical studies are underway in the EU and the *** its mechanism of action is not fully understood, benzimidavir appears to interfere with CMV DNAsynthesis by blocking a virus-specific process that is a novel antiviral *** possibly novel mechanism of action against CMV indicates that benzimidavir may be active against strains resistant to current therapies. Studies in volunteers have indicated good oral bioavailability and acceptable tolerance and it appears not to interfere with anti-HIV activity of antiretroviral drugs. Clinical trials will assess further the efficacy of benzimidavir for treatment of CMV infections.
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