A young woman presented with a 2 yr history of a severe bleeding disorder and marked deficiencies in all 4 vitamin-K-dependent factors. Metabolic studies with tracer doses of 3H-vitamin K1 suggested that the patient m...
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A young woman presented with a 2 yr history of a severe bleeding disorder and marked deficiencies in all 4 vitamin-K-dependent factors. Metabolic studies with tracer doses of 3H-vitamin K1 suggested that the patient might be taking an oral anticoagulant;subsequently her plasma was found to contain a substance identical to phenindione in its spectrophotometric and chromatographic properties. The half-disappearance times of factors II, IX and X were measured after the administration of concentrate of these factors and were found to conform with published figures. The concentrate controlled the patient''s excessive bruising and prolonged skin and gingival bleeding. Factor VII may not be essential in reversal of the bleeding disorder induced by anticoagulant overdose.
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