检索结果-内蒙古大学图书馆

Low-dose oral pulse methotrexate as monotherapy in elderly patients with bullous pemphigoid

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 1999年第5期40卷 741-749页

作者： Heilborn, JD Ståhle-Bäckdahl, M Albertioni, F Vassilaki, I Peterson, C Stephansson, E Karolinska Hosp Dept Dermatol & Venereol S-17176 Stockholm Sweden Karolinska Hosp Dept Clin Pharmacol S-17176 Stockholm Sweden

Background: Prednisone alone or in combination with an immunosuppressive drug is usually effective in controlling bullous pemphigoid. However, corticosteroids often cause potentially hazardous side effects, especially in elderly patients. Objective: Our purpose was to evaluate low-dose treatment with methotrexate in elderly patients with generalized bullous pemphigoid. Methods: Oral methotrexate, at an initial dosage of 5 mg/wk, was given to 11 consecutive patients older than 70 years of age who were not responding to potent topical steroids. If the response was insufficient, the methotrexate dose was increased by 2.5 mg/wk to a maximum of 12.5 mg/wk. Results: All patients responded with a marked and rapid decrease in disease activity. The disease was controlled in the majority of patients (8 of 11) with 5 to 7.5 mg of methotrexate per week. Three patients required a weekly dose of 10 to 12.5 mg. At 24 months of follow-up 7 patients were in complete remission and did not require methotrexate. Conclusion: Our study suggests that low-dose oral pulse methotrexate constitutes an effective therapeutic alternative in elderly patients with generalized bullous pemphigoid.

关键词：投药口服贫血/化学诱导皮肤科用药/投药和剂量皮肤科用药/副作用皮肤科用药/分析皮肤科用药/血液皮肤科用药/治疗应用渗出液和滤出液/化学随访研究糖皮质激素类/投药和剂量糖皮质激素类/治疗应用免疫抑制剂/投药和剂量免疫抑制剂/副作用免疫抑制剂/分析免疫抑制剂/血液免疫抑制剂/治疗应用甲氨蝶呤/投药和剂量甲氨蝶呤/副作用甲氨蝶呤/分析甲氨蝶呤/血液甲氨蝶呤/治疗应用类天疱疮大疱性/药物疗法类天疱疮大疱性/病理学泼尼松/投药和剂量泼尼松/治疗应用缓解诱导安全老年人老年人 80以上女(雌)性人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea

引用

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 1999年第6期40卷 961-965页

作者： Maddin, S Univ British Columbia Fac Med Div Dermatol Skin Care Ctr Vancouver BC V5Z 4E8 Canada

Background: Although it is important for physicians to have sufficient clinical data on which to base treatment decisions, little comparative data exist regarding newer treatment modalities for rosacea. Objective: The goal of the study was to compare the efficacy and safety of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea. Parameters of patient satisfaction to treatment were also assessed. Methods: Forty patients with the clinical manifestation of symmetric facial rosacea were investigated in this single-center, double-blind, randomized, contralateral split-face comparison clinical trial. Results: After 15 weeks of treatment, both azelaic acid and metronidazole induced significant, albeit equal reductions in the number of inflammatory lesions (pustules and papules). A significantly higher physician rating of global improvement was achieved with azelaic acid. Changes in the rosacea signs and symptoms of dryness, burning, telangiectasia, and itching were equal between treatments. A reduction in erythema tended toward significance with azelaic acid at week 15. A trace amount of stinging on application was noted with azelaic acid;however, such discomfort did not appear to concern patients because their overall impression of azelaic acid was superior to that of metronidazole. Conclusion: Azelaic acid 20% cream provides an effective and safe alternative to metronidazole 0.75% cream with the added benefit of increased patient satisfaction.

关键词：投药局部皮肤科用药/投药和剂量皮肤科用药/副作用二羧酸类/投药和剂量二羧酸类/副作用双盲法甲硝唑/投药和剂量甲硝唑/副作用软膏病人满意度红斑痤疮/药物疗法红斑痤疮/病理学成年人老年人人类中年人

来源：评论

学校读者我要写书评

暂无评论

Pulmonary toxicity in a patient with psoriasis receiving methotrexate therapy

引用

CLINICAL AND EXPERIMENTAL DERMATOLOGY 2000年第1期25卷 24-27页

作者： McKenna, KE Burrows, D Craigavon Area Hosp Grp Trust Dept Dermatol Portadown BT63 5QQ Craigavon North Ireland Royal Victoria Hosp Trust Belfast Antrim North Ireland

We report a 34-year-old woman with psoriasis who developed shortness of breath during methotrexate therapy. Methotrexate had been started 4 months earlier and the patient had ingested a cumulative dose of 232 mg. Pulmonary function tests showed a reduction in transfer factor to 76% of predicted. Methotrexate was stopped and her symptoms rapidly resolved. Pulmonary function tests deteriorated further despite stopping methotrexate but with no recurrence of symptoms with a transfer factor of 66% of predicted 2 months later. At 5 months after stopping methotrexate the patient remained well and pulmonary function had improved with a transfer factor of 79% of predicted. Pulmonary toxicity is a rare but important adverse effect of methotrexate therapy in patients with psoriasis.

关键词：皮肤科用药/副作用叶酸拮抗剂/副作用用力呼气量/生理学甲氨蝶呤/副作用银屑病/药物疗法呼吸障碍/化学诱导呼吸障碍/病理生理学肺活量/生理学成年人女(雌)性人类

来源：评论

学校读者我要写书评

暂无评论

Dermatomyositis-like eruption and leg ulceration caused by hydroxyurea in a patient with psoriasis

引用

CLINICAL AND EXPERIMENTAL DERMATOLOGY 1999年第3期24卷 164-166页

作者： Varma, S Lanigan, SW Univ Wales Hosp Dept Dermatol Cardiff CF4 4XN S Glam Wales Princess Wales Hosp Dept Dermatol Bridgend Wales

We report the case of an elderly woman who had been on hydroxyurea for long-standing widespread psoriasis, After approximate to 5 years's treatment with hydroxyurea, she developed a symmetrical dermatomyositis-like eruption on her hands, together with bilateral leg ulceration. Although similar skin eruptions have been reported after long-term hydroxyurea treatment, all of the previous patients were being treated for myeloproliferative disorders. A dermatomyositis-like eruption has not previously been reported to occur as a consequence of hydroxyurea treatment for psoriasis. Its recognition is important to prevent unnecessary investigation or treatment withdrawal.

关键词：皮肤科用药/投药和剂量皮肤科用药/副作用皮肌炎/化学诱导药疹/病因学羟基脲/投药和剂量羟基脲/副作用腿溃疡/化学诱导核酸合成抑制剂/投药和剂量核酸合成抑制剂/副作用银屑病/药物疗法老年人老年人 80以上女(雌)性人类

来源：评论

学校读者我要写书评

暂无评论

Severe anaphylaxis after a chlorhexidine bath

引用

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 1999年第5期40卷 771-772页

作者： Snellman, E Rantanen, T Paijat Hame Cent Hosp Dept Dermatol FIN-15850 Lahti Finland

Anaphylaxis to chlorhexidine is rare. We report a patient who experienced anaphylaxis during a whole body bath with chlorhexidine. Early signs of a type I allergy may have been masked because of previous concomitant t... 详细信息

关键词：投药皮肤过敏反应/化学诱导呼吸暂停/化学诱导浴/副作用头孢氨苄/投药和剂量头孢氨苄/治疗应用头孢菌素类/投药和剂量头孢菌素类/治疗应用氯己定/投药和剂量氯己定/副作用氯己定/类似物和衍生物皮炎刺激性/药物疗法皮肤科用药/投药和剂量皮肤科用药/副作用超敏反应速发型/化学诱导低血压/化学诱导 PUVA疗法痒疹/药物疗法人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

Nephrotoxic action of fumaric acid

引用

HAUTARZT 2000年第8期51卷 615-615页

作者： Mrowietz, U Univ Kiel Hautklin D-24105 Kiel Germany

来源：评论

学校读者我要写书评

暂无评论

暗疮药“保肤灵”可能有严重副作用

引用

首都医药 2002年第7期9卷 34页

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：