目的观察微波针刺配合生血润肤饮治疗寻常型银屑病的临床疗效。方法将100例寻常型银屑病患者随机分为对照组和观察组,每组50例。对照组采用口服生血润肤饮加减治疗,观察组在对照组基础上加用微波针刺治疗。观察两组治疗前后各项中医症候(红斑、鳞屑、浸润增厚及皮损面积)积分、银屑病面积和严重程度指数(psoriasis area and severity index,PASI)评分、血清生物标志物[血管生成素2(angiopoietin 2,ANGPT2)、血管内皮生长因子受体3(vascular endothelial growth factor receptor-3,VEGFR-3)]水平及免疫功能各项指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))的变化情况,并比较两组临床疗效及不良反应发生率。结果观察组总有效率为96.0%,明显高于对照组的76.0%(P<0.05)。两组治疗后各项中医症候积分、PASI评分、CD8^(+)及血清ANGPT2、VEGFR-3水平均较同组治疗前显著下降,CD4^(+)、CD4^(+)/CD8^(+)均较同组治疗前显著上升,差异均具有统计学意义(P<0.05)。观察组治疗后各项中医症候积分、PASI评分、CD8^(+)及血清ANGPT2、VEGFR-3水平均明显低于对照组,CD4^(+)、CD4^(+)/CD8^(+)均明显高于对照组,差异均具有统计学意义(P<0.05)。对照组治疗期间不良反应发生率为4.0%,观察组为6.0%,两组比较差异无统计学意义(P>0.05)。结论微波针刺配合生血润肤饮是一种治疗寻常型银屑病的有效方法,能有效改善患者临床症状,降低血清ANGPT2及VEGFR-3水平,增强免疫功能,且安全可靠。
AIM: To explore if vascular endothelial growth factor receptor-3 (VEGFR-3) and carcinoembryonic antigen (CEA) can predict overall survival in advanced gastric ***: VEGFR-3 level was assessed by enzymelinked immunosorb...
详细信息
AIM: To explore if vascular endothelial growth factor receptor-3 (VEGFR-3) and carcinoembryonic antigen (CEA) can predict overall survival in advanced gastric ***: VEGFR-3 level was assessed by enzymelinked immunosorbent assay,and CEA was assessed by chemiluminescence immunoassay in the sera of 81 advanced gastric cancer patients before treatment with oxaliplatin plus 5-fluorouracil and folinic ***: Median survival time in patients with a low serum VEGFR-3 level was significantly longer than in those with a higher VEGFR-3 level (15.4 mo vs 7.7 mo,P < 0.001).Patients with a low CEA level had a longer survival than those with a higher CEA level (15.8 mo vs 8.6 mo,P < 0.001).Thirty-nine patients with low VEGFR-3 and low CEA levels had a median survival of 19.7 mo (P = 0.0006).The hazard ratio for patients with a high VEGFR-3 level was 2.443 (P = 0.002).CONCLUSION: High serum VEGFR-3 level is correlated significantly with poor *** patients with a high serum level of VEGFR-3,alternative chemotherapy regimens should be considered.
暂无评论