Objective To investigate the effect of bolus dose remifentanil and propofol on tracheal intubating conditions and hemodynamic changes to laryngoscopy and tracheal intubation during induction of *** Sixty ASA physical ...
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Objective To investigate the effect of bolus dose remifentanil and propofol on tracheal intubating conditions and hemodynamic changes to laryngoscopy and tracheal intubation during induction of *** Sixty ASA physical status I～II patients were administered propofol 2 mg/kg and vecuronium 0.12 mg·kg-1·h-1 and remifentanil 1 μg/kg（groupⅠ）, remifentanil 2 μg/kg（group Ⅱ） or remifentanil 3 μg/kg（group Ⅲ） as a rapid bolus *** condition and hemodynamic changes in intra-tracheal intubation were observed. Intubating conditions was assessed using a four-point scoring *** Tracheal intubation was successful in all *** or good intubation conditions were observed in only 40% in group Ⅰcompared with group Ⅱ and Ⅲ（P < 0.05）.MAP decreased in three groups after induction of anesthesia（P <0.05 or P <0.01）,HR decreased in group Ⅱ and Ⅲ after induction of anaesthesia（P <0.05）.MAP and HR in group Ⅰ and Ⅱ increased significantly after tracheal intubation（P <0.05 or P <0.01）.There were little changes in MAP and HR in group Ⅲ（P >0.05）.The incidence of hypotension in group Ⅲ increased significantly than the group Ⅱ（P <0.05）;but the incidence of bradycardia was no significant difference between the group Ⅱ and Ⅲ（P >0.05）. Conclusion Remifentanil（3 μg/kg） administered with propofol provides acceptable tracheal intubating conditions,and completely inhibites the increase of HR and MAP associated with intubation.
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