检索结果-内蒙古大学图书馆

A controlled trial of topical nitroglycerin in a new Zealand white rabbit model of brown recluse spider envenomation

引用

ANNALS OF EMERGENCY MEDICINE 2001年第2期37卷 161-165页

作者： Lowry, BP Bradfield, JF Carroll, RG Brewer, K Meggs, WJ E Carolina Univ Sch Med Dept Emergency Med Greenville NC 27858 USA

Study objectives: Topical nitroglycerin has been reported to prevent skin necrosis from brown recluse spider bites, but this has never been scientifically tested. This study attempts to assess the effects of topical nitroglycerin on experimental Loxosceles reclusa envenomations. Methods: We performed a randomized, blinded, controlled study in an animal care facility. Twenty-four New Zealand white rabbits were experimentally envenomated by means of subcutaneous injection with 20 mug of brown recluse spider venom. Rabbits were randomized to 1 of 2 experimental groups. The treatment group received 1 in of 2% topical nitroglycerin ointment every 6 hours for 3 days applied directly to the envenomation site. The control group received the vehicle without nitroglycerin. Gross examination of the lesions and measurements of the areas of the lesions were made daily. Creatine phosphokinase (CPK), blood urea nitrogen, creatinine, hemoglobin, and hematocrit levels were measured on days 0, 5, and 10. Lesions were excised after 10 days and examined by a blinded pathologist, who measured the area of necrosis and quantified inflammation and edema using a standard wound-healing score. For all values, mean values plus SD were determined. All comparisons made over multiple time points were assessed for significance by using a repeated-measures analysis of variance followed by Fisher least significant difference and Scheffe post hoc comparisons. A P value of .05 or less was used to determine significance. The Student's t test was used to compare the means of single measures. Significance was determined by using 95% confidence intervals. Comparisons of total area of necrosis were made with the nonparametric Mann-Whitney U test because of the heavy positive skew of the data. Results: Skin necrosis developed in all animals. Mean values of the lesion area were not significantly different over time between the 2 groups of animals. At day 10, the median area of necrosis was 22.3 cm(2) for the

关键词：投药皮肤方差分析蜘蛛毒中毒/血液蜘蛛毒中毒/分类蜘蛛毒中毒/药物疗法蜘蛛毒中毒/病理学血尿素氮肌酸激酶/血液肌酸酐/血液疾病模型动物用药计划表药物评价临床前血细胞比容血红蛋白类/分析炎症坏死硝酸甘油/治疗应用软膏随机分配疾病严重程度指数单盲法统计学非参数时间因素血管舒张药/治疗应用伤口愈合/药物作用动物兔

来源：评论

学校读者我要写书评

暂无评论

Effect of a three month course of ciprofloxacin on the late prognosis of reactive arthritis

引用

ANNALS OF THE RHEUMATIC DISEASES 2003年第9期62卷 880-884页

作者： Yli-Kerttula, T Luukkainen, R Yli-Kerttula, U Möttönen, T Hakola, M Korpela, M Sanila, M Uksila, J Toivanen, A Univ Turku Satalinna Hosp Dept Med SF-20500 Turku Finland Univ Turku Satalinna Hosp Dept Med Microbiol SF-20500 Turku Finland Tampere Univ Hosp Dept Med Rheumatol Sect Tampere Finland Jyvaskyla Cent Hosp Jyvaskyla Finland

Background: The value of antibiotics in the treatment of reactive arthritis (ReA) is still controversial. Objectives: To analyse the long term outcome of patients with ReA, treated with a three month course of ciprofloxacin or placebo. Methods: Patients who had had ReA and had participated in a double blind, placebo controlled trial on the effectiveness of ciprofloxacin 4-7 years earlier were invited to a clinical examination. Of the 71 patients who were included in the original study, 53 agreed to visit the clinic for an examination. Twenty six of 53 patients had originally received ciprofloxacin and 27 had belonged to the placebo group. Of these, 20 in the ciprofloxacin and 25 in the placebo group were HLA-B27 positive. Results: 11/27 (41%) patients in the original placebo group had now developed chronic rheumatic disease, as compared with only 2/26 (8%) patients originally treated with ciprofloxacin (p=0.006). Two patients who originally had received placebo, none in the ciprofloxacin group had developed ankylosing spondylitis, and three patients in the original placebo group, none in the ciprofloxacin group had recurrent anterior uveitis. The same tendency was seen when several different measures were analysed. Of the patients with chronic spondyloarthropathy, 10 in the placebo and none in the ciprofloxacin group were HLA-B27 positive. Conclusion: Analysis 4-7 years after the initial ReA suggests that a three month course of antibiotics in the acute phase may have a beneficial effect on the long term prognosis.

关键词：急性病抗感染药/治疗应用关节炎反应性/药物疗法慢性病环丙沙星/治疗应用双盲法用药计划表随访研究 HLA-B27抗原/血液预后风湿性疾病/免疫学风湿性疾病/预防和控制治疗结果成年人老年人女(雌)性人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

Does size matter? Association between number of patients treated and patient outcome in metastatic testicular cancer

引用

JOURNAL OF THE NATIONAL CANCER INSTITUTE 1999年第10期91卷 816-818页

作者： Feuer, EJ Sheinfeld, J Bosl, GJ NCI Div Canc Control & Poplat Sci Bethesda MD 20892 USA Mem Sloan Kettering Canc Ctr Dept Surg Urol Serv New York NY 10021 USA Mem Sloan Kettering Canc Ctr Dept Med New York NY 10021 USA

Editorial. Discusses the association between patient outcome and volume in breast cancer and operative mortality for major cancer surgery. Results of the Swedish Norwegian Testicular Cancer Project from 1981 to 1968; ... 详细信息

关键词：抗肿瘤药/投药和剂量癌症医护设施/标准癌症医护设施/利用临床方案用药计划表欧洲医院死亡率结果评价(卫生保健) SEER规划存活率分析睾丸肿瘤/药物疗法睾丸肿瘤/死亡率睾丸肿瘤/外科学睾丸肿瘤/治疗美国/流行病学人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

Ichthyosis cribriformis: A new entity?

引用

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2008年第3期58卷 505-507页

作者： de Almeida, Hiram Larangeira, Jr. Happle, Rudolf Blume-Peytavi, Ulrike de Castro, Luis Antnic Suita Catholic & Fed Univ Pelotas Pelotas Brazil Univ Marburg D-35032 Marburg Germany Charite Dept Dermatol & Allergy D-13353 Berlin Germany EMBRAPA CPA CT Electron Microscopy Lab Pelotas Brazil

A 22-year-old woman had an unusual congenital skin disorder in the form of ichthyosis characterized by innumerable keratotic plugs, resulting in a peculiar sievelike appearance. On histopathologic examination the epidermis showed a pronounced orthohyperkeratosis. The keratotic plugs seemed to emerge from the infundibular region of hair follicles. immunohistochemical characterization revealed a normal keratin and filaggrin expression. Oral treatment with isotretinoin resulted in a reduction of the hyperkeratosis. Because we could not find any previously reported similar case, we propose the new name "ichthyosis cribriformis," which means "sievelike ichthyosis.".

关键词： Administration Oral Adult Dermatologic Agents Dose-Response Relationship Drug 投药口服成年人皮肤科用药剂量效应关系药物用药计划表鳞癣异维A酸 Dose-response relationship Pharmaceutical Preparations Hair Follicle Adults Skin Abnormalities Mouth Dermatologic Agents Ichthyosis Congenita II Hyperkeratosis

来源：评论

学校读者我要写书评

暂无评论

Pilot study of the tolerability and toxicity of intravesical valrubicin immediately after transurethral resection of superficial bladder cancer

引用

UROLOGY 2000年第2期56卷 232-235页

作者： Patterson, AL Greenberg, RE Weems, L Bahnson, R Wajsman, Z Israel, M Sweatman, T Webber, D Gulfo, J Univ Tennessee Coll Med Dept Urol Memphis TN 38104 USA Vet Affairs Med Ctr Memphis TN USA Fox Chase Canc Ctr Philadelphia PA 19111 USA Mississippi Urol Clin Jackson MS USA Univ Pittsburgh Pittsburgh PA USA Univ Florida Med Ctr Gainesville FL USA Anthra Pharmaceut Princeton NJ USA

Objectives. To assess in a pilot study the safety, tolerability, and technical feasibility of administering intravesical valrubicin immediately after transurethral resection of bladder tumors (TURBT) in patients with superficial bladder cancer and to evaluate the optimal dose of valrubicin and its systemic absorption. Methods. Twenty-two patients with recurrent or newly diagnosed Stage Ta or T1 transitional cell tumors received a single dose of 400 mg, 600 mg, or 800 mg of intravesical valrubicin immediately after TURBT, Four patients thought to be at high risk of recurrence were followed up with five additional doses of 800 mg valrubicin, given weekly. Results. The use of valrubicin after TURBT was generally well tolerated, Little evidence was found to suggest a direct relationship among the dose of valrubicin, the time between the end of TURBT and drug instillation, and the occurrence of most bladder symptoms. The most commonly reported adverse events included dysuria (77%), hematuria (59%), and urgency/frequency (23%), Pharmacokinetic analyses revealed that the mean systemic exposure to valrubicin and its metabolites depended on the extent of the TURBT and the damage to the bladder wall. Conclusions. The results of this study indicated that administration of valrubicin immediately after TURBT is feasible. UROLOGY 56: 232-235, 2000. (C) 2000, Elsevier Science Inc.

关键词：投药膀胱内原位癌/药物疗法原位癌/预防和控制原位癌/外科学综合疗法多柔比星/投药和剂量多柔比星/副作用多柔比星/类似物和衍生物多柔比星/治疗应用用药计划表试点项目手术后并发症/诊断手术后并发症/流行病学手术后并发症/病因学挽救疗法治疗结果膀胱/外科学膀胱肿瘤/药物疗法膀胱肿瘤/预防和控制膀胱肿瘤/外科学排尿障碍/诊断排尿障碍/流行病学排尿障碍/病因学老年人人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

PROLONGED COAGULATION INSTABILITY IS ASSOCIATED WITH A HIGHER-DOSE REGIMEN OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION

引用

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1992年第1期667卷 450-453页

作者： ANDREOTTI, F KLUFT, C DAVIES, GJ HACKETT, DR PREVOST, R MASERI, A TNO IVVOGAUBIUS LAB2300 AK LEIDENNETHERLANDS

来源：评论

学校读者我要写书评

暂无评论

An audit of cyclosporin for systemic lupus erythematosus and related overlap syndromes: limitations of its use

引用

ANNALS OF THE RHEUMATIC DISEASES 2000年第6期59卷 487-489页

作者： Morton, SJ Powell, RJ Univ Hosp Queens Med Ctr Clin Immunol Unit Nottingham NG27 2UH England

Objective-To establish the usefulness of cyclosporin for systemic lupus erythematosus (SLE) in a routine clinical setting. Methods-Patients who had received cyclosporin for SLE, mixed connective tissue disease, and other overlap syndromes were identified. Data relating to treatment with cyclosporin, including dosage, concurrent steroid use, response to treatment, side effects, and reasons for withdrawal, were extracted from medical notes. Results-A total of 43 patients had been treated with cyclosporin between 1995 and 1998. Cyclosporin, average dose 4 mg/kg/d, was started in patients whose disease was active despite previous use of alternative second line agents. On every occasion when cyclosporin was used for thrombocytopenia the response was good, but when arthritis was the indication, the response was good in 14/26. The success rates for symptoms of arthralgia, myalgia, and fatigue were lower. Side effects occurred in 28/43 (65%) cases, and on 39/47 (83%) occasions cyclosporin was withdrawn owing to either side effects or failure to control disease activity, after a median duration of treatment of only four months. Conclusions-The response to cyclosporin is mixed and usually short lived.

关键词：环孢菌素/副作用环孢菌素/治疗应用用药计划表高血压/化学诱导免疫抑制剂/副作用免疫抑制剂/治疗应用红斑狼疮系统性/药物疗法回顾性研究成年人女(雌)性人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

Conservative treatment of phimosis in children using a topical steroid

引用

UROLOGY 2000年第2期56卷 307-310页

作者： Orsola, A Caffaratti, J Garat, JM Fdn Puigvert Dept Pediat Urol Barcelona Spain

Objectives. From 1997 through 1998, we conducted a prospective study to evaluate the long-term outcome of using topical steroids in the treatment of childhood phimosis. Methods. Both the parents and their children were instructed to apply 0.05% betamethasone cream topically twice a day for 1 month and to retract the prepuce after the fifth day of treatment, Results were evaluated at the end of the treatment and 6 months later. Results. One hundred thirty-seven boys were evaluated. The median age was 5.4 years. At initial presentation, 61 boys had a phimotic but retractable prepuce, 37 had a nonretractable phimotic ring, and 39 had a pinpoint opening, Patients with a history of previous forcible foreskin retractions were considered to have secondary phimosis. By 6 months following treatment, 90% (124 children) had an easily retractable prepuce without a phimotic ring. No differences were seen in the response rate between those with primary and secondary phimosis. In all cases, the treatment was well tolerated without local or systemic side effects. All the patients with persistent or recurrent phimosis were found to be noncompliant with the suggested daily foreskin care. Conclusions. Topical steroid for the treatment of phimosis is a safe, simple, and inexpensive procedure that avoids surgery and its associated risks. It is effective both in primary and in secondary phimosis. We emphasize the importance of proper and regular foreskin care and hypothesize on the mechanism of action of the steroids. UROLOGY 56: 307-310, 2000. (C) 2000, Elsevier Science Inc.

关键词：投药局部年龄因素消炎药/治疗应用倍他米松/治疗应用用药计划表糖皮质激素类阴茎/生长和发育阴茎/生理学包茎/药物疗法前瞻性研究治疗结果儿童儿童学龄前人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

Lack of efficacy of 24-h infusional topotecan in platinum-refractory ovarian cancer: A gynecologic oncology group trial

引用

GYNECOLOGIC ONCOLOGY 1999年第3期75卷 444-446页

作者： Markman, M Blessing, JA DeGeest, K Morgan, M Look, KY Herzog, TJ Rose, PG Cleveland Clin Fdn Dept Med Hematol Oncol Ctr Canc Cleveland OH 44195 USA Roswell Pk Canc Inst Gynecol Oncol Grp Buffalo NY 14263 USA Rush Med Coll Chicago IL 60612 USA Univ Penn Div Gynecol Oncol Philadelphia PA 19104 USA Indiana Univ Sch Med Gynecol Oncol Sect Dept Obstet & Gynecol Indianapolis IN 46202 USA Washington Univ Sch Med Div Gynecol Oncol Dept Obstet & Gynecol St Louis MO 63110 USA Case Western Reserve Univ Hosp Div Gynecol Oncol Dept Obstet & Gynecol Cleveland OH 44106 USA

Background. The aim of this study was to evaluate the efficacy of a more convenient topotecan administration schedule in the second-line treatment of advanced platinum-refractory ovarian cancer. Methods and materials. The Gynecologic Oncology Group conducted a Phase II trial of 24-h infusional topotecan (8.5 mg/m(2)), repeated every 3 weeks in 26 patients with platinum-refractory ovarian cancer (failure to respond to initial platinum-based treatment or development of recurrent disease within 6 months of completion of chemotherapy). Results. Grade 4 neutropenia (85% of patients) and thrombocytopenia (12%) were the major toxicities encountered. Of the 25 patients evaluable for response, only a single patient experienced an objective response (4%). Conclusions. When employed at this dose and schedule (24-h infusion every 3 weeks), topotecan has minimal second-line activity in platinum-refractory ovarian cancer. (C) 1999 Academic Press.

关键词：抗肿瘤药/治疗应用卡铂/治疗应用顺铂/治疗应用用药计划表抗药性肿瘤卵巢肿瘤/药物疗法托泊替坎/投药和剂量托泊替坎/治疗应用成年人老年人老年人 80以上女(雌)性人类中年人

来源：评论

学校读者我要写书评

暂无评论

Cisplatin and pentoxifylline in advanced or recurrent squamous cell carcinoma of the cervix: A phase II trial of the gynecologic oncology group

引用

GYNECOLOGIC ONCOLOGY 2000年第1期79卷 64-66页

作者： Mannel, RS Blessing, JA Boike, G Univ Oklahoma Hlth Sci Ctr Dept Obstet & Gynecol Oklahoma City OK 73190 USA Roswell Pk Canc Inst Gynecol Oncol Grp Buffalo NY 14263 USA Michigan State Univ Hurley Med Ctr Coll Human Med Flint MI 48503 USA

Objective. The aim of this study was to determine the antitumor activity and toxicity of cisplatin and pentoxifylline in previously treated patients with squamous cell carcinoma of the cervix. Methods. A Gynecologic Oncology Group (GOG) Phase LI trial of recurrent squamous cell cervical cancer using standard GOG response and toxicity criteria was performed. Results. A total of 47 patients with advanced or recurrent squamous tell carcinoma of the cervix were entered. The starting dose was 75 mg/m(2) of cisplatin every 21 days and 1600 mg of pentoxifylline PO every 8 h for nine doses during each course. Forty patients were evaluable for response and 44 were evaluable for toxicity. Of the 40 evaluable patients, 37 had received prior radiotherapy and 35 had received prior chemotherapy. A median of three courses were given (range: 1-7). Among evaluable patients, 1 had a complete response (2.5%) and 3 had a partial response (7.5%) for an overall objective response rate of 10%. The complete responder had not previously had chemotherapy. Grade 3 or 4 toxicity was predominantly nausea and vomiting (32%) and hematologic toxicity (23%). Conclusions. The combination of cisplatin and pentoxifylline at the dose and schedule tested has limited activity in previously treated advanced or recurrent cervical cancer. (C) 2000 Academic Press.

关键词：癌鳞状细胞/药物疗法顺铂/投药和剂量用药计划表肿瘤复发局部/药物疗法肿瘤分期己酮可可碱/投药和剂量宫颈肿瘤/药物疗法女(雌)性人类中年人

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：