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检索条件"主题词=胰岛素样生长因子Ⅰ/药理学"
88 条 记 录,以下是41-50 订阅
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Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents
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MOLECULAR ENDOCRINOLOGY 2000年 第7期14卷 1086-1098页
作者: Apostolakis, EM Gerai, J Lohmann, JE Clark, JH O'Malley, BW Baylor Coll Med Dept Cell Biol Houston TX 77030 USA Univ Pecs Sch Med Dept Pathophysiol Pecs Hungary
Sex steroids exert profound influence on neural development and function through activation of intranuclear receptors. However, during sexual differentiation and at onset of puberty, intracerebral estrogen (E) availab... 详细信息
来源: 评论
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-Myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第49期275卷 38261-38267页
作者: Law, BK Waltner-Law, ME Entingh, AJ Chytil, A Aakre, ME Norgaard, P Moses, HL Vanderbilt Univ Vanderbilt Ingram Canc Ctr Nashville TN 37232 USA Vanderbilt Univ Dept Cell Biol Nashville TN 37232 USA Vanderbilt Univ Dept Mol Physiol & Biophys Nashville TN 37232 USA Glostrup Univ Hosp Inst Pathol Anat DK-2600 Glostrup Denmark
Salicylate and its pro-drug form aspirin are widely used medicinally for their analgesic and anti-inflammatory properties, and more recently for their ability to protect against colon cancer and cardiovascular disease... 详细信息
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Expression and release of insulin-like growth factor binding proteins in isolated epiphyseal growth plate chondrocytes from the ovine fetus
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JOURNAL OF CELLULAR PHYSIOLOGY 2000年 第2期183卷 172-181页
作者: De los Rios, P Hill, DJ Univ Western Ontario St Josephs Hlth Ctr Lawson Res Inst London ON N6A 4V2 Canada Univ Western Ontario Dept Physiol London ON Canada Univ Western Ontario Dept Med London ON Canada Univ Western Ontario Dept Paediat London ON Canada
Insulin-like growth factor-ii (IGF-II) is an autocrine modulator of epiphyseal chondrogenesis in the fetus. The cellular availability of ICFs are influenced by the IGF-binding proteins (ICFBPs). In this study, we inve... 详细信息
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Effects of recombinant human insulin-like growth factor I administration on spontaneous and growth hormone (GH)-releasing hormone-stimulated GH secretion in anorexia nervosa
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2000年 第8期85卷 2805-2809页
作者: Gianotti, L Pincelli, AI Scacchi, M Rolla, M Bellitti, D Arvat, E Lanfrano, F Torsello, A Ghigo, E Cavagnini, F Müller, EE Univ Milan Dept Pharmacol I-20129 Milan Italy Univ Pisa Univ Adolescentol I-56100 Pisa Italy Univ Milan San Luca Hosp Chair Endocrinol 2 I-20149 Milan Italy Univ Turin Dept Internal Med Div Endocrinol I-10126 Turin Italy
Exaggerated GH and reduced insulin-like growth factor I (IGF-I) level are common features in anorexia nervosa (AN). A reduction of the negative IGF-I feedback could account, in part, for GH hypersecretion. To ascertai... 详细信息
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Synergistic effects of insulin-like growth factor-I and human chorionic gonadotropin in the rat ovary
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METABOLISM-CLINICAL AND EXPERIMENTAL 2000年 第3期49卷 314-320页
作者: Damario, MA Bogovich, K Liu, HC Rosenwaks, Z Poretsky, L Cornell Univ Med Ctr New York Hosp Dept Obstet & Gynecol New York NY 10021 USA Cornell Univ Med Ctr New York Hosp Dept Med New York NY 10021 USA Univ S Carolina Sch Med Dept Obstet & Gynecol Columbia SC USA
Insulin and low doses of luteinizing hormone (LH) activity (human chorionic gonadotropin [hCG]) act synergistically in the rat to produce anovulation, large ovarian cysts, and elevated plasma androstenedione levels. F... 详细信息
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Proliferation of mouse mammary epithelial cells in vitro:: Interactions among epidermal growth factor, insulin-like growth factor I, ovarian hormones, and extracellular matrix proteins
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ENDOCRINOLOGY 2000年 第10期141卷 3578-3586页
作者: Woodward, TL Xie, JW Fendrick, JL Haslam, SZ Michigan State Univ Dept Physiol E Lansing MI 48824 USA
The purpose of the present study was to investigate the role of extracellular matrix proteins (ECMs;collagens I and IV, fibronectin, and laminin) in modulating proliferative responses of normal mammary epithelial cell... 详细信息
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Stat 5B, activated by insulin in a Jak-independent fashion, plays a role in Glucokinase gene transcription
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ENDOCRINOLOGY 2000年 第6期141卷 1977-1988页
作者: Sawka-Verhelle, D Tartare-Deckert, S Decaux, JF Girard, J Van Obberghen, E INSERM U145 Fac Med F-06107 Nice 2 France CNRS UPR 1524 F-92190 Meudon France
Stat proteins are SH2 domain-containing transcription factors that are activated by various cytokines and growth factors. In a previous work, we have identified Stat 5B as a substrate of the insulin receptor based on ... 详细信息
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Insulin-like growth factor binding protein-3 is regulated by dihydrotestosterone and stimulates deoxyribonucleic acid synthesis and cell proliferation in LNCaP prostate carcinoma cells
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ENDOCRINOLOGY 2000年 第7期141卷 2401-2409页
作者: Martin, JL Pattison, SL Univ Sydney Royal N Shore Hosp Kolling Inst Med Res St Leonards NSW 2065 Australia
We have investigated the production and actions of a growth regulatory protein, insulin-like growth factor binding protein (TGFBP)-3, in the androgen-responsive prostate carcinoma cell line LNCaP. Confluent monolayers... 详细信息
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Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation
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ENDOCRINOLOGY 2000年 第5期141卷 1667-1674页
作者: Deckers, MML Karperien, M van der Bent, C Yamashita, T Papapoulos, SE Löwik, CWGM Leiden Univ Med Ctr Dept Endocrinol & Metab Dis NL-2333 ZA Leiden Netherlands Leiden Univ Med Ctr Dept Pediat NL-2333 ZA Leiden Netherlands Kirin Brewery Co Ltd Pharmaceut Res Lab Takasaki Gumma 37012 Japan
Endochondral bone formation is regulated by systemically and locally acting growth factors. A role for vascular endothelial growth factor (VEGF) in this process has recently been proposed, because inactivation of VEGF... 详细信息
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Dietary protein restriction lowers plasma insulin-like growth factor I (IGF-I), impairs cortical bone formation, and induces osteoblastic resistance to IGF-I in adult female rats
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ENDOCRINOLOGY 2000年 第9期141卷 3149-3155页
作者: Bourrin, S Ammann, P Bonjour, JP Rizzoli, R Univ Hosp Geneva Dept Internal Med Div Bone Dis WHO Collaborating Ctr Osteoporosis & Bone Dis CH-1211 Geneva 14 Switzerland
Dietary protein deficiency, common in elderly, is associated with decreased areal bone mineral density and plasma insulin-like growth factor I (IGF-I). To investigate the early adaptation of bone cells to protein rest... 详细信息
来源: 评论