In this talk, we discuss some discrete models in financial optimization. We first consider the single-factor mean-variance model with roundlots restriction. A branch-and-bound method based on Lagrangi
In this talk, we discuss some discrete models in financial optimization. We first consider the single-factor mean-variance model with roundlots restriction. A branch-and-bound method based on Lagrangi
新药的研发是一个高投入、低效率的工作,据统计,一个新药从筛选到成功上市,大约平均需要花费14年的时间,中间过程的花费则高达2.0-3.5亿美元,并且这一费用继续逐年增长。医药产业正面临着一个提高药物投放市场成功率的巨大压力。计算机辅助药物分子设计是减少新药研究经费、缩短筛选时间的有效途径,已经成为当前国内外的热门研究课题。计算机辅助药物设计方法可以分成两类,即基于小分子的药物设计(ligand-based drug design,LBDD)和基于受体生物大分子结构的药物设计(structure-based drug design,SBDD),分别称作间接药物设计和直接药物设计。SBDD根
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