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检索条件"主题词=细胞毒性/代谢"
9 条 记 录,以下是1-10 订阅
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Heat shock proteins as mediators of aggregation-induced 'danger' signals: implications of the slow evolutionary fine-tuning of sequences for the antigenicity of cancer cells
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CELL STRESS & CHAPERONES 1999年 第4期4卷 205-210页
作者: Forsdyke, DR Queens Univ Dept Biochem Kingston ON K7L 3N6 Canada
Organisms 'tune' to their environment through adaptations which confer a selective advantage. However, in complex systems, a primary change of positive adaptive value might have multiple minor secondary effect... 详细信息
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Induction of rapid histone degradation by the cytotoxic T lymphocyte protease granzyme A
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JOURNAL OF BIOLOGICAL CHEMISTRY 2001年 第5期276卷 3683-3690页
作者: Zhang, D Pasternack, MS Beresford, PJ Wagner, L Greenberg, AH Lieberman, J Harvard Univ Sch Med Ctr Blood Res Boston MA 02115 USA Harvard Univ Massachusetts Gen Hosp Sch Med Boston MA 02115 USA Harvard Univ Sch Med Dept Pediat Boston MA 02115 USA Univ Manitoba Manitoba Inst Cell Biol Winnipeg MB R3E 0V9 Canada
The cytotoxic T lymphocyte protease granzyme A induces caspase-independent cell death in which DNA single-strand nicking is observed instead of oligonucleosomal fragmentation. Granzyme A is a specific tryptase that co... 详细信息
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Interferon-γ reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells
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AMERICAN JOURNAL OF PATHOLOGY 2002年 第2期160卷 521-528页
作者: Le Poole, IC Riker, AI Quevedo, ME Stennett, LS Wang, E Marincola, FM Kast, WM Robinson, JK Nickoloff, BJ Loyola Univ Med Ctr Canc Immunol Program Maywood IL 60153 USA Cardinal Bernardin Canc Ctr Dept Pathol Skin Oncol Res Program Maywood IL USA NIH Surg Branch Bethesda MD 20892 USA
In malignant melanoma, tumor-infiltrating lymphocytes are frequently reactive with melanosomal antigens. Achieving complete remissions by peptide therapy is frequently hampered by metastases evading immune recognition... 详细信息
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Anti-third party CD8+ CTLs as potent veto cells:: Coexpression of CD8 and FasL is a prerequisite
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IMMUNITY 2000年 第4期13卷 507-515页
作者: Reich-Zeliger, S Zhao, Y Krauthgamer, R Bachar-Lustig, E Reisner, Y Weizmann Inst Sci Dept Immunol IL-76100 Rehovot Israel
Several bone marrow cells and lymphocyte subpopulations, known as "veto cells," were shown to induce transplantation tolerance across major histocompatibility antigens. Recently, it has been suggested that a... 详细信息
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ISOLATION OF MONONUCLEAR CYTOTOXIC-CELLS FROM CATTLE VACCINATED AGAINST FOOT-AND-MOUTH-DISEASE
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ARCHIVES OF VIROLOGY 1992年 第3-4期122卷 293-306页
作者: AMADORI, M ARCHETTI, IL VERARDI, R BERNERI, C SPEDALI CIVIL BRESCIA BIOTECHNOL LAB BRESCIA ITALY
Mononuclear cells from peripheral blood leucocytes of foot-and-mouth disease (FMD) vaccinated cattle underwent blast transformation after in vitro culture with purified, inactivated, 146 S FMD virus antigen. From the ... 详细信息
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Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: Implications for TCR signaling
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IMMUNITY 2000年 第4期13卷 475-484页
作者: Baker, BM Gagnon, SJ Biddison, WE Wiley, DC Harvard Univ Dept Mol & Cellular Biol Cambridge MA 02138 USA Howard Hughes Med Inst Cambridge MA 02138 USA NINDS Mol Immunol Sect Neuroimmunol Branch NIH Bethesda MD 20892 USA
The structure of the A6 alpha beta TCR/HTLV-1 Tax-peptide/MHC I complex with proline 6 of Tax substituted with alanine (P6A), an antagonist, is nearly identical to the structure with wild-type Tax agonist. Neither the... 详细信息
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Activation of infiltrating cytotoxic T lymphocytes and lymphoma cell apoptotic rates in gastric MALT lymphomas -: Differences between high-grade and low-grade cases
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AMERICAN JOURNAL OF PATHOLOGY 1999年 第3期155卷 823-829页
作者: Guidoboni, M Doglioni, C Laurino, L Boiocchi, M Dolcetti, R Ctr Riferimento Oncol Div Expt Oncol 1 I-33081 Aviano PN Italy Belluno City Hosp Dept Pathol Belluno Italy
In this study, we have characterized infiltrating T lymphocytes from 13 low-grade and 17 high-grade primary gastric MALT lymphomas by immunohistochemistry, with particular regard to the presence, activation, and topog... 详细信息
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Acute generalized exanthematous pustulosis - Role of cytotoxic T cells in pustule formation
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AMERICAN JOURNAL OF PATHOLOGY 2002年 第6期161卷 2079-2086页
作者: Schmid, S Kuechler, PC Britschgi, M Steiner, UC Yawalkar, N Limat, A Baltensperger, K Braathen, L Pichler, WJ Inselspital Bern Clin Rheumatol & Clin Immunol Allergol CH-3010 Bern Switzerland Inselspital Bern Clin Dermatol CH-3010 Bern Switzerland Univ Bern Dept Pharmacol Bern Switzerland Modex Therapeut Lausanne Switzerland
Extensive formation of nonfollicular sterile pustules on erythematous background combined with fever and peripheral blood leukocytosis are the characteristics of acute generalized exanthematous pustulosis. This uncomm... 详细信息
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The identification of myriocin-binding proteins (vol 6, pg 221, 1999)
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CHEMISTRY & BIOLOGY 1999年 第6期6卷 R186-R186页
作者: Chen, JK Lane, WS Schreiber, SL Howard Hughes Medical Institute Department of Chemistry and Chemical Biology Harvard University 12 Oxford Street Cambridge MA 02138 USA Harvard Microchemistry Facility Harvard University 16 Divinity Avenue Cambridge MA 02138 USA
BACKGROUND: Myriocin is a natural product that potently induces apoptosis of a murine cytotoxic T lymphocyte cell line (CTLL-2) and inhibits a serine palmitoyltransferase (SPT) activity that has been detected in cell ... 详细信息
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