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FREE RHEUMATOID-FACTOR IN DENTAL PERIAPICAL LESIONS AND GINGIVAE OF PATIENTS WITH RHEUMATOID DISEASE

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 1975年第3期4卷 121-124页

作者： MALMSTROM, M JOKINEN, EJ UNIV HELSINKI INST DENTDEPT ORAL SURGHELSINKI 10FINLAND UNIV HELSINKI DEPT SEROL & BACTERIOLHELSINKIFINLAND RHEUMATISM FDN HOSP HEINOLAFINLAND

To determine whether evidence of rheumatoid inflammation, in the form of free rheumatoid factor, might be found in the teeth-supporting tissues of patients with known rheumatoid disease, tissues from the dental periapical lesions of one group of 50 rheumatoid and 23 control patients, and from the marginal gingivae of a second group of 58 rheumatoid patients were examined by the direct immunofluorescence technique that employed fluroesceinisothiocyanate (FITC)-labelled aggregated human IgG. The gingival tissues contained no free rheumatoid factor. Free rheumatoid factor-producing plasma cells were, however, detected in the dental periapical lesions of 3 of the 50 rheumatoid patients, i.e. in 6%, and in 1 of the control patients i.e., in 4%. This control patient had suffered from nephritis 10 months prior to the investigation. Because free rheumatoid factor did occur, albeit infrequently, in the dental periapical lesions of rheumatoid patients, a search for IgG rheumatoid factor, known to occur in greater abundance than the IgM type although "hidden", was indicated.

关键词：关节炎类风湿/并发症牙龈/代谢根尖周脓肿/代谢牙周疾病/病因学牙周疾病/代谢浆细胞/代谢风湿性疾病/并发症风湿性疾病/代谢类风湿因子/代谢脊柱炎强直性/并发症成年人女(雌)性人类男(雄)性中年人

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ELECTRON-MICROSCOPIC AUTORADIOGRAPHIC AND ELECTRON-MICROSCOPIC IMMUNOHISTOCHEMICAL STUDIES ON ANTI-HPO ANTIBODY-PRODUCING CELLS

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EXPERIMENTAL CELL RESEARCH 1975年第2期95卷 287-294页

作者： ITOH, G HIRABAYASHI, N KURASHINA, M NAGOYA UNIV SCH MEDDEPT PATHOL 165 TSURUMA CHONAGOYAJAPAN

The secondary immune responses in mouse popliteal lymph nodes to horseradish peroxidase (HPO) were studied by a combination of electron microscopic autoradiography and electron microscopic immunohistochemistry in order to clarify the relationship between antibody-producing and DNA-synthesizing capacities of the plasmacytic series. The anti-HPO antibody-containing cells, which increased in number 72 h after the secondary antigenic stimulation, were mainly immunoblasts and immature plasma cells. Immunoblasts containing anti-HPO antibody incorporated [ 3 H]thymidine more actively than did immature plasma cells containing anti-HPO antibody. In 144 h after the secondary antigenic stimulation, antibody containing cells consisted mainly of mature plasma cells and immature plasma cells. Immature plasma cells containing the anti-HPO antibody incorporated a little [ 3 H]thymidine, but mature plasma cells containing anti-HPO antibody did not incorporate any [ 3 H]thymidine.

关键词：抗体生成抗体生成细胞/免疫学抗体生成细胞/代谢抗体生成细胞/超微结构细胞核仁/超微结构细胞核/超微结构染色质/超微结构细胞质/超微结构 DNA/生物合成内质网/超微结构荧光抗体技术辣根过氧化物酶/免疫学免疫记忆免疫学技术显微镜检查电子过氧化物酶类/免疫学浆细胞/免疫学浆细胞/代谢浆细胞/超微结构核糖体/超微结构胸苷/代谢动物小鼠

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A histological and immunohistochemical study of the humoral immune system of the lungs in young thoroughbred horses

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JOURNAL OF COMPARATIVE PATHOLOGY 1999年第4期120卷 347-356页

作者： Blunden, AS Gower, SM Anim Hlth Trust Ctr Prevent Med Newmarket CB8 7UU Suffolk England

Lungs were obtained from 16 Thoroughbred horses, aged 1 day to 2 years, which had died or been humanely killed for reasons unrelated to disease of the lower respiratory tract. The lungs were then subjected to a histological and immunohistochemical examination of the humoral immune system. At birth there was no evidence of organized lymphoid tissue, and lymphocytes and plasma cells were virtually absent in all tissue compartments in the first week of life. However, by 12 weeks;foals exhibited well developed bronchus-and bronchiole-associated lymphoid tissue, but this had regressed progressively at and 2 years of age. Plasma cells were present in large numbers in the walls of bronchi and bronchioles in foals aged 8 to 12 weeks. IgA-producing plasma cells were common in the lower respiratory tract of these young horses, in addition to IgG- and Ig;IgM-producing plasma cells. (C) 1999 W.B. Saunders Company Limited.

关键词：衰老/免疫学动物新生抗体生成/免疫学支气管/细胞学马/免疫学免疫球蛋白A/代谢免疫球蛋白G/代谢免疫球蛋白M/代谢免疫组织化学肺/细胞学肺/免疫学肺/代谢淋巴组织/细胞学浆细胞/细胞学浆细胞/代谢动物女(雌)性男(雄)性

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Amplification of IgG VH and VL (Fab) from single human plasma cells and B cells

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NUCLEIC ACIDS RESEARCH 2000年第20期28卷 E85页

作者： Coronella, J. A. Telleman, P. Truong, T. D. Ylera, F. Junghans, R. P. Harvard Univ Sch Med Harvard Inst Human Genet Biotherapeut Dev Lab Boston MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA 02215 USA

Amplification of human immunoglobulin has many potential applications such as analysis of clonality, isolation of immunogenic antigens and antigen-specific immunotherapy. Here we describe a method for amplification of human immunoglobulin heavy and light chains from single B lymphocytes or plasma cells. Cells are isolated by FACS, and Ig is amplified by semi-nested RT-PCR. The method is versatile, sensitive and reliable: it provides appropriately paired heavy and light chains, requiring as little as 2 days to produce amplified Fab DNA from human tissues.

关键词： B淋巴细胞/细胞学 B淋巴细胞/免疫学 B淋巴细胞/代谢碱基序列乳腺肿瘤/免疫学细胞分离 DNA引物/遗传学设备污染流式细胞术免疫球蛋白Fab片段/遗传学免疫球蛋白碎片/遗传学免疫球蛋白G/遗传学免疫球蛋白重链/遗传学免疫球蛋白可变区/遗传学免疫球蛋白κ链/遗传学免疫球蛋白λ链/遗传学器官特异性腭扁桃体/免疫学浆细胞/细胞学浆细胞/免疫学浆细胞/代谢聚合酶链反应/方法 RNA 信使/分析 RNA 信使/遗传学结果可重复性逆转录聚合酶链反应敏感性与特异性序列比对底物特异性时间因素肿瘤细胞培养的女(雌)性人类

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A monoclonal antibody (MUM1p) detects expression of the MUM 1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells

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BLOOD 2000年第6期95卷 2084-2092页

作者： Falini, B Fizzotti, M Pucciarini, A Bigerna, B Marafioti, T Gambacorta, M Pacini, R Alunni, C Natali-Tanci, L Ugolini, B Sebastiani, C Cattoretti, G Pileri, S Dalla-Favera, R Stein, H Univ Perugia Inst Hematol I-06100 Perugia Italy Univ Perugia Inst Internal Med I-06100 Perugia Italy Osped Niguarda Ca Granda Inst Pathol Milan Italy Univ Bologna Inst Pathol Bologna Italy Columbia Univ Coll Phys & Surg Dept Pathol New York NY 10032 USA Benjamin Franklin Univ Inst Pathol Berlin Germany

A new monoclonal antibody (MUM1p) was used to study the cell/tissue expression of human MUM1/IRF4 protein, the product of the homologous gene involved in the myeloma-associated t(6;14) (p25;q32), MUM1 was expressed in the nuclei and cytoplasm of plasma cells and a small percentage of germinal center (GC) B cells mainly located in the "light zone." Its morphologic spectrum ranged from that of centrocyte to that of a plasmablast/plasma cell, and it displayed a phenotype (MUM1(+)/Bcl-6(-)/Ki67(-)) different from that of most GC B cells (MUM1(-)/Bcl-6(+)/Ki57(+)) and mantle B cells (MUM1(-)/Bcl-6(-)/Ki67(-)). Polymerase chain reaction (PCR) analysis of single MUM1(+) cells isolated from GCs showed that they contained rearranged Ig heavy chain genes with a varying number of VH somatic mutations. These findings suggest that these cells may represent surviving centrocytes and their progeny committed to exit GC and to differentiate into plasma cells. MUM1 was strongly expressed in lymphoplasmacytoid lymphoma, multiple myeloma, and approximately 75% of diffuse large B-cell lymphomas (DLCL-B), Unlike normal GC B cells, in which the expression of MUM1 and Bcl-6 were mutually exclusive, tumor cells in approximately 50% of MUM1(+) DLCL-B coexpressed MUM1 and Bcl-6, suggesting that expression of these proteins may be deregulated, In keeping with their proposed origin from GC B cells, Hodgkin and Reed-Sternberg cells of Hodgkin's disease consistently expressed MUM1. MUM1 was detected In normal and neoplastic activated T cells, and its expression usually paralleled that of CD30. These results suggest that MUM1 is involved in the late stages of B-cell differentiation and in T-cell activation and is deregulated in DLCL-B. (C) 2000 by The American Society of Hematology.

关键词：抗体单克隆 B淋巴细胞/代谢印迹法蛋白质细胞系 DNA结合蛋白质类/代谢表位 HeLa细胞免疫球蛋白可变区/代谢免疫组织化学干扰素调节因子类 Jurkat细胞淋巴结/代谢淋巴瘤/代谢多发性骨髓瘤/代谢浆细胞/代谢重组融合蛋白质类/代谢 T淋巴细胞/代谢时间因素转录因子/代谢转染肿瘤标记生物学/代谢人类

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浆细胞膜糖蛋白-1基因与肥胖、糖尿病关系的群体水平研究

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中国医师杂志 2010年第12期12卷 1616-1619页

作者：周媛媛钱凤娟陈杰田振华沈捷南京市中医院ICU 南京210001 江苏省常州市第一人民医院南京市胸科医院山东省立医院江苏省人民医院HLA实验室

目的研究肥胖、2型糖尿病、胰岛素抵抗与候选基因PC-1之间的关系.方法运用PCR-RFLP技术分析53例正常对照者,105例肥胖患者,63例糖尿病非肥胖患者,114例肥胖伴糖尿病患者PC-1基因编码区K121Q多态性.结果 Q等位基因频率在正常对照、肥... 详细信息

目的研究肥胖、2型糖尿病、胰岛素抵抗与候选基因PC-1之间的关系.方法运用PCR-RFLP技术分析53例正常对照者,105例肥胖患者,63例糖尿病非肥胖患者,114例肥胖伴糖尿病患者PC-1基因编码区K121Q多态性.结果 Q等位基因频率在正常对照、肥胖人群、糖尿病非肥胖人群、糖尿病伴肥胖人分别为3%,18%,4%和30%.与正常对照组比较,OB组、OB＋H组、OB＋I组、OB＋L组、OB＋HIL组的相对危险性（RR）分别为4.26,4.12,7.36,5.15,9.70;与单纯糖尿病组比较,DM＋OB组、DM＋OBH组、DM＋OBI组、DM＋OBL组、DM＋OBHIL组的RR分别5.32,7.37,12.07,8.53,13.50.结论 PC-1 Q等位基因与肥胖、肥胖2型糖尿病、胰岛素抵抗的发生呈正相关,它参与了部分中国人肥胖、2型糖尿病、胰岛素抵抗的发生.

关键词：浆细胞/代谢糖蛋白类/代谢肥胖症/代谢/病因学糖尿病/代谢/病因学

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CD34 expression in calcifying fibrous pseudotumours

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HISTOPATHOLOGY 2000年第2期36卷 183-184页

作者： Zámecnik, M Michal, M Boudova, L Sulc, M Postgrad Med Sch Dept Pathol Bratislava Slovakia Fac Hosp Dept Pathol Plzen Czech Republic Gen Hosp Dept Pathol Chomutov Czech Republic

Supports B. Weynand and colleagues' description of the CD34 expression in calcifying fibrous pseudotumor in the peritoneum. CD34-positive cell differentiation toward CD34-negative collagenous fibroblasts.

关键词：抗原 CD34/分析抗原 CD34/生物合成钙质沉着症/代谢钙质沉着症/病理学肉芽肿浆细胞/代谢肉芽肿浆细胞/病理学免疫组织化学成年人老年人女(雌)性人类男(雄)性中年人

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Sarcomatoid variant of anaplastic large cell lymphoma with cytoplasmic ALK and α-smooth muscle actin expression:: A mimic of inflammatory myofibroblastic tumor

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AMERICAN JOURNAL OF PATHOLOGY 2001年第1期159卷 383-384页

作者： Suzuki, R Seto, M Nakamura, S Nakagawa, A Hara, K Takeuchi, K Aichi Canc Ctr Nagoya Aichi 464 Japan Aichi Med Univ Nagakute Aichi 48011 Japan Univ Tokyo Tokyo Japan

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