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检索条件"主题词=瓜氨酸/代谢"
15 条 记 录,以下是1-10 订阅
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L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
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JOURNAL OF BIOLOGICAL CHEMISTRY 2001年 第1期276卷 40-47页
作者: Heller, R Unbehaun, A Schellenberg, B Mayer, B Werner-Felmayer, G Werner, ER Univ Jena Ctr Vasc Biol & Med D-99089 Erfurt Germany Karl Franzens Univ Graz Inst Pharmacol & Toxicol A-8010 Graz Austria Univ Innsbruck Inst Med Chem & Biochem A-6020 Innsbruck Austria
Ascorbic acid has been shown to stimulate endothelial nitric oxide (NO) synthesis in a time- and concentration-dependent fashion without affecting NO synthase (NOS) expression or L-arginine uptake. The present study i... 详细信息
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A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase
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JOURNAL OF BIOLOGICAL CHEMISTRY 2001年 第2期276卷 1233-1243页
作者: Santolini, J Adak, S Curran, CML Stuehr, DJ Cleveland Clin Fdn Lerner Res Inst Dept Immunol Cleveland OH 44195 USA
After initiating NO synthesis a majority of neuronal NO synthase (nNOS) quickly partitions into a ferrous heme-NO complex. This down-regulates activity and increases enzyme K-m,K-O2. To understand this process, we dev... 详细信息
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Characterization of the roles of the 594-645 region in human endothelial nitric-oxide synthase in regulating calmodulin binding and electron transfer
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第17期275卷 13155-13163页
作者: Chen, PF Wu, KK Univ Texas Hlth Sci Ctr Sch Med Dept Internal MedDiv Hematol Houston TX 77225 USA Univ Texas Hlth Sci Ctr Dept Internal Med Vasc Biol Res Ctr Houston TX 77225 USA
It has been postulated that a segment (residues 594-645) inserted in the FMN subdomain of human endothelial nitric oxide synthase (eNOS) plays a crucial role in controlling Ca2+-dependent CaM binding for eNOS activity... 详细信息
来源: 评论
Kinetics of the arginine metabolism of malolactic wine lactic acid bacteria Lactobacillus buchneri CUC-3 and Oenococcus oeni Lo111
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JOURNAL OF APPLIED MICROBIOLOGY 2000年 第3期89卷 547-552页
作者: Mira de Orduña, R Liu, SQ Patchett, ML Pilone, GJ Massey Univ Inst Mol Biosci Palmerston North New Zealand New Zealand Dairy Res Inst Palmerston North New Zealand
The excretion of citrulline, a precursor of carcinogenic ethyl carbamate, formed from arginine degradation by malolactic bacteria in wine is of toxicological concern. The arginine metabolism of resting cells of Lactob... 详细信息
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Modulation of nitric-oxide synthase by nicotine
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2000年 第2期295卷 601-606页
作者: Tonnessen, BH Severson, SR Hurt, RD Miller, VM Mayo Clin & Mayo Fdn Dept Surg Rochester MN 55905 USA Mayo Clin & Mayo Fdn Dept Internal Med Rochester MN 55905 USA Mayo Clin & Mayo Fdn Nicotine Res Ctr Rochester MN 55905 USA Mayo Clin & Mayo Fdn Dept Physiol & Biophys Rochester MN 55905 USA
Effects of nicotine on arterial endothelium-dependent relaxations mediated by nitric oxide are controversial. Experiments were designed to test the hypothesis that nicotine can directly alter activity of endothelial n... 详细信息
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Unique gonococcal phenotype associated with asymptomatic infection in men and with erroneous diagnosis of nongonococcal urethritis
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JOURNAL OF INFECTIOUS DISEASES 2000年 第3期181卷 1044-1048页
作者: Whittington, WLH Holmes, KK Harborview Med Ctr Div Infect Dis Seattle WA 98104 USA Univ Washington Sch Med Dept Med Seattle WA 98195 USA Univ Washington Sch Med Ctr AIDS & STD Seattle WA 98195 USA Publ Hlth Seattle & King Cty Seattle WA USA
The percentage of gonococcal isolates in King County, Washington, requiring citrulline and uracil (CU auxotype) increased from 1.6% in 1986 to 16.5% in 1997. Among men, urethral infection with the CU auxotype (n = 93)... 详细信息
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The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes
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MOLECULAR PHARMACOLOGY 2000年 第5期58卷 1026-1034页
作者: Boer, R Ulrich, WR Klein, T Mirau, B Haas, S Baur, I Byk Gulden Lomberg GmbH D-78467 Constance Germany
We have investigated various nitric oxide (NO) synthase inhibitors for their affinity and selectivity toward the three human isoenzymes in radioligand binding experiments. Therefore, we developed the new radioligand [... 详细信息
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Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor: binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation. (vol 275, pg 5291, 2000)
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第21期275卷 16400-16400页
作者: Golser, R Gorren, ACF Leber, A Andrew, P Habisch, HJ Werner, ER Schmidt, K Venema, RC Mayer, B InstitutfürPharmakologieundToxikologie Karl-Franzens-UniversitätGrazUniversitätsplatz2A-8010GrazAustria.
Endothelial nitric-oxide synthase (type III) (eNOS) was reported to form an inhibitory complex with the bradykinin receptor B2 (B2R) from which the enzyme is released in an active form upon receptor activation (Ju, H.... 详细信息
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Na+/Ca2+ exchange facilitates Ca2+-dependent activation of endothelial nitric-oxide synthase
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JOURNAL OF BIOLOGICAL CHEMISTRY 1999年 第41期274卷 29529-29535页
作者: Teubl, M Groschner, K Kohlwein, SD Mayer, B Schmidt, K Karl Franzens Univ Graz Inst Pharmakol & Toxikol A-8010 Graz Austria Graz Univ Technol Inst Biochem & Lebensmittelchem A-8010 Graz Austria
Recent evidence suggests the expression of a Na+/ Ca2+ exchanger (NCX) in vascular endothelial cells, To elucidate the functional role of endothelial NCX, we studied Ca2+ signaling and Ca2+-dependent activation of end... 详细信息
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L-ascorbic acid potentiates nitric oxide synthesis in endothelial cells
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JOURNAL OF BIOLOGICAL CHEMISTRY 1999年 第12期274卷 8254-8260页
作者: Heller, R Münscher-Paulig, F Gräbner, R Till, U Univ Jena Ctr Vasc Biol & Med D-99089 Erfurt Germany
Ascorbic acid has been shown to enhance impaired endothelium-dependent vasodilation in patients with atherosclerosis by a mechanism that is thought to involve protection of nitric oxide (NO) from inactivation by free ... 详细信息
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