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1 病例报告例1:男,9岁.因发热2个月余伴头痛入院.病初曾有咳嗽、头痛(为阵发性前额部隐痛,体温升高时头痛加剧),既往无头痛发作史.查体:神志清楚,精神差,呼吸平稳,神经系统未见异常.查肝肾功能正常,血常规及血涂片检查未发现异常,支原体抗体1∶320阳性;脑电图检查提示清醒期呈弥漫性4～6 Hz高幅漫波;脑脊液压力正常,细胞数60×106/L,蛋白质876 mg/L,糖和氯化物正常,脑脊液支原体抗体1∶160阳性.诊断为支原体脑炎.

关键词：脑炎/微生物学支原体感染

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马红球菌性脑炎1例

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中国误诊学杂志 2004年第7期4卷 1157-1158页

作者：胡玉蕾李献珍汤春辉曹志琅付红敏云南省第一人民医院儿科 650032

1 病例报告女,11岁.以反复发热50 d,伴抽搐2 d为主诉,于2003-08-27就诊.50 d前因发热,左侧肢体强直阵挛样发作6次,不伴意识障碍,持续2～3 min缓解,无头痛及呕吐,在外院诊断为病毒性脑炎,先后给予头孢拉啶、头孢噻肟、阿昔洛韦、无环乌... 详细信息

1 病例报告女,11岁.以反复发热50 d,伴抽搐2 d为主诉,于2003-08-27就诊.50 d前因发热,左侧肢体强直阵挛样发作6次,不伴意识障碍,持续2～3 min缓解,无头痛及呕吐,在外院诊断为病毒性脑炎,先后给予头孢拉啶、头孢噻肟、阿昔洛韦、无环乌苷、异烟肼、利福平等治疗,患儿仍发热.

关键词：红球菌马脑炎/微生物学放线菌目感染

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Lanoconazole, a new imidazole antimycotic compound, protects MAIDS mice against encephalitis caused by Cryptococcus neoformans

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JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2000年第3期46卷 443-450页

作者： Furukawa, K Sasaki, H Pollard, RB Suzuki, F Univ Texas Med Branch Galveston TX 77555 USA

The protective effect of a new antifungal compound, lanoconazole, against Cryptococcus neoformans infection in C57BL/6 mice exposed to LP-BM5 murine leukaemia virus (MuLV) (MAIDS mice) was investigated. Mice were infected intratracheally with C. neoformans, strain 613D, 40 days after infection with LP-BM5 MuLV. They were treated orally with various doses of lanoconazole or with fluconazole 10 mg/kg (a positive control) once daily beginning 1 day after the fungal infection and continuing until the end of the experimental period. The number of C. neoformans cells in the lungs and brains of infected mice was determined. Lanoconazole and fluconazole had a similar inhibitory effect on the growth of C. neoformans in the brains and lungs of normal mice. Whereas lanoconazole inhibited the growth of C. neoformans in the brains and lungs of MAIDS mice, the pathogen grew in the brains of MAIDS mice treated with fluconazole. Lanoconazole reduced the number of C. neoformans in the brains of normal mice treated with a type 2 cytokine mixture, whereas fluconazole did not. A predominance of type 2 T-cell responses was demonstrated in MAIDS mice. Splenic T cells from MAIDS mice, but not those from normal mice, released interleukins 4 and 10 into the culture medium when they were stimulated with an anti-CD3 monoclonal antibody. These results suggest that lanoconazole may have the potential to inhibit the growth of C. neoformans in AIDS patients with a predominance of type 2 T-cell responses.

关键词：抗真菌药/治疗应用脑/微生物学隐球菌病/并发症隐球菌病/药物疗法隐球菌病/免疫学隐球菌病/微生物学新型隐球菌/生长和发育细胞因子类/生物合成细胞因子类/治疗应用脑炎/并发症脑炎/药物疗法脑炎/免疫学脑炎/微生物学氟康唑/治疗应用杂环化合物/治疗应用咪唑类/治疗应用肺/微生物学小鼠近交C57BL 鼠获得性免疫缺陷综合征/并发症鼠获得性免疫缺陷综合征/免疫学鼠获得性免疫缺陷综合征/微生物学机会致病菌感染/并发症机会致病菌感染/药物疗法机会致病菌感染/免疫学机会致病菌感染/微生物学脾/细胞学 Th2细胞/免疫学动物小鼠

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Repeated oral dosing with Listeria monocytogenes in mice as a model of central nervous system listeriosis in man

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JOURNAL OF COMPARATIVE PATHOLOGY 1999年第2期121卷 117-125页

作者： Altimira, J Prats, N López, S Domingo, M Briones, V Domínguez, L Marco, A Univ Autonoma Barcelona Fac Vet Dept Patol & Prod Anim Bellaterra 08193 Spain Univ Complutense Madrid Fac Vet Dept Patol Anim 1 E-28040 Madrid Spain

Human listeriosis is a food-borne disease of immunosuppressed or previously healthy adults. The repeated oral administration of a sublethal dose (5 x 10(9) colony-forming units) of Listeria monocytogenes for 7 or 10 consecutive days led to the development of severe central nervous system (CNS) lesions in 25% of experimental mice. Histopathological examination of the brain revealed rhombencephalitis and ventriculitis as two distinct inflammatory patterns, resembling those seen in human listeriosis. This model would seem to be potentially useful for research on pathogenesis: predisposing factors and therapy in CNS listeriosis in man. (C) 1999 W.B. Saunders Company Limited.

关键词：投药口服抗原细菌/代谢脑干/代谢脑干/病理学中枢神经系统疾病/微生物学中枢神经系统疾病/病理学脑室/代谢脑室/病理学疾病模型动物脑炎/微生物学脑炎/病理学免疫组织化学利斯特菌感染/代谢利斯特菌感染/病理学动物女(雌)性男(雄)性小鼠

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Successful treatment of ventriculitis due to carbapenem-resistant Acinetobacter baumannii with intraventricular colistin sulfomethate sodium

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CLINICAL INFECTIOUS DISEASES 1999年第4期28卷 916-917页

作者： Fernandez-Viladrich, P Corbella, X Corral, L Tuba, F Mateu, A Univ Barcelona Bellvitge Hosp Infect Dis Serv Dept Infect Dis Barcelona 08907 Spain Univ Barcelona Bellvitge Hosp Dept Intens Med Barcelona 08907 Spain Univ Barcelona Bellvitge Hosp Dept Microbiol Barcelona 08907 Spain

Presents a case of successful treatment of ventriculitis caused by carbapenem-resistant Acinetobacter baumannii with intraventricular colistin sulfomethate sodium. Description of the clinical characteristics of patien... 详细信息

关键词：不动杆菌属/药物作用不动杆菌感染/药物疗法不动杆菌感染/微生物学抗菌药/治疗应用脑疾病/药物疗法脑疾病/微生物学卡巴配能类/药理学中枢神经系统细菌感染/药物疗法中枢神经系统细菌感染/微生物学脑室/微生物学黏菌素/类似物和衍生物黏菌素/治疗应用抗药性微生物脑炎/药物疗法脑炎/微生物学注射脑室内治疗结果青少年成年人女(雌)性人类男(雄)性中年人

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VETERINARY RECORD 1999年第5期144卷 126-128页

作者： Piercy, DWT Griffiths, PC Teale, CJ Vet Labs Agcy Addlestone KT15 3NB Surrey England

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酷似结核性膜炎的单纯疱疹脑炎2例报告

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中风与神经疾病杂志 1994年第6期11卷 373页

作者：李敬阳刘群李蒂孙宏侠长春白求恩医科大学一院神经科

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VENTRICULAR INVOLVEMENT IN EXPERIMENTAL HEMOPHILUS-INFLUENZAE MENINGITIS

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JOURNAL OF PEDIATRICS 1978年第6期93卷 927-930页

作者： DAUM, RS SCHEIFELE, DW SYRIOPOULOU, VP AVERILL, D SMITH, AL CHILDRENS HOSP MED CTR DEPT PEDIAT DIV INFECT DIS BOSTON MA 02115 USA CHILDRENS HOSP MED CTR DEPT NEUROPATHOL BOSTON MA 02115 USA

The frequency of ventricular involvement during H. influenzae (HIB) type b meningitis in 10 bacteremic infant rhesus monkeys was determined. Meningitis was defined as CSF obtained from the lumbar subarachnoid space or cisterna magna containing bacteria and 10 or more leukocytes/mm3. HIB were cultured from 22 of 22 ventricular CSF samples. In 17 of 18 comparisons of bacterial density in ventricular and cisternal CSF, the values were within 1 log10;similarly, 5 of 8 quantitative ventricular-lumbar comparisons were within 1 log10. This concordance was present at bacterial densities of 2 .times. 101 to 1 .times. 109 CFU[colony forming units]/ml. When discordance was present, the ventricular CSF contained more bacteria. In 15 of 20 comparisons of leukocyte density in ventricular and cisternal CSF, the ventricular pleocytosis was lower (mean ventricular/cisternal ratio 0.08) Infection of the lateral cerebral ventricle is a uniform feature of HIB meningitis in infant monkeys, but the cellular inflammatory component is less.

关键词：脑室/微生物学脑室/病理学脑脊髓液/细胞学脑炎/脑脊髓液脑炎/微生物学脑炎/病理学嗜血菌流感类人猿亚目炎症白细胞/病理学恒河猴脑膜炎嗜血杆菌性/并发症动物女(雌)性男(雄)性

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