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Boron neutron capture therapy of the rat 9L gliosarcoma: evaluation of the effects of shark cartilage

BRITISH JOURNAL OF RADIOLOGY 2000年第868期73卷 429-434页

作者： Morris, GM Coderre, JA Micca, PL Lombardo, DT Hopewell, JW Univ Oxford Churchill Hosp Res Inst Oxford OX3 7LJ England Brookhaven Natl Lab Dept Med Upton NY 11973 USA

A number of anti-angiogenic substances are now under evaluation, both experimentally and clinically, as potential agents for the treatment of cancer. It has recently been demonstrated that anti-angiogenic agents can increase the therapeutic potential of photon irradiation in a range of tumour models. In the present communication a preliminary assessment is made of the effects of shark cartilage on the response of the rat 9L gliosarcoma to boron neutron capture therapy (BNCT). Shark cartilage was administered orally as an aqueous suspension at a daily dose of similar to 2000 mg kg(-1) body weight. The mean survival time of rats receiving no treatment was 20.7+/-0.5 days post intracranial tumour implantation. Administration of shark cartilage alone extended the survival time. Two of the rats treated with shark cartilage were healthy and fully active at the end of the evaluation period (43 days post implantation). At autopsy the brain tumours of these animals were a factor of similar to 4 smaller than controls. In a repeat study with shark cartilage alone the survival time was extended by approximately 30%. After boronophenylalanine-mediated BNCT, with or without shark cartilage, the survival time of rats that eventually became moribund was increased by a factor of similar to 2 relative to controls. In both treatment groups similar to 20% of rats were healthy at 1 year after BNCT. There was no evidence of residual tumour at post-mortem It was concluded that shark cartilage, when given alone, significantly increased the survival time of tumour-bearing rats, presumably owing to an antiangiogenic effect. However, the survival data suggested that boronophenylalanine-mediated BNCT did not appear to be enhanced by the administration of shark cartilage.

关键词：血管生成抑制剂/治疗应用硼中子俘获疗法脑肿瘤/病理学脑肿瘤/放射疗法脑肿瘤/治疗软骨神经胶质肉瘤/病理学神经胶质肉瘤/放射疗法神经胶质肉瘤/治疗肿瘤移植辐射增敏药/治疗应用大鼠近交F344 鲨鱼存活率组织提取物/治疗应用肿瘤细胞培养的动物大鼠

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INTRA-ARTERIAL INFUSION OF SOLCOSERYL - CLINICAL TRIAL OF A METHOD OF TREATMENT FOR PRE-GANGRENE OF LOWER-LIMB

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BRITISH JOURNAL OF SURGERY 1975年第5期62卷 337-339页

作者： CHARLESWORTH, D HARRIS, PL PALMER, MK UNIV HOSP S MANCHESTER MANCHESTERENGLAND

A randomized double blind trial of the drug Solcoseryl given by intra‐arterial infusion was carried out on 57 patients with pre‐gangrene of the lower limb. A sequential analysis was carried out and the trial stopped... 详细信息

关键词：幼牛血清/投药和剂量幼牛血清/治疗应用动脉硬化/并发症坏疽/药物疗法坏疽/病因学输注胃肠外注射动脉内腿/外科学安慰剂组织提取物/治疗应用老年人女(雌)性人类男(雄)性

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Reviewer bias against the unconventional? A randomized double-blind study of peer review

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Complementary Therapies in Medicine 1999年第1期7卷 19-23页

作者： Ernst, E. Resch, K.-L. Division of Community Health Science Postgraduate Medical School University of Exeter Exeter EX4 4NT 25 Victoria Park Road United Kingdom University of Exeter Exeter United Kingdom

Objective:To test the hypothesis that there is a reviewer bias against publication of a test of an unconventional drug. Design: Randomized, controlled, double-blind study of peer review. Participants: Convenience sample of 291 medical doctors from a wide variety of specialties drawn from a list of conference participants. Methods: Reviewers were randomly assigned to receive one of two versions of a manuscript. Version M related to an in-vitro experiment on a mainstream drug (Metoprolol). The otherwise identical version V used a highly unconventional drug (beef spleen cell extract) for the same experiment. Reviewers were asked to complete a standardised evaluation sheet including visual analogue scales (VASs) on a set of pre-defined quality criteria. All participants were debriefed after completion of the study. Results: The response rate was 61%. There were no significant differences in VAS ratings between the two versions of the manuscript. Ratings covered the entire range of the VASs. Conclusion: In the present setting, there was no evidence for a reviewer-bias against testing an unconventional drug. The low inter-rater reliability, however, suggested inadequate validity of peer review.

关键词：补充疗法双盲法观察者偏差同行评议研究结果可重复性统计学非参数组织提取物/治疗应用动物牛人类

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胎肝细胞悬液治疗再生障碍性贫血15例的临床报告

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中华内科杂志 1983年第2期22卷 71-73+126页

作者：叶根耀吴祖泽钱凤伟余文英费瑞高蒋本荣程锡元李盈祺李春海肖蓬

本文总结胎肝细胞悬液治疗15例再生障碍性贫血(再障)的临床疗效和外周血象、淋巴细胞数及E-玫瑰花环、~3H-TdR转化率、骨髓象及其CFU-c测定等观察。在用雄性激素治疗基础上,4例有显著提升血红蛋白(Hb)及白细胞(WBC)作用,血小板恢复较慢... 详细信息

本文总结胎肝细胞悬液治疗15例再生障碍性贫血(再障)的临床疗效和外周血象、淋巴细胞数及E-玫瑰花环、~3H-TdR转化率、骨髓象及其CFU-c测定等观察。在用雄性激素治疗基础上,4例有显著提升血红蛋白(Hb)及白细胞(WBC)作用,血小板恢复较慢,未发现嵌合体。

关键词：肝移植贫血再生障碍性/治疗组织提取物/治疗应用

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复可托治疗扁平疣临床疗效观察及对IFN-γ和IL-4水平影响

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医学临床研究 2016年第2期33卷 319-321页

作者：姚颖嘉高春芳黄华李锋马骄阳上海中医药大学附属普陀医院皮肤与性病科止海200062

【目的】探讨复可托治疗扁平疣的临床疗效及对干扰素-γ（IFN-γ）和白细胞介素-4（IL-4）水平的影响。【方法】选取2011年2月至2014年5月来本院治疗的85例扁平疣患者为研究对象，随机分为对照组（41例）和观察组（44例）。两组患者均... 详细信息

【目的】探讨复可托治疗扁平疣的临床疗效及对干扰素-γ（IFN-γ）和白细胞介素-4（IL-4）水平的影响。【方法】选取2011年2月至2014年5月来本院治疗的85例扁平疣患者为研究对象，随机分为对照组（41例）和观察组（44例）。两组患者均采用外涂维A酸软膏治疗，每天一次，并每日取红花（6g）泡茶饮；观察组患者每天加服复可托（口服），每次2mg，每天一次；4周为1个疗程，两组治疗2个疗程后观察疗效；采用ELISA法检测IFN-γ、IL-4水平，比较两组患者治疗前后IFN-γ、IL-4的变化。【结果】治疗后，观察组总有效率93．18％显著高于对照组75．61％（x2=5．0585，P〈0．05）。治疗后，两组IFN-γ水平显著升高，IL-4水平显著降低，差异均具有统计学意义（P〈0．05），且观察组IL-4水平显著低于对照组，IFN-γ水平显著高于对照组，差异均具有统计学意义（P〈0．05）；治疗后两组CD3＋、CD4＋、CD4＋／CD8＋水平均明显升高，CD84＋水平明显降低，差异均具有统计学意义（P〈0．05），且观察组CD3＋、CD4＋、CD4＋／CD8＋均显著高于对照组，CD8＋显著低于对照组，差异均具有统计学意义（P〈0．05）。【结论】复可托口服治疗扁平疣疗效较好，通过改善患者T淋巴细胞亚群，提高IFN-γ水平，降低IL-4水平，增强患者免疫功能，有效除疣。

关键词：组织提取物/治疗应用疣/药物疗法干扰素Ⅱ型白细胞介素4

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胎肝细胞悬液短期内多次输注治疗再生障碍性贫血15例报告

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中华内科杂志 1985年第2期24卷 65-67+124页

作者：楼方定刘海川汪月增姚善谦张佐云孟凡义周绮张安胜张延红中国人民解放军总医院内科

本文报告了自1981年3月至1983年7月用胎肝细胞悬液短期内多次输注治疗再生障碍性贫血15例,共63人次。其中可供初步疗效评定的13例中,1例随访已17个月基本治愈,6例持续缓解已3～7个月,5例短暂有效,1例无效。对曾接受异性胎肝的14例进行... 详细信息

本文报告了自1981年3月至1983年7月用胎肝细胞悬液短期内多次输注治疗再生障碍性贫血15例,共63人次。其中可供初步疗效评定的13例中,1例随访已17个月基本治愈,6例持续缓解已3～7个月,5例短暂有效,1例无效。对曾接受异性胎肝的14例进行染色体核型分析,未发现异性染色体。文中指出本疗法显效较快,无不良反应,并对其机理等问题作了讨论。

关键词：贫血再生障碍性/治疗组织提取物/治疗应用

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松乐素对环磷酰胺所致小鼠白细胞减少防治作用实验研究的初步报告

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中华肿瘤杂志 1985年第5期7卷 344-347页

作者：李同度丁永为蚌埠医学院附属医院安徽省肿瘤医院

松果体与肿瘤生长的关系,不论在动物实验或是在临床方面至今尚难做出定论。蚌埠市第二人民医院1982年对松果体治疗恶性肿瘤249例分析观察提示松果体制剂能改善晚期癌瘤患者的全身情况,减轻放疗和化疗毒性反应并促使下降的白细胞数加快回... 详细信息

松果体与肿瘤生长的关系,不论在动物实验或是在临床方面至今尚难做出定论。蚌埠市第二人民医院1982年对松果体治疗恶性肿瘤249例分析观察提示松果体制剂能改善晚期癌瘤患者的全身情况,减轻放疗和化疗毒性反应并促使下降的白细胞数加快回升,从而提高患者继续接受放疗和化疗的耐受力。还有顾丽英(1982)的实验表明猪松果体提取物——松乐素

关键词：白细胞减少/化学诱导白细胞减少/预防和控制环磷酰胺/副作用组织提取物/治疗应用

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用蚯蚓提取物治疗原发性肾小球疾病的初步观察