作者:
Ghanem, C. I.Mottino, A. D.Univ Nacl Rosario
CONICET Fac Ciencias Bioquim & Farmaceut Inst Fisiol ExptDept Ciencias Fisiol RA-2000 Rosario Argentina Univ Buenos Aires
CONICET Fac Farm & Bioquim Catedra FisiopatolInst Invest FarmacolDept Cien Buenos Aires DF Argentina
The article by JE Rossouw titled "Postmenopausal hormone therapy for disease prevention: have we learned any lessons from the past" describes the history of estrogen therapy proceeding through the stages of ...
详细信息
The article by JE Rossouw titled "Postmenopausal hormone therapy for disease prevention: have we learned any lessons from the past" describes the history of estrogen therapy proceeding through the stages of uncritical adoption, acute concerns about safety and a current more nuanced view of selective timing and duration of *** briefly noted in the article, the warning signs that raised concern about the cardiovascular safety of estrogens were first noticed more than 40 years ago. Laboratory and epidemiological studies describing the occurrence of thrombosis in women on oral contraceptives, and increased nonfatal myocardial infarction and thromboembolism in men receiving conjugated estrogens for the secondary prevention of cardiovascular disease, were reported then. Subsequent numerous evaluations defined the multiple prothrombotic effects of estrogens on the coagulation system and the role of genetic factors in modulating this risk.
We are confused by the article by Tolia and Boyer , and concerned that some of their most important claims were not based on the data presented. Therefore, they may not be *** stated objectives of the study were "...
详细信息
We are confused by the article by Tolia and Boyer , and concerned that some of their most important claims were not based on the data presented. Therefore, they may not be *** stated objectives of the study were "to assess the efficacy of continuous proton pump inhibitor (PPI) therapy in children and to evaluate changes in biochemical, endoscopic and histologic parameters during such treatment", whereas the major goal of the article title is "a retrospective review of safety". It is one particular claim with which we take the most issue-that of the reported absence of enterochromaf-fm-like (ECL) cell hyperplasia in the patients.
Weekly paclitaxel plus Herceptin in metastatic breast cancer patients who relapse after stem-cell transplant J. R. Sporn Search for other works by this author on: Oxford Academic PubMed Google Scholar J. R. Sporn S. A...
详细信息
Weekly paclitaxel plus Herceptin in metastatic breast cancer patients who relapse after stem-cell transplant J. R. Sporn Search for other works by this author on: Oxford Academic PubMed Google Scholar J. R. Sporn S. A. Bilgrami Search for other works by this author on: Oxford Academic PubMed Google Scholar S. A. Bilgrami Annals of Oncology, Volume 10, Issue 10, 1 October 1999, Pages 1259–1260, https://***/10.1023/A:1008302601302 Published: 01 October 1999
暂无评论