A hallmark of the mammalian circadian timing system is synchronization of physiology and behavior,but when this synchronization is disturbed,chronic diseases such as metabolic syndrome and depression may *** new studi...
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A hallmark of the mammalian circadian timing system is synchronization of physiology and behavior,but when this synchronization is disturbed,chronic diseases such as metabolic syndrome and depression may *** new studies show that nuclear receptors of the Rev-Erb family impact the circadian oscillator and its metabolic output and this can be modified with specific ***,resynchronization of metabolic pathways by manipulation of the circadian oscillator using REVERB-specific agonists may represent a feasible therapeutic concept to target diseases rooted in a misaligned circadian system.
作者：
H Eric XUVARI-SIMM Center
Center for Structure and Function of Drug Targets State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Laboratory of Structural Sciences
Van Andel Research Institute Grand Rapids MI 49503 USA
Hormones comprise one of the most effective classes of messengers that transmit cell to cell communication in eukaryotic *** receive messages of hormones through protein receptors,and then translate the hormone signal...
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Hormones comprise one of the most effective classes of messengers that transmit cell to cell communication in eukaryotic *** receive messages of hormones through protein receptors,and then translate the hormone signals into concrete action of physiological responses.
While nuclear receptors(NRs)generally function as transcriptional regulators of diverse metabolic, developmental and proliferative processes, some NRs also appear to modulate inflammatory processes such as those direc...
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While nuclear receptors(NRs)generally function as transcriptional regulators of diverse metabolic, developmental and proliferative processes, some NRs also appear to modulate inflammatory processes such as those directed by Toll-like receptor(TLR)signaling in macrophages and other cell types of the innate immune system[1,2].The medical and pharmaceutical interest in these pathways is considerable since NRs are valid drug targets and inflammatoryprocesses have emerged as intrinsic components of metabolic diseases such as obesity, diabetes and atherosclerosis.
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