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中国校医 2013年第11期27卷 845-847页

作者：许丽明王宏梗福建医科大学附属第二医院麻醉科福建泉州362000

目的观察瑞芬太尼递减停药法对术后痛觉过敏的影响。方法全麻择期腹腔镜下胃癌根治术男性患者40例,ASA分级I^II级,随机分为2组,瑞芬太尼递减停药组(G组)和瑞芬太尼恒速给药组(C组),每组20例;观察2组术后发生痛觉过敏的程度、追加舒芬太... 详细信息

目的观察瑞芬太尼递减停药法对术后痛觉过敏的影响。方法全麻择期腹腔镜下胃癌根治术男性患者40例,ASA分级I^II级,随机分为2组,瑞芬太尼递减停药组(G组)和瑞芬太尼恒速给药组(C组),每组20例;观察2组术后发生痛觉过敏的程度、追加舒芬太尼的剂量,对患者自主呼吸、意识恢复和拔管时间的影响,以及不良反应如呼吸抑制的发生率。结果 2组拔管时间差异无统计学意义(P>0.05),2组术后VAS评分差异有统计学意义(P<0.05)。结论瑞芬太尼递减停药法可减少术后痛觉过敏的发生。

关键词：瑞芬太尼痛觉过敏用药计划表

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The efficacy and safety of intramuscularly administered 15(S) 15 methyl prostaglandin E₂ methyl ester for induction of artificial abortion

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American Journal of Obstetrics and Gynecology 1975年第1期123卷 19-31页

作者： Brenner, W.E. Dingfelder, J.R. Staurovsky, L.G. United States

The practicability of an intramuscular dose schedule of 10 μg of 15(S) 15 methyl prostaglandin E2 methyl ester [15(S) Me PGE2] administered every 4 hours was evaluated in 42 subjects from 7 to 20 menstrual weeks'... 详细信息

The practicability of an intramuscular dose schedule of 10 μg of 15(S) 15 methyl prostaglandin E₂ methyl ester [15(S) Me PGE₂] administered every 4 hours was evaluated in 42 subjects from 7 to 20 menstrual weeks' gestation. Half of the subjects served as controls (Group I) and half of the subjects (Group II) were treated with a medication regimen of prochlorperazine, acetylsalicylic acid, diphenoxylate hydrochloride, and atropine sulfate to evaluate the regimen's effects. Although the 15(S) Me PGE₂ dose schedule appeared to be effective (74% aborted in 24 hours and 95% aborted within 48 hours in a mean time of 18.9 hours), Group I (control) subjects frequently had side effects: 62% had emesis, 86% had diarrhea, 76% had shivering, and 76% had fever (>100°F.). Fewer Group II (medicated) subjects had side effects: 43% had emesis, 19% had diarrhea, 52% had shivering, and 43% had fever. The medication regimen did not appear to interfere with the abortifacient or oxytocic effects of the 15(S) Me PGE₂ dose schedule, since Group I and Group II subjects had similar cumulative abortion rates, mean abortion times, and uterine activity. Although this 15(S) Me PGE₂ dose schedule is effective in first trimester patients, it is probably less satisfactory than the conventional method of vacuum aspiration. While intramuscularly administered 15(S) Me PGE₂ with medications to attenuate side effects may be practicable for inducing midtrimester abortion, especially between 12 and 16 weeks' gestation, large controlled comparative studies of the intramuscular 15(S) Me PGE₂ method and other experimental and conventional methods will be necessary to determine the most satisfactory method of performing midtrimester abortions.

关键词：流产人工阿司匹林/药理学阿托品/药理学腹泻/化学诱导地芬诺酯/药理学用药计划表药物评价发热/化学诱导孕龄注射肌肉内妊娠初期妊娠中期丙氯拉嗪/药理学前列腺素E类/投药和剂量前列腺素E类/副作用寒战呕吐/化学诱导青少年成年人女(雌)性人类妊娠

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老幼用药剂量折算新方法─—直角坐标检索法

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中国现代应用药学 1995年第3期12卷 54-55页

作者：王祝彬解放军第一五七医院

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A differential assessment of the cumulative versus stabilizing effect of methadone maintenance treatment

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EVALUATION REVIEW 1998年第2期22卷 175-206页

作者： Powers, KI Anglin, MD Univ Calif Los Angeles Drug Abuse Res Ctr Los Angeles CA 90024 USA Univ Calif Los Angeles Dept Behav Sci Los Angeles CA 90024 USA

Differential response effectiveness is examined for patients during multiple episodes of methadone maintenance (MM) treatment. Subjects were 251 narcotics addicts who were divided into three groups based on their daily narcotics use pattern during their first two MM treatment periods: (1) a "stabilizing group"-showing no daily use for both periods, (2) a "cumulative group"-showing a lower level of daily use during the second period compared to the first, and (3) a "deteriorating group"-showing higher daily use during the second period. Behavioral measures for various narcotics-related variables were plotted over 4 time periods (pre-MM, during first MM, between first and second episodes, and during second MM) were compared. Results indicated several individual differences related to patients' response to multiple episodes of MM. Clinical, research, and policy implications are discussed.

关键词：加利福尼亚卡方分布判别分析剂量效应关系药物用药计划表纵向研究美沙酮/投药和剂量麻醉品/投药和剂量政策制订预后方案评价/方法回顾性研究物质相关性障碍/康复治疗结果青少年成年人女(雌)性人类男(雄)性

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抗菌药物用药时间间隔统计分析

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中国全科医学 2007年第10期10卷 819-820页

作者：周长明袁晓勤李新平杭州市武警浙江总队医院浙江省杭州市310051

目的了解抗菌药物用药时间间隔现状及其合理性。方法以某医院住院患者3d内的在线电子病历作为研究对象,统计不同抗菌药物使用不同时间间隔情况。结果临床上抗菌药物使用按1～2次/d给药的比例较大,与说明书标明的用药时间间隔有明显差异... 详细信息

目的了解抗菌药物用药时间间隔现状及其合理性。方法以某医院住院患者3d内的在线电子病历作为研究对象,统计不同抗菌药物使用不同时间间隔情况。结果临床上抗菌药物使用按1～2次/d给药的比例较大,与说明书标明的用药时间间隔有明显差异。结论由于抗生素的后效应,1～2次/d给药时间间隔具有一定的合理性,但要根据具体情况采取合理方案,以达到满意的治疗效果。

关键词：抗菌药用药计划表

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The potential of combined modality approaches for the treatment of malignant bone tumors in children

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Cancer Treatment Reviews 1975年第1期2卷 33-42,IN1,43-53页

作者： Jaffe, Norman Sidney Farber Cancer Center Boston MA United States

A coordinated multidisciplinary approach is improving the potential for survival in the malignant bone tumors in childhood. Treatment is designed to ablate the primary tumor and eradicate clinical micrometastases which are present in the majority of tumors at the time of diagnosis. Surgery and radiation therapy represent the major forms of primary treatment. This is followed by adjuvant systemic chemotherapy. The tumoricidal potential of radiation therapy may be augmented by chemotherapy. Additional investigations are required to characterize the role of immunotherapy and its relationship to chemotherapy in adjuvant treatment. © 1975 Academic Press.

关键词：骨肿瘤/药物疗法骨肿瘤/死亡率骨肿瘤/治疗用药计划表药物协同作用药物疗法联合免疫疗法/方法肺肿瘤/诊断显像甲氨蝶呤/治疗应用肿瘤转移骨肉瘤/治疗放射摄影术肉瘤 Ewing/治疗青少年成年人儿童儿童学龄前人类婴儿

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针对疗养院的特点做好药品供应工作

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药学与临床研究 1999年第2期14卷 50-51页

作者：兰青青江苏省钟山干部疗养院南京210014

一所疗养院的医疗质量如何,不仅取决于医疗技术、护理水平,而且很大程度上取决于合理用药水平。对于不同规模、不同特色的疗养院来说,根据自身的特点来确定本院用药是十分重要的。由于疗养院与综合性的医院性质不同,多以健康疗养、康复... 详细信息

一所疗养院的医疗质量如何,不仅取决于医疗技术、护理水平,而且很大程度上取决于合理用药水平。对于不同规模、不同特色的疗养院来说,根据自身的特点来确定本院用药是十分重要的。由于疗养院与综合性的医院性质不同,多以健康疗养、康复性疗养为多,有时也收治一些慢性病人。

关键词：疗养院药品供应疗养员药剂科医疗质量用药计划表健康疗养抗心律失常药心血管疾病指导思想

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Tranquilizers, stimulants, and enhancers of cognition

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Physical Medicine and Rehabilitation Clinics of North America 1999年第2期10卷 463-472页

作者： Flitman, S.S. Phoenix AZ 85013 500 West Thomas United States

For patients with cognitive dysfunction, the appropriate use of neurotransmitter specific medication may permit independent living. This article examines a variety of tranquilizers, stimulants, and enhancers of cognit... 详细信息

关键词：抗焦虑药/治疗应用抗精神病药/治疗应用中枢神经系统刺激剂/治疗应用认知障碍/药物疗法剂量效应关系药物用药计划表催眠药和镇静药/治疗应用安定药/治疗应用治疗结果女(雌)性人类男(雄)性

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The cell cycle and its significance for cancer treatment

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Cancer Treatment Reviews 1975年第3期2卷 159-175页

作者： Hill, Bridget T. Baserga, Renato United Kingdom Temple University Medical School Health Sciences Center Philadelphia Pa United States

The evidence presented above shows clearly that the application of certain principles of cell cycle kinetics can be of great benefit in the design of cancer treatments. The clinical advantages produced by using this approach are:o(i)a reduction in the toxicity of single drug therapy,(ii)a reduction in the toxicity of combination schedules without loss of therapeuticeffect, and(iii)a rational basis for the selection of agents for future combination therapy trials. Future advances which would be of great importance clinically would be the development of a clonogenic stem cell assay for human solid tumors and the introduction of techniques for partial tumour cell synchrony in vivo. © 1975 Academic Press.

关键词：抗肿瘤药/投药和剂量抗肿瘤药/药理学抗肿瘤药/治疗应用细胞分裂/药物作用疾病模型动物用药计划表药物协同作用药物疗法联合动力学肿瘤/药物疗法肿瘤/病理学肿瘤/治疗动物人类

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Randomized comparison of enoxaparin with unfractionated heparin for the prevention of venous thromboembolism in medical patients with heart failure or severe respiratory disease

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American Heart Journal 2003年第4期145卷 614-621页

作者： Kleber, Franz-Xaver Witt, Christian Vogel, Günter Koppenhagen, Klaus Schomaker, Ulrike Flosbach, Curt Werner Unfallkrankenhaus Berlin Germany Univ. Klin. Charité Humboldt-Universität Berlin Germany Klinikum Erfurt Erfurt Germany Klinikum Steglitz Freie Universität Berlin Germany Cologne Ortweinstrasse 2 Germany Rhône-Poulenc Rorer Aventis Pharma Cologne Germany Department Internal Medicine Unfallkrankenhaus Berlin Akademisches Lehrkrankenhaus F. D-12683 Berlin Warenerstr. 7 Germany

Background: We compared the efficacy and safety of the low-molecular weight heparin enoxaparin with unfractionated heparin (UFH) for the prevention of venous thromboembolic disease in patients with heart failure or severe respiratory disease. Methods: This was a multicenter, controlled, randomized, open study in which patients received either enoxaparin (40 mg once daily) or UFH (5000 IU 3 times daily) for 10 ± 2 days in 64 medical departments in Germany. Patients were stratified and enrolled according to their underlying disease: severe respiratory disease or heart failure. The primary efficacy parameter was a thromboembolic event up to 1 day after the treatment period. Results: Of the 665 patients enrolled, 451 patients were able to be evaluated in the primary efficacy analysis. The incidence of thromboembolic events was 8.4% with enoxaparin and 10.4% with UFH. Enoxaparin was at least as effective as UFH, with a 1-sided equivalence region of -4% (90% CI -2.5-6.5, P = .015). Enoxaparin was associated with fewer deaths, less bleeding, and significantly fewer adverse events (45.8% vs 53.8%, P = .044). Conclusions: Enoxaparin is at least as effective as UFH in the prevention of thromboembolic events in patients with heart failure or severe respiratory disease. Its beneficial safety profile and once-daily administration is advantageous for inpatient and outpatient use.

关键词：抗凝药/投药和剂量抗凝药/治疗应用用药计划表依诺肝素/投药和剂量依诺肝素/治疗应用出血/化学诱导肝素/投药和剂量肝素/治疗应用呼吸道疾病/并发症血栓栓塞/并发症血栓栓塞/预防和控制静脉血栓形成/并发症静脉血栓形成/预防和控制老年人女(雌)性人类男(雄)性中年人

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