In spite of the promising therapeutic potential exhibited by the numerous antitumor nanomedicines,it remains a major challenge for particulate-based therapeutics to effectively transport into solid tumors,especially i...
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In spite of the promising therapeutic potential exhibited by the numerous antitumor nanomedicines,it remains a major challenge for particulate-based therapeutics to effectively transport into solid tumors,especially in stromal enriched *** recent progress on understanding the critical roles and the underlying mechanisms of tumor microenvironment on tumor rapid growth and metastasis has made targeting the tumor microenvironment becomes a feasible strategy to improve the effectiveness of nanomaterials-based cancer diagnosis and *** of stromal fibroblasts-specific enzymes and pathological changes of tumor vasculature are the most remarkable hallmarks of tumor microenvironment in almost all types of tumors and can be considered as good specific triggers or targets for design of broad-spectrum and localenvironment responsive functional nanomaterial-based *** we report novel biomimetic nanostructures based on oligopeptide self-assemblies that could quickly response and regulate the key components of tumor *** such a strategy,the optimal formulations were developed,showing the high activation efficacy and antitumor *** tailor-made self-assembled biomolecule nanomaterials have the potential to be used in early and late stages of solid tumors,especially for stromal enriched solid tumors,which is expected to be of crucial importance for clinical tumor *** additional research is urgent needed to develop robust methods for targeting and regulating nanomaterials to tumor sites and the supporting environment,the applications of tumor microenvironment-based nanotechnology for safer and more effective antitumor nanomedicine have so far been proven to be successful and will eventually revolutionize the current landscape of cancer therapy[1-7].
Metal oxide nanowires hold great promises for future optoelectronic, bio-chemical sensors with extremely small dimension and ultra-low power consumptions, arising from their unique properties and quasi-one-dimensional...
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Metal oxide nanowires hold great promises for future optoelectronic, bio-chemical sensors with extremely small dimension and ultra-low power consumptions, arising from their unique properties and quasi-one-dimensional geometrical *** vapor-liquid-solid（VLS） mechanism allows to design ordered oxide nanowire arrays, axial or core/shell heterostructures and branched nanowire structures from atomic scale, only limited oxides（ZnO,SnO,InO,GaO et al.） have been widely used till now, due to the limitation of material flux control via conventional vapor phase *** novel synthesis strategy is highly required for both fundamental research and real device application of nanowires.
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