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Effect of estrogen on exercise electrocardiograms in healthy postmenopausal women

AMERICAN JOURNAL OF CARDIOLOGY 2000年第4期86卷 477-+页

作者： Rovang, KS Arouni, AJ Mohiuddin, SM Tejani, A Hilleman, DE Creighton Univ Cardiac Ctr Omaha NE 68178 USA

We pospectively evaluated the effect of estrogen on the ST-segment response during exercise stress testing in 47 postmenopausal women. Our study observed that approximately 1 in 5 postmenopausal women will have a fals... 详细信息

关键词：投药口服用药计划表超声心动描记术心电描记术/药物作用雌激素类共扼(USP)/投药和剂量雌激素类共扼(USP)/药理学运动试验假阳性反应甲羟孕酮/投药和剂量甲羟孕酮/药理学绝经后期/生理学孕酮同源物/投药和剂量孕酮同源物/药理学老年人女(雌)性人类中年人

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Chemotherapy in cervical cancer: Is cisplatin alone still the standard of care?

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ANNALS OF ONCOLOGY 2001年第7期12卷 883-883页

作者： Tattersall, MHN Univ Sydney Dept Canc Med Sydney NSW 2006 Australia

Chemotherapy in cervical cancer: Is cisplatin alone still the standard of care? M. H. N. Tattersall Search for other works by this author on: Oxford Academic PubMed Google Scholar M. H. N. Tattersall Annals of Oncolog... 详细信息

关键词：抗肿瘤药/投药和剂量抗肿瘤药/治疗应用抗肿瘤联合化疗方案/治疗应用顺铂/投药和剂量顺铂/治疗应用用药计划表诊疗准则(主题) 宫颈肿瘤/药物疗法宫颈肿瘤/放射疗法女(雌)性人类

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Alternate-day dosing of aspirin in atrial fibrillation: A critical evaluation

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AMERICAN HEART JOURNAL 1999年第1期138卷 13-13页

作者： Howes, CJ Ezekowitz, MD Yale Univ Sch Med Sect Cardiovasc Med New Haven CT 06520 USA

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Oral misoprostol and intracervical dinoprostone for cervical ripening and labor induction: A randomized comparison

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OBSTETRICS AND GYNECOLOGY 2000年第3期96卷 465-469页

作者： Bartha, JL Comino-Delgado, R Garcia-Benasach, F Martinez-Del-Fresno, P Moreno-Corral, LJ Hosp Univ Puerto Real Dept Obstet & Gynecol Cadiz Spain

Objective: To compare efficacy, safety, and tolerance of oral misoprostol with intracervical dinoprostone for cervical ripening and labor induction. Methods: Two hundred women were randomized to receive single doses of oral misoprostol 200 mu g or 0.5 mg of dinoprostone intracervically every 6 hours for a maximum four doses. Results: The intervals from administration of the drug to active phase of labor (11.1 hours [7-24] versus 15.8 hours [7.5-29.62], P = .01), to delivery (14.0 hours [8.42-27.61] versus 20.2 hours [16.7-32.8], P = .01), and to rupture of membranes (10.0 hours [4.95-24.7] versus 15.6 hours [8.2-29.2], P = .003) were significantly shorter in the misoprostol group. All those variables were not distributed normally, so results are presented as median and interquartile range. The rates of women who needed oxytocin (68% versus 52%, P = .03) and cesarean for failed induction (9% versus 1%, P = .01) were higher in the dinoprostone group. Conclusion: A single dose of 200 mu g oral misoprostol was more effective for cervical ripening and labor induction than 0.5 mg of dinoprostone intracervically every 6 hours, with a maximum of four doses. (Obstet Gynecol 2000;96:465-9. (C) 2000 by The American College of Obstetricians and Gynecologists.).

关键词：投药阴道内投药口服子宫颈/药物作用地诺前列酮/投药和剂量地诺前列酮/副作用剂量效应关系药物用药计划表引产米索前列醇/投药和剂量米索前列醇/副作用催产药/投药和剂量催产药/副作用治疗结果成年人女(雌)性人类婴儿新生妊娠

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Changes in serum chitotriosidase activity with cessation of replacement enzyme (cerebrosidase) administration in Gaucher disease

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CLINICAL BIOCHEMISTRY 2000年第2期33卷 147-149页

作者： Czartoryska, B Tylki-Szymanska, A Lugowska, A Inst Psychiat & Neurol Dept Genet PL-02957 Warsaw Poland Childrens Mem Hlth Inst Dept Metab Dis Warsaw Poland

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Melatonin for the treatment of handicapped children with severe sleep disorders

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PEDIATRIC NEUROLOGY 2000年第3期23卷 229-232页

作者： Jan, MMS King Abdulaziz Univ Hosp Dept Pediat Div Neurol Jeddah 21452 Saudi Arabia Coll Med & Allied Hlth Sci Jeddah Saudi Arabia

Sleep disorders are common in children with mental retardation and neurologic disorders. Melatonin, a recently developed natural compound, has been used successfully in sleep disorders. I report my experience with melatonin in an open, prospective trial to treat circadian rhythm sleep disorder in handicapped children. The sleep disorder had been present for at least 6 months and had not responded to at least one hypnotic drug. The therapeutic response was recorded according to the average number of hours asleep per 24 hours, average number of awakening per night, average number of nights with delayed sleep onset, and average number of nights with early morning arousals. Ten consecutive children (four males, six females;age range = 1-11 years, mean 5.4) were included. Nine children had documented mental retardation that was severe in six (67%). Most had epilepsy and visual impairment (70%). All children were monitored for 4-12 months (mean 7.5 months) after the initiation of 3-mg bedtime melatonin. Most (80%) had a dramatic response to melatonin. No side effects were reported. Melatonin is a well-tolerated, safe, relatively inexpensive, and effective drug, with minimal side effects, for the treatment of severe circadian rhythm sleep disorder in handicapped children. Wider use of this drug is recommended. (C) 2000 by Elsevier Science Inc. All rights reserved.

关键词：昼夜节律/药物作用残疾儿童用药计划表褪黑激素/投药和剂量精神发育迟滞/药物疗法精神发育迟滞/病因学前瞻性研究睡眠障碍昼夜节律性/药物疗法睡眠障碍昼夜节律性/病因学觉醒状态/药物作用儿童儿童学龄前女(雌)性人类婴儿男(雄)性

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Weekly carboplatin as a strategy to prevent severe treatment-related emesis

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GYNECOLOGIC ONCOLOGY 2000年第2期78卷 265-265页

作者： Markman, M Kulp, B Peterson, G Kennedy, A Cleveland Clin Taussig Canc Ctr Cleveland OH 44195 USA

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Scleromyxedema: Response to high-dose intravenous immunoglobulin (hdIVIg)

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JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2000年第2期43卷 403-408页

作者： Lister, RK Jolles, S Whittaker, S Black, C Forgacs, I Cramp, M Potter, M Rustin, MHA Royal Free Hosp Dept Dermatol London NW3 2QG England Royal Free Hosp Dept Rheumatol London NW3 2QG England Royal Free Hosp Dept Haematol London NW3 2QG England Natl Inst Med Res Div Cellular Immunol London NW7 1AA England Univ London Kings Coll Dept Med London WC2R 2LS England

We report 2 patients with scleromyxedema, both associated with IgG-lambda paraproteinemia, who were treated with high-dose intravenous immunoglobulin (hdIVIg) 2 g/kg per month. The response to treatment was assessed using an objective skin scoring system initially established for patients with scleroderma. This system grades the overall severity of the induration and the reduction in mobility of the skin. Both patients initially had a dramatic response to treatment which was sustained in one patient. The first patient, a 30-year-old black man, showed a reduction in skin scores from 36/60 to 11/60 over a 3-month period, during which time he had 3 infusions of hdIVIg. After an unplanned 2-month break from treatment, severe neuromuscular complications developed. These improved initially with more frequent infusions of hdIVIg but oral corticosteroids were required to treat worsening myopathy. Unfortunately the initial response to hdIVIg has not been sustained and his skin scores at 1 year returned to baseline. The second patient, a 60-year-old white man, showed a similarly dramatic reduction in skin scores from 36/60 to 15/60 over a 3-month period after having received only 2 infusions of hdIVIg. There has been sustained improvement after 10 months of therapy and the interval between hdIVIg infusions has been increased to 10 weeks without deterioration. HdIVIg may be an effective treatment for some patients with scleromyxedema, a rare condition with few effective treatments and a poor prognosis.

关键词：剂量效应关系药物用药计划表免疫法被动免疫球蛋白λ链/血液硬化萎缩苔癣/诊断硬化萎缩苔癣/免疫学硬化萎缩苔癣/病理学硬化萎缩苔癣/治疗副蛋白血症/诊断副蛋白血症/免疫学副蛋白血症/病理学副蛋白血症/治疗硬皮病局部性/诊断硬皮病局部性/免疫学硬皮病局部性/病理学硬皮病局部性/治疗皮肤/病理学治疗结果成年人人类男(雄)性中年人

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PLASMA HEPARIN CONCENTRATIONS DURING SUBCUTANEOUS HEPARIN THERAPY

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AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE 1976年第5期6卷 454-458页

作者： PITNEY, WR DEAN, S UNIV NEW S WALES ST GEORGE HOSP SCH MED MED PROFESSIONAL UNIT KOGARAH 2217 NEW S WALES AUSTRALIA

Plasma heparin concentrations were measured at 2 h intervals following the s.c. injection of varying doses of heparin to patients with venous thrombosis. With doses of 5000 and 10,000 units peak plasma concentrations were seen most commonly 4 h after the injection. There was a wide range of peak values at both dose levels with considerable overlap and no correlation could be shown between plasma heparin concentration and the age, sex or weight of the individual. Only traces of heparin could be detected in the blood after a 1000 unit injection. Comparable results were obtained up to 6 h after the injection with either the Ca or Na salts of heparin.

关键词：用药计划表肝素/投药和剂量肝素/血液注射皮下心肌梗死/血液血栓性静脉炎/血液成年人老年人女(雌)性人类男(雄)性中年人

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Depomedroxyprogesterone-induced hypoestrogenism and changes in vaginal flora and epithelium

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OBSTETRICS AND GYNECOLOGY 2000年第3期96卷 431-439页

作者： Miller, L Patton, DT Meier, A Thwin, SS Hooton, TM Eschenbach, DA Univ Washington Dept Obstet & Gynecol Div Infect Dis Seattle WA 98195 USA Univ Washington Dept Med Div Infect Dis Seattle WA 98195 USA

Objective: To identify the effects of depomedroxyprogesterone acetate (DMPA) on vaginal microbial flora and epithelium. Methods: Women who desired DMPA for contraception were evaluated before and at 3 and 6 months after initiation of 150-mg DMPA injections every 3 months. At each visit, we assessed genital symptoms, vaginal signs, vaginal microflora, and histopathology by vaginal biopsies. Results: Among 38 women observed for 6 months, there was significant reduction in mean serum estradiol level (99.9 +/- 9.3 pg/mL to 26.6 +/- 1.6 pg/mL, P < .001). The number of subjects with any Lactobacillus did not change, but the number with hydrogen peroxide (H2O2)-positive Lactobacillus decreased from 20% before to 12% after 6 months of DMPA (P = .005). The log concentration in colony-forming units per milliliter of vaginal fluid of H2O2-positive Lactobacillus decreased in a linear manner from 4.0 +/- 0.6 at baseline to 2.5 +/- 0.6 after 6 months of DMPA use (P = .006). The mean number of cell layers in the epithelium was reduced slightly from 28.1 +/- 0.7 to 25.9 +/- 0.9 (P = .05), epithelial thickness decreased from 1.02 +/- 0.04 mm to 0.89 +/- 0.05 mm (P = .005), and the glycogen-positive thickness decreased from 0.81 +/- 0.04 mm at baseline to 0.66 +/- 0.05 after 6 months of DMPA use (P = .005). Conclusion: Depomedroxyprogesterone acetate produced a systemic hypoestrogenic state associated with decreased H2O2-positive Lactobacillus colonization and slight thinning of the glycogen vaginal epithelial layer. Such changes possibly compromise the vaginal barrier to infection. (Obstet Gynecol 2000;96:431-9. (C) 2000 by The American College of Obstetricians and Gynecologists.).

关键词：集落计数微生物避孕药女用/投药和剂量避孕药女用/副作用用药计划表上皮/药物作用上皮/微生物学上皮/病理学雌激素类/缺乏随访研究注射肌肉内乳杆菌属/药物作用醋酸甲羟孕酮/投药和剂量醋酸甲羟孕酮/副作用阴道/药物作用阴道/微生物学阴道/病理学青少年成年人女(雌)性人类

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