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浙江大学学报（医学版） 2005年第5期34卷 427-431页

作者：王国凤来茂德陈培辉浙江大学医学院附属第二医院病理科浙江杭州310009 浙江大学医学院病理学与病理生理学教研室浙江杭州310031

目的:探讨多原发性肺癌与支气管上皮异型增生及肺泡上皮不典型腺瘤性增生之间的关系。方法:对114个手术切除的原发性肺癌标本进行病理组织学检查,观察多原发性肺癌的存在,支气管上皮异型增生,以及肺泡上皮不典型腺瘤性增生的数目,分析... 详细信息

目的:探讨多原发性肺癌与支气管上皮异型增生及肺泡上皮不典型腺瘤性增生之间的关系。方法:对114个手术切除的原发性肺癌标本进行病理组织学检查,观察多原发性肺癌的存在,支气管上皮异型增生,以及肺泡上皮不典型腺瘤性增生的数目,分析多原发性肺癌与支气管上皮异型增生及其程度,肺泡上皮不典型腺瘤性增生之间的关系。结果:在114个原发性肺癌标本中发现多原发性肺癌13例,其中6例2个原发性肺癌为支气管肺癌,7例2个原发性肺癌为支气管肺癌和肺泡细胞癌。经Spearman相关分析,多原发性肺癌与支气管上皮异型增生级别呈正相关(r=0.238,P<0.05)。结论:支气管及肺泡上皮细胞可同时或先后发生原发性肺癌;有广泛支气管上皮高级别异型增生者肺多原发性癌发生概率增高。

关键词：肺肿瘤/病理学肿瘤多原发性腺瘤/病理学增生肺泡/病理学支气管/病理学腺癌细支气管肺泡/病理学

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Proliferation indices in spontaneous canine lung cancer: Proliferating cell nuclear antigen (PCNA), Ki-67 (MIB1) and mitotic counts

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JOURNAL OF COMPARATIVE PATHOLOGY 1999年第4期120卷 321-332页

作者： Griffey, SM Kraegel, SA Madewell, BR Univ Calif Davis Sch Vet Med Dept Surg & Radiol Sci Davis CA 95616 USA

Proliferation indices were measured for specimens from 55 spontaneous canine lung tumours, collected by surgical biopsy from clinical patients and archived in paraffin wax blocks. These indices were then related to the mitotic index and histological type of the tumour. Proliferating cell nuclear antigen (PCNA) and Ki-67 (MIB1) proteins were detected immunohistochemically with a biotin-streptavidin amplified detection system on a representative tissue section from each tumour. Five adjacent, non-overlapping fields were selected at random, and 200 cells per field were examined in each section. For PCNA, cells were classified subjectively into negative, weak or strong reactivity groups, based on nuclear staining. MIB1 cells were classified as negative or positive, based on nuclear staining. Mitotic figures were counted in anti-PCNA-labelled and anti-MIB1-labelled sections, in the same tumour areas as those in which indices were established. Mitotic counts were also done on haematoxylin and eosin-stained tissue sections. Linear regression analysis showed that all PCNA, MIB1 and mitotic indices had highly significant positive correlations (P < 0.0001) with each other. Adenosquamous and squamous cell carcinomas differed from other histological tumour types in having significantly higher proliferation indices. These data suggest that growth rates for lung rumours in the dog vary according to histological type. On the basis of differences in proliferation indices and the distribution of immunoreactivity between histological subtypes in this study;it would seem that immunohistochemical detection of PCNA and MIB/1 reactivity and analysis of mitotic figures in routinely processed tissues may be useful in the diagnosis of lung tumours. (C) 1999 W.B. Saunders Company Limited.

关键词：腺癌/代谢腺癌/病理学腺癌/兽医学腺癌细支气管肺泡/代谢腺癌细支气管肺泡/病理学腺癌细支气管肺泡/兽医学抗原核癌/代谢癌/病理学癌/兽医学癌腺鳞状/代谢癌腺鳞状/病理学癌腺鳞状/兽医学癌鳞状细胞/代谢癌鳞状细胞/病理学癌鳞状细胞/兽医学细胞分裂/生理学狗疾病/代谢狗疾病/病理学免疫组织化学 Ki-67抗原/代谢肺肿瘤/代谢肺肿瘤/病理学肺肿瘤/兽医学有丝分裂指数核蛋白质类/代谢增殖细胞核抗原/代谢回归分析动物狗

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Induction of cytochrome P-450 1A1 in human hepatoma HepG2 and lung carcinoma NCI-H322 cells by motorcycle exhaust particulate

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JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 2000年第2期60卷 101-119页

作者： Ueng, TH Hu, SH Chen, RM Wang, HW Kuo, ML Natl Taiwan Univ Coll Med Inst Toxicol Taipei 10018 Taiwan

The effects of motorcycle exhaust particulate (MEP) on human cytochrome P-450 (P-450)-dependent monooxygenases were determined using human hepatoma cell line HepG2 and lung carcinoma cell line NCI-H322 treated with organic extracts of MEP from a two-stroke engine. Gas chromatography and mass spectrometry analysis of MEP extract revealed the presence of carcinogens benzo[a]pyrene, benz[a]anthracene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[g,h,i]perylene, chrysene, and indeno[1,2,3-c,d]pyrene in the chemical mixture. Treatment with MEP extract produced concentration- and time-dependent increases of monooxygenase activity in HepG2 cells. Treatment of the cells with 100 mu g/ml MEP extract for 24 h markedly increased benzo[a]pyrene hydroxylation, 7-ethoxycoumarin. and 7-ethoxyresorufin O-deethylation activities in microsomes. Immunoblot analysis of microsomal proteins using mouse monoclonal antibody 1-12-3 against P-450 1A1 revealed that MEP extract induced a P-450-immunorelated protein in the hepatoma cells. RNA blot analysis of cellular total RNA using a human P-450 1A1 3'-end cDNA probe showed that MEP extract increased the level of a hybridizable P-450 mRNA. These P-450 IA i inductive effects of MEP extract were similar to those from treatment with 10 mu M benzo[a]pyrene or 3-methylcholanthrene (3-MC) in HepG2 cells. Treatment of lung carcinoma NCI-H322 cells with 100 mu g/ml MEP extract 10 mu M benzo[a]pyrene, or 3-MC resulted in induction of monooxygenase activity, protein, and mRNA of P-450 IA I, similar to the induction observed with the hepatoma cells. The present study demonstrates that MEP extract has the ability to induce human hepatic and pulmonary P-450 1A1 in the liver- and lung-derived cell lines, and the induction involves a pretranslational mechanism. Induction of the human hepatic and pulmonary P-450 1A1 in vitro may provide important information in the assessment of MEP metabolism and toxicity in humans.

关键词：腺癌细支气管肺泡/酶学腺癌细支气管肺泡/病理学空气污染物/分析空气污染物/毒性致癌物/分析致癌物/毒性癌肝细胞/酶学癌肝细胞/病理学细胞色素P450CYP1A1/生物合成细胞色素P450CYP1A1/遗传学电泳聚丙烯酰氨凝胶酶诱导/药物作用气相色谱-质谱法免疫印迹法肝肿瘤/酶学肝肿瘤/病理学肺肿瘤/酶学肺肿瘤/病理学摩托车 RNA 信使/药物作用 RNA 信使/分离和提纯肿瘤细胞培养的车辆排放物/分析车辆排放物/毒性人类

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Bronchioloalveolar carcinoma arising in a bronchogenic cyst

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ANNALS OF THORACIC SURGERY 2000年第3期69卷 933-935页

作者： Endo, C Imai, T Nakagawa, H Ebina, A Kaimori, M Aomori Prefertural Cent Hosp Dept Resp Dis Aomori Japan Aomori Prefertural Cent Hosp Dept Pathol Aomori Japan

We report the case of a 37-year-old woman with a radiographically cystic lung lesion. Lobectomy was performed. Histopathologic examination showed a bronchioloalveolar carcinoma arising in a bronchogenic cyst. This suggests that epithelial cells of bronchogenic cysts can undergo malignant transformation. It may be prudent to recommend complete resection of any bronchogenic cyst. (C) 2000 by The Society of Thoracic Surgeons.

关键词：腺癌细支气管肺泡/并发症腺癌细支气管肺泡/病理学支气管源性囊肿/并发症支气管源性囊肿/病理学肺肿瘤/并发症肺肿瘤/病理学成年人女(雌)性人类

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Prognostic value of bronchiolo-alveolar carcinoma component of small lung adenocarcinoma

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ANNALS OF THORACIC SURGERY 1999年第6期68卷 2069-2073页

作者： Higashiyama, M Kodama, K Yokouchi, H Takami, K Mano, M Kido, S Kuriyama, K Osaka Med Ctr Canc & Cardiovasc Dis Dept Thorac Surg Higashinari Ku Osaka 5378511 Japan Osaka Med Ctr Canc & Cardiovasc Dis Dept Pathol Higashinari Ku Osaka 5378511 Japan Osaka Med Ctr Canc & Cardiovasc Dis Dept Radiol Higashinari Ku Osaka 5378511 Japan

Background. Bronchiolo-alveolar carcinoma (BAC) is often observed in lung adenocarcinoma, but its clinicopathological and prognostic significance, especially in small peripheral lung adenocarcinoma, remains undetermined. Methods. We assessed 206 consecutive cases of surgically resected small peripheral lung adenocarcinoma (less than 2 cm in diameter) recorded between 1973 and 1997. According to the component area of well differentiated BAC within maximally cut surface specimens of tumor tissue, we semiquantitatively classified the tumors into four types: those in which the BAC component comprised 0% (type I), 1% to 49% (type II), 50% to 99% (type III), and 100% (type IV) of the tumor tissue. Results. Forty tumors were classified as type I, 75 as type II, 74 as type III, and 17 as type IV. The tumors with less BAG, especially type I and II, showed a significantly more aggressive nodal involvement and tumor stage, and consequently a worse prognosis, while type IV tumors had no nodal involvement and the most favorable prognosis. The patients with type III showed clinicopathological characteristics somewhere between those of type II and type IV patients. Among stage I patients, however, those with type II had the worst prognosis, while those with type I showed as good a prognosis as the other two groups. Conclusions. This novel classification based on the degree of BAC involvement in small peripheral lung adenocarcinoma may reflect clinicopathological and prognostic characteristics. This classification may prove practical for planning therapeutic strategies, in particular surgical treatment. (C) 1999 by The Society of Thoracic Surgeons.

关键词：腺癌/死亡率腺癌/病理学腺癌/继发性腺癌/外科学腺癌细支气管肺泡/死亡率腺癌细支气管肺泡/病理学腺癌细支气管肺泡/继发性腺癌细支气管肺泡/外科学肺肿瘤/死亡率肺肿瘤/病理学肺肿瘤/外科学淋巴结切除术肺切除术预后存活率女(雌)性人类男(雄)性中年人

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Cutting needle biopsy in the diagnosis of clinically suspected non-carcinomatous disease of the lung

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BRITISH JOURNAL OF RADIOLOGY 2000年第875期73卷 1235-1236页

作者： Morcos, SK No Gen Hosp Xray Dept Sheffield S5 7AU S Yorkshire England

Most patients referred for lung biopsy have a focal lesion that is likely to be a carcinoma, and fine needle aspiration is usually sufficient to confirm the diagnosis. When non-carcinomatous disease is suspected, tissue architecture is important and potential diagnostic techniques include percutaneous cutting needle biopsy (CNB). We retrospectively reviewed 37 CNBs performed for clinically suspected non-carcinomatous disease; recording the biopsy result, final diagnosis, radiological nature of the pulmonary abnormality, distance from the pleura of the lesion biopsied and biopsy complications. 9 patients had a single pulmonary nodule/mass; 13 had multiple nodules/masses; 8 had a lobar consolidation/mass; and 7 had multifocal consolidation. The lesion abutted the pleura in 31 cases, lying within 1 cm in the other 6 cases. The minor complication rate was 14%, with no major complications. Specific malignant diagnoses were made in 9 patients, and specific benign in 23, in all of whom clinicoradiological follow-up was concordant. CNB did not yield a specific diagnosis in five patients, including two lymphomas and one case of unsuspected tuberculosis in which the sample was not cultured. The overall accuracy of CNB was 32/37 (86%). CNB is a safe and accurate means of achieving a tissue diagnosis for patients with peripheral pulmonary parenchymal disease thought not to represent carcinoma.

关键词：腺癌细支气管肺泡/病理学腺癌细支气管肺泡/放射摄影术活组织检查针吸/方法诊断鉴别肺疾病/病理学肺疾病/放射摄影术肺肿瘤/病理学肺肿瘤/放射摄影术淋巴瘤/病理学淋巴瘤/放射摄影术回顾性研究成年人老年人女(雌)性人类男(雄)性中年人

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细支气管-肺泡癌37例的临床、X线、病理分析

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中华结核和呼吸杂志 1981年第6期4卷 361-364+394页

作者：孙忠亮李锡莹贾友明高育瑶洪应中徐从德王哨湘陈忠年中山医院肺病学教研室中山医院放射学教研室上海第一医学院病理学教研室

本文总结经病理证实的BAC37例,其中30例孤立结节型经手术切除,7例为弥漫型。孤立型的临床表现与一般支气管肺癌无异。弥漫型的主要临床表现为进行性呼吸困难和发绀,咳大量水样粘液痰者仅1例。癌灶可以融合,呈实变和炎症浸润状。X线上孤... 详细信息

本文总结经病理证实的BAC37例,其中30例孤立结节型经手术切除,7例为弥漫型。孤立型的临床表现与一般支气管肺癌无异。弥漫型的主要临床表现为进行性呼吸困难和发绀,咳大量水样粘液痰者仅1例。癌灶可以融合,呈实变和炎症浸润状。X线上孤立型病灶的边缘轮廓可以不清,多见毛刺、分叶、尾巴征、兔耳征,特别是空泡征和支气管充气征对诊断意义更大。病理组织上BAC可分为肺泡型和裂隙型二种。慢性炎症,纤维瘢痕可能是BAC癌变的诱因。

关键词：肺肿瘤/病理学腺癌细支气管肺泡/病理学人类

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细支气管肺泡细胞癌——Clara细胞性腺癌6例报告

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中华肿瘤杂志 1986年第3期8卷 209-211+242页

作者：黄志英张海清应芸书北京结核病肺肿瘤研究所病理室中国科学院生物物理研究所电镜室

细支气管肺泡细胞癌是一特殊类型的原发性支气管肺癌,组织发生学尚未完全澄清。近年来由于电子显微镜的广泛应用,对其形态和组织发生学有深一步的认识。本文通过光学和电子显微镜的观察,对这一肿瘤的发生来源作进一步的探讨。

关键词：肺肿瘤/病理学腺癌细支气管肺泡/病理学

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细支气管肺泡癌32例分析

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中华结核和呼吸杂志 1992年第4期15卷 230-230页

作者：杨文礼高连鹏句少华 云清张培荣高艳芳哈尔滨医科大学附属第二医院哈尔滨市北方中医肿瘤研究所大庆石油学院校医院哈尔滨市结核病防治所牡丹江市林业中心医院

1981年5月～1990年3月收住院的细支气管肺泡癌共32例占同期830例肺癌的总住院人数的3.8%,全部皆经痰脱落细胞及病理活检证实为肺泡癌。男性14例,女性18例,男女之比为1∶1.29,年龄16～78岁。临床表现有咳嗽、痰中带血、胸痛、胸闷、发热... 详细信息

1981年5月～1990年3月收住院的细支气管肺泡癌共32例占同期830例肺癌的总住院人数的3.8%,全部皆经痰脱落细胞及病理活检证实为肺泡癌。男性14例,女性18例,男女之比为1∶1.29,年龄16～78岁。临床表现有咳嗽、痰中带血、胸痛、胸闷、发热及呼吸困难。

关键词：肺肿瘤/病理学腺癌细支气管肺泡/病理学

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细支气管肺泡细胞癌脉络膜转移一例

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中华眼科杂志 1990年第2期26卷 110-110页

作者：王军宋琛中国人民解放军总医院眼科

患者女,49岁,于1986年10月20日突然发现左眼视物模糊,鼻下方黑影遮挡,当地医院诊断为"双眼屈光不正"。10天后左眼前黑影扩大,在当地医院做眼眶CT扫描、B超及荧光造影检查,诊断为:(1)左眼继发性视网膜脱离;(2)脉络膜黑色素瘤... 详细信息

患者女,49岁,于1986年10月20日突然发现左眼视物模糊,鼻下方黑影遮挡,当地医院诊断为"双眼屈光不正"。10天后左眼前黑影扩大,在当地医院做眼眶CT扫描、B超及荧光造影检查,诊断为:(1)左眼继发性视网膜脱离;(2)脉络膜黑色素瘤可能性大。于1986年12月18日收入我科。患者曾于1970年行子宫肌瘤切除术。1984年消化道出血,原因不

关键词：肺肿瘤/病理学脉络膜肿瘤/继发性腺癌细支气管肺泡/病理学肿瘤转移人类

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