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中华眼底病杂志 2015年第1期31卷 97-100页

作者：包娅利朱丹陶勇内蒙古医科大学附属医院眼科呼和浩特010050 北京大学人民医院眼科教育部视觉损伤与修复重点实验室

抗病毒药物的玻璃体腔注射能够很快在局部达到有效药物浓度,减少药物对全身其他脏器的非特异性损伤,从而高效治疗病毒性视网膜疾病.急性视网膜坏死综合征、进行性外层视网膜坏死、巨细胞病毒性视网膜炎等疾病应用玻璃体腔注射抗病毒药... 详细信息

抗病毒药物的玻璃体腔注射能够很快在局部达到有效药物浓度,减少药物对全身其他脏器的非特异性损伤,从而高效治疗病毒性视网膜疾病.急性视网膜坏死综合征、进行性外层视网膜坏死、巨细胞病毒性视网膜炎等疾病应用玻璃体腔注射抗病毒药物治疗可取得较好的临床效果.玻璃体腔注射抗病毒药物可以作为病毒性视网膜疾病治疗的一个重要手段而在其治疗过程中首先使用.如何根据药物特性减少其注射频率、降低药物以及注射相关的并发症,提高其对病毒性视网膜疾病的治愈率,仍是值得进一步研究的问题.

关键词：病毒性疾病/药物疗法视网膜疾病/药物疗法抗病毒药/治疗应用综述

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Stealth virus epidemic in the Mohave Valley: Severe vacuolating encephalopathy in a child presenting with a behavioral disorder

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EXPERIMENTAL AND MOLECULAR PATHOLOGY 1999年第1期66卷 19-30页

作者： Martin, WJ Anderson, D Ctr Complex Infect Dis Rosemead CA 91770 USA

An infectious illness, attributed to atypically structured cytopathic "stealth" viruses, occurred in 1996 in the Mohave Valley region of the United States. A stealth virus-infected child from this region has developed a severe noninflammatory, vacuolating (spongiform) encephalopathy. The illness initially presented as a behavioral problem without overt neurological signs. Extensive investigations, including repeated magnetic resonance imaging, two brain biopsies, and stealth virus cultures, have helped define the disease process occurring in this child. Significant clinical benefit with apparent retardation of disease progression occurred during a 6-week course of ganciclovir therapy. The potential contributing role of stealth virus infections in children presenting with behavioral problems needs to be addressed. (C) 1999 Academic Press.

关键词：抗病毒药/治疗应用脑/病理学脑/超微结构加利福尼亚/流行病学更昔洛韦/治疗应用磁共振成像精神障碍/病因学精神障碍/病毒学朊病毒病/药物疗法朊病毒病/流行病学朊病毒病/心理学朊病毒病/病毒学回顾性研究空泡/病理学空泡/超微结构病毒性疾病/诊断病毒性疾病/药物疗法病毒性疾病/流行病学病毒性疾病/心理学儿童人类男(雄)性

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Antiviral agents from plants and herbs: a systematic review

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ANTIVIRAL THERAPY 2003年第2期8卷 77-90页

作者： Martin, KW Ernst, E Univ Exeter Peninsula Med Sch Exeter Devon England Univ Plymouth Exeter Devon England

Background and aims: Many antiviral compounds presently in clinical use have a narrow spectrum of activity, limited therapeutic usefulness and variable toxicity. There is also an emerging problem of resistant viral strains. This study was undertaken to examine the published literature on herbs and plants with antiviral activity, their laboratory evaluation in vitro and in vivo, and evidence of human clinical efficacy. Methods: Independent literature searches were performed on MEDLINE, EMBASE, CISCOM, AMED and Cochrane Library for information on plants and herbs with antiviral activity. There was no restriction on the language of publication. Data from clinical trials of single herb preparations used to treat uncomplicated viral infections were extracted in a standardized, predefined manner. Results: Many hundreds of herbal preparations with antiviral activity were identified and the results of one search presented as an example. Yet extracts from only 11 species met the inclusion criteria of this review and have been tested in clinical trials. They have been used in a total of 33 randomized, and a further eight nonrandomized, clinical trials. Fourteen of these trials described the use of Phyllanthus spp. for treatment of hepatitis B, seven reporting positive and seven reporting negative results. The other 10 herbal medicines had each been tested in between one and nine clinical trials. Only four of these 26 trials reported no benefit from the herbal product. Conclusions: Though most of the clinical trials located reported some benefits from use of antiviral herbal medicines, negative trials may not be published at all. There remains a need for larger, stringently designed, randomized clinical trials to provide conclusive evidence of their efficacy.

关键词：抗病毒药/分离和提纯抗病毒药/治疗应用临床试验(主题) HIV感染/药物疗法乙型肝炎/药物疗法叶下珠属/化学植物药疗法植物提取物/治疗应用植物药用/化学病毒性疾病/药物疗法动物人类

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Antiviral agents for non-human immunodeficiency virus infections

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MAYO CLINIC PROCEEDINGS 1999年第12期74卷 1266-1283页

作者： Keating, MR Mayo Clin & Mayo Fdn Div Infect Dis & Internal Med Rochester MN 55905 USA

Several new agents for treating viral infections have been developed in recent years, All available agents are virustatic, inhibiting specific steps in the process of viral replication. No agent is active against nonreplicating or latent viruses, Acyclovir is useful in the treatment of genital herpes, herpes simplex encephalitis, mucocutaneous herpetic infection, varicella infection in the immunosuppressed host, and herpes tester infection in the normal and the immunosuppressed host. It can also be used for prevention of herpesvirus infection in immunocompromised patients, Ganciclovir is indicated for the treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome and is effective in the treatment and prevention of cytomegalovirus infection in other immunocompromised patients. Famciclovir and valacyclovir are effective in the management of herpes simplex and varicella-zoster infection, Amantadine and rimantadine are useful therapeutically and prophylactically in the management of influenza A virus infection, Chronic hepatitis B infection can respond to lamivudine therapy, and the optimal treatment of hepatitis C is the combination of interferon alfa and ribavirin, Despite pronounced toxic effects, foscarnet and cidofovir are effective antiviral agents in specific settings.

关键词：抗病毒药/药理学抗药性微生物药物临床试用胍类奥司他韦吡喃类病毒性疾病/药物疗法扎那米韦人类

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环磷酰苷治疗病毒性心肌炎疗效观察

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中国误诊学杂志 2008年第33期8卷 8119-8120页

作者：马欣河南省焦作市第二人民医院心内科 454000

目的:观察环磷酰苷治疗病毒性心肌炎的临床疗效。方法:对2006/2008年在我院住院治疗的65例病毒性心肌炎患者随机分为治疗组和对照组,在常规治疗基础上应用环磷腺苷治疗病毒性心肌炎。结果:治疗组加用环磷腺苷明显提高治疗有效率,降低心... 详细信息

目的:观察环磷酰苷治疗病毒性心肌炎的临床疗效。方法:对2006/2008年在我院住院治疗的65例病毒性心肌炎患者随机分为治疗组和对照组,在常规治疗基础上应用环磷腺苷治疗病毒性心肌炎。结果:治疗组加用环磷腺苷明显提高治疗有效率,降低心肌酶,改善临床症状及体征。结论:环磷酰苷治疗病毒性心肌炎有较好的疗效,且无毒副作用。

关键词：环AMP/治疗应用心肌炎/药物疗法病毒性疾病/药物疗法治疗结果人类

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三氮唑核苷治疗小儿急性病毒性上呼吸道感染的临床疗效观察

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中华儿科杂志 1981年第3期19卷 138-139页

作者：张家健王之樑王秀芳赵素兰张淑芳李桂荣胡勇沈芳邓淑琼王继军中国医学科学院儿科研究所北京市海淀医院儿科

我们于1978年春、冬和1979年春,试用我国合成的抗病毒新药——三氮唑核苷治疗小儿急性上呼吸道感染80例,并与未用该药的59例作对照,进行疗效观察,现小结如下。

关键词：病毒性疾病/药物疗法呼吸道感染/药物疗法急性病利巴韦林/治疗应用儿童人类

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抗病毒联合黄芪注射液治疗小儿病毒性心肌炎临床观察

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中国误诊学杂志 2011年第16期11卷 3890-3891页

作者：李慧民河南省扶沟县人民医院儿科 461300

目的探讨常规治疗基础上加用黄芪注射液治疗小儿病毒性心肌炎(VMC)的疗效。方法随机将64例VMC患儿分为对照组和观察组各32例,对照组给予常规治疗,观察组在对照组基础上加用黄芪注射液,观察两组治疗后临床疗效、心电图、心肌酶变化及药... 详细信息

目的探讨常规治疗基础上加用黄芪注射液治疗小儿病毒性心肌炎(VMC)的疗效。方法随机将64例VMC患儿分为对照组和观察组各32例,对照组给予常规治疗,观察组在对照组基础上加用黄芪注射液,观察两组治疗后临床疗效、心电图、心肌酶变化及药物不良反应情况。结果两组总有效率分别为90.63%和65.63%,观察组明显优于对照组(P<0.05),且心电图改善也显著优于对照组(P<0.05);观察组心肌酶改善程度较对照组显著(P<0.05)。两组治疗期间均未发生明显不良反应。结论在常规治疗基础上加用黄芪注射液治疗小儿病毒性心肌炎疗效显著,患儿不良反应少,值得基层医院推广应用。

关键词：抗病毒药/治疗应用黄芪/治疗应用病毒性疾病/药物疗法心肌炎/药物疗法

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1,6-二磷酸果糖治疗病毒性心肌炎疗效观察

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中国误诊学杂志 2009年第10期9卷 2321-2322页

作者：刘俊梅内蒙古武川县医院 011700

目的:探讨1,6-二磷酸果糖治疗病毒性心肌炎的疗效。方法:124例病毒性心肌炎分两组治疗,对照组给以休息,维生素C,能量合剂和抗病毒治疗;治疗组加用16-二磷酸果糖治疗。结果:两组对病毒性心肌炎治疗均有效,但治疗组疗效明显高于对照组。结... 详细信息

目的:探讨1,6-二磷酸果糖治疗病毒性心肌炎的疗效。方法:124例病毒性心肌炎分两组治疗,对照组给以休息,维生素C,能量合剂和抗病毒治疗;治疗组加用16-二磷酸果糖治疗。结果:两组对病毒性心肌炎治疗均有效,但治疗组疗效明显高于对照组。结论:1,6-二磷酸果糖治疗病毒性心肌炎疗效好。

关键词：病毒性疾病/药物疗法心肌炎/药物疗法果糖二磷酸盐类/治疗应用人类

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Laboratory markers of antiviral activity

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ANTIVIRAL THERAPY 1998年第4期3卷 247-250页

作者： Christopherson, C Lu, SD Kwok, S Roche Mol Syst Alameda CA 94501 USA

Quantitative assays for viral nucleic acids have been instrumental in monitoring the response of patients to various antiviral therapies. The level of viraemia is predictive of clinical outcome in that a reduced risk of progression to AIDS or death was observed with lower plasma human immunodeficiency virus (HIV) RNA levels. Rebound in viral levels often signals therapeutic failures, some of which are associated with the development of drug resistance. Quantitative plasma assays for HIV, hepatitis C virus (HCV), cytomegalovirus (CMV) and hepatitis B virus (HBV) have been developed. Over time, modifications to these assays have been required to meet new demands. For example, as antiviral therapies have become more effective, HIV and HCV assays of greater sensitivity are required in order to follow patients for longer periods of time and to fully assess the extent of viral suppression. For HIV-1, a large percentage of patients treated with combination therapies had viral loads that were below the detection limit of the ultrasensitive assay (50 copies/ml). To assess the residual viral burden in this patient population an assay to quantify HIV-1 proviral DNA in peripheral blood mononuclear cells was developed. Studies to date indicate that proviral DNA remains easily detectable despite undetectable plasma RNA and may be useful in monitoring this patient population. To increase assay throughput, a new generation of quantitative assays that will provide real-time detection and a 6 log(10) detection range from a single amplification is under development.

关键词：抗病毒药/治疗应用生物学标记 DNA 病毒/分析指导DNA的DNA聚合酶/代谢抗药性 HIV/分类原病毒/遗传学病毒性疾病/药物疗法病毒性疾病/病毒学人类

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Viral infections of the gastrointestinal tract.

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Current gastroenterology reports 1999年第4期1卷 292-300页

作者： Goodgame, R.W. Department of Gastroenterology Baylor College of Medicine 1 Baylor Plaza Houston 77030-3411 TX United States

Acute gastroenteritis is common in adults. It can occur in institutional epidemics or epidemics of food-borne illness;in these cases, caliciviruses are the major cause of the condition. When acute gastroenteritis occurs in nonepidemic form, its causes are less clear. It may be due to caliciviruses or to the less common serotypes of childhood gastroenteritis viruses, such as rotavirus, astrovirus, and adenovirus. The pathogenesis of acute viral gastroenteritis is not completely understood. Old evidence suggests that mild villus damage is responsible, but new evidence indicates that active secretion and motility disturbance may be involved in the production of symptoms. Five common viruses can remain latent in gastrointestinal tissues and produce disease many years after initial infection. Two major herpesviruses, cytomegalovirus and herpes simplex virus, cause ulcerative disease of the gastrointestinal tract. This disease occurs in healthy persons but is more common and more severe in immunocompromised patients. Three other viruses--Epstein-Barr virus, human papilloma virus, and human herpesvirus-8--are implicated in benign and malignant proliferative diseases of the gastrointestinal tract. Epstein-Barr virus has been associated with immunoproliferative disease after transplantation and may also cause small-bowel and colonic lymphoma in healthy adults. It causes most AIDS-related lymphomas. Human papillomaviruses cause anorectal condyloma and anal cancer. Human herpesvirus-8 causes gastrointestinal Kaposi sarcoma.

关键词：抗病毒药/治疗应用胃肠疾病/药物疗法胃肠疾病/流行病学胃肠疾病/病毒学发病率预后危险因素存活率美国/流行病学病毒性疾病/诊断病毒性疾病/药物疗法病毒性疾病/流行病学成年人女(雌)性人类男(雄)性

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