检索结果-内蒙古大学图书馆

Intracellular calcium signalling in magnocellular neurones of the rat supraoptic nucleus: understanding the autoregulatory mechanisms

引用

EXPERIMENTAL PHYSIOLOGY 2000年第Sup1期85卷 75S-84S页

作者： Dayanithi, G Sabatier, N Widmer, H CNRS UPR 9055 F-34094 Montpellier 5 France INSERM U469 CCIPE F-34094 Montpellier 5 France

Oxytocin and vasopressin, released at the soma and dendrites of neurones, bind to specific autoreceptors and induce an increase in [Ca2+](i). In oxytocin cells, the increase results from a mobilisation of Ca2+ from intracellular stores, whereas in vasopressin cells, it results mainly from an influx of Ca2+ through voltage-dependent channels. The response to vasopressin is coupled to phospholipase C and adenylyl-cyclase pathways which are activated by V-1 (V-1a and V-1b)- and V-2-type receptors respectively. Measurements of [Ca2+](i) in response to V-1a and V-2 agonists and antagonists suggest the functional expression of these two types of receptors in vasopressin neurones. The intracellular mechanisms involved are similar to those observed for the action of the pituitary adenylyl-cyclase-activating peptide (PACAP). Isolated vasopressin neurones exhibit spontaneous [Ca2+](i) oscillations and these are synchronised with phasic bursts of electrical activity. Vasopressin modulates these spontaneous [Ca2+](i) oscillations in a manner that depends on the initial state of the neurone, and such varied effects of vasopressin may be related to those observed on the electrical activity of vasopressin neurones in vivo.

关键词：钙信号/生理学内环境稳定/生理学神经元/生理学催产素/生理学视上核/细胞学视上核/生理学血管升压素类/生理学动物大鼠

来源：评论

学校读者我要写书评

暂无评论

Diurnal rhythms in neurohypophysial function

引用

EXPERIMENTAL PHYSIOLOGY 2000年第Sup1期85卷 179S-186S页

作者： Forsling, ML Guys Kings & St Thomas Sch Med Neuroendocrine Labs London SE1 9RT England

The neurohypophysial hormones oxytocin and vasopressin show daily rhythms of secretion with elevated hormone release during the hours of sleep. This pattern can be modulated by ovarian steroids and alters with age. The pattern appears to be due in part to the nocturnal increase in melatonin secretion, which stimulates hormone release in man, while being inhibitory in the rat. Pinealectomy alters both the 24 h pattern of neurohypophysial hormone release in the rat and the firing rate of magnocellular supraoptic nucleus neurones. There is also a reduced hormone release in response to hypovolaemia and raised plasma sodium concentration compared to sham operated animals, with a smaller increase in neuronal activity. as determined by immediate-early gene expression. The normal responses can be restored by nocturnal administration of melatonin. Melatonin also influences the neurohypophysial hormone response in the human to known stimuli of release, such as raised plasma osmolality, exercise and insulin-induced hypoglycaemia. Recent studies have revealed that not only does the release of vasopressin and oxytocin vary over each 24 h, but the respective renal and pregnant uterine responses also show diurnal variations.

关键词：昼夜节律/生理学催产素/生理学垂体后叶/生理学血管升压素类/生理学动物人类

来源：评论

学校读者我要写书评

暂无评论

Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: Study in vasopressin-deficient Brattleboro rats

引用

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1999年第18期96卷 10397-10402页

作者： Bardoux, P Martin, H Ahloulay, M Schmitt, F Bouby, N Trinh-Trang-Tan, MM Bankir, L INSERM U367 F-75005 Paris France Hop Necker Enfants Malad U90 INSERM F-75743 Paris 15 France Hop Necker Enfants Malad Biochim Lab A F-75743 Paris 15 France

Diabetic nephropathy represents a major complication of diabetes mellitus (DM), and the origin of this complication is poorly understood. Vasopressin (VP), which is elevated in type I and type II DM, has been shown to increase glomerular filtration rate in normal rats and to contribute to progression of chronic renal failure in 5/6 nephrectomized rats, The present study was thus designed to evaluate whether VP contributes to the renal disorders of DM, Renal function was compared in Brattleboro rats with diabetes insipidus (DI) lacking VP and in normal Long-Evans (LE) rats, with or without streptozotocin-induced DM, Blood and urine were collected after 2 and 4 weeks of DM, and creatinine clearance, urinary glucose and albumin excretion, and kidney weight were measured. Plasma glucose increased 3-fold in DM rats of both strains, but glucose excretion was approximate to 40% lower in DI-DM than in LE-DM, suggesting less intense metabolic disorders, Creatinine clearance increased significantly in LE-DM (P < 0.01) but failed to increase in DI-DM, Urinary albumin excretion more than doubled in LE-DM but rose by only 34% in DI-DM rats (P < 0.05), Kidney hypertrophy was also less intense in DI-DM than in LE-DM (P < 0.001), These results suggest that VP plays a critical role in diabetic hyperfiltration and albuminuria induced by DM, This hormone thus seems to be an additional risk factor for diabetic nephropathy and, thus, a potential target for prevention and/or therapeutic intervention.

关键词：白蛋白尿肌酸酐/代谢尿崩症/遗传学尿崩症/病理生理学糖尿病实验性/病理生理学糖尿病肾病/病理生理学肾小球滤过率糖尿肥大肾/病理学肾/病理生理学肾功能衰竭慢性/病理生理学肾切除术器官测量大鼠 Brattleboro 大鼠 Long-Evans 血管升压素类/缺乏血管升压素类/遗传学血管升压素类/生理学动物男(雄)性大鼠

来源：评论

学校读者我要写书评

暂无评论

Physiological pathways regulating the activity of magnocellular neurosecretory cells

引用

PROGRESS IN NEUROBIOLOGY 1999年第6期57卷 625-655页

作者： Leng, G Brown, CH Russell, JA Univ Edinburgh Sch Med Dept Physiol Neuroendocrinol Lab Edinburgh EH8 9AG Midlothian Scotland

Magnocellular oxytocin and vasopressin cells are among the most extensively studied neurons in the brain: their large size and high synthetic capacity, their discrete, homogeneous distribution and the anatomical separation of their terminals from their cell bodies, and the ability to determine their neuronal output readily by measurements of hormone concentration in the plasma, combine to make these systems amenable to a wide range of fundamental investigations While vasopressin cells have intrinsic burst-generating properties, oxytocin cells are organized within local pattern-generating networks. In this review we consider the role played by particular different pathways in the regulation of the activity of oxytocin and vasopressin cells. For both cell types, the effects of changes in the activity of synaptic input can be complex. (C) 1999 Elsevier Science Ltd. All rights reserved.

关键词：传入通路/药物作用传入通路/生理学心血管生理学细胞大小胆囊收缩素/药理学神经分泌系统/药物作用神经分泌系统/生理学催产素/生理学血管升压素类/生理学水电解质平衡动物女(雌)性人类妊娠

来源：评论

学校读者我要写书评

暂无评论

RENAL-FUNCTION AND DIURETIC THERAPY IN INFANTS AND CHILDREN .1.

引用

JOURNAL OF PEDIATRICS 1975年第4期86卷 485-496页

作者： LOGGIE, JMH KLEINMAN, LI VANMAANEN, EF UNIV CINCINNATI COLL MED DEPT ENVIRONM HLTH CINCINNATI OH USA CHILDRENS HOSP RES FDN DIV CLIN PHARMACOL ELLAND AVE CINCINNATI OH 45229 USA UNIV CINCINNATI COLL MED DEPT PHYSIOL CINCINNATI OH USA UNIV CINCINNATI COLL MED DEPT PHARMACOL & THERAPEUTICS CINCINNATI OH USA

来源：评论

学校读者我要写书评

暂无评论

ELECTROPHYSIOLOGY OF OXYTOCIN ACTIONS ON CENTRAL NEURONS

引用

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES 1992年第1期652卷 46-57页

作者： DREIFUSS, JJ DUBOISDAUPHIN, M WIDMER, H RAGGENBASS, M UNIV GENEVA MED CTR DEPT PHYSIOL CH-1211 GENEVA 4 SWITZERLAND

The action of oxytocin on neurons located in the dorsal motor nucleus of the vagus nerve was studied in brain slices in vitro. It acted postsynaptically and caused a reversible, concentration-dependent excitation of vagal motoneurons in rats. This effect is specific, since it could be mimicked by a selective agonist and suppressed by an oxytocin antagonist. Single-electrode voltage-clamp recordings from rat vagal motoneurons indicated that oxytocin generates a noninactivating inward current, whose amplitude increased as the membrane was depolarized. This current was insensitive to TTX, to a reduction of membrane calcium currents, and to a reversal in the transmembrane chloride gradient; and it was unaffected by several potassium channel blockers. By contrast, it was reversibly reduced by partially substituting extracellular sodium with equimolar N-methyl-D-glucamine. These results suggest that oxytocin exerts its neuronal action in the rat brainstem by generating a sustained voltage-dependent sodium current. Vasopressin activates a similar current when acting on motoneurons located in the facial nucleus of newborn rats. These fast, neurotransmitter-like actions of oxytocin and of vasopressin may provide an explanation--though not necessarily the sole explanation--for their central effects on maternal, sexual, and social behaviors.

关键词：电生理学催产素/生理学突触传递/生理学迷走神经/生理学血管升压素类/生理学动物男(雄)性大鼠

来源：评论

学校读者我要写书评

暂无评论

THE EFFECT OF NUTRITIONAL DEFICIENCY ON THE PITRESSIN INACTIVATING ABILITY OF THE LIVER

引用

AMERICAN JOURNAL OF CLINICAL NUTRITION 1956年第1期4卷 71-73页

作者： GUGGENHEIM, K From the Laboratory of Nutrition Department of Biochemistry The Hebrew University-Hadassah Medical School Jerusalem Israel

来源：评论

学校读者我要写书评

暂无评论

Endogenous vasopressin modulates the cardiovascular responses to exercise

引用

NEUROPEPTIDES: STRUCTURE AND FUNCTION IN BIOLOGY AND BEHAVIOR 1999年第1期897卷 198-211页

作者： Michelini, LC Morris, M Univ Sao Paulo ICB Dept Fisiol & Biofis BR-05508900 Sao Paulo Brazil Wright State Univ Sch Med Dept Pharmacol & Toxicol Dayton OH 45401 USA

The role of brain-stem vasopressinergic projections in the genesis of reflex bradycardia and in the modulation of heart rate control during exercise is discussed on the basis of both changes in endogenous peptide content and heart rate changes observed during exercise. Dynamic running caused an increase in vasopressin content specifically in dorsal and ventral brain-stem areas. Rats pretreated Kith vasopressin or the V-1 receptor antagonist into the nucleus tractus solitarii (NTS) showed a significant potentiation or a marked blunting of the exercise tachycardia, respectively, without any change in the blood pressure response, It is proposed that long-descending vasopressinergic pathways from the hypothalamus to the NTS serves as one link between the two main neural controllers of the circulation, that is, the central command and feedback control mechanisms driven by the peripheral receptors signals. Therefore vasopressinergic input contributes to the adjustment of heart rate response (and cardiac output) to the circulatory demand during exercise.

关键词：血压脑/生理学心血管生理学现象/药物作用心率神经系统生理学现象强体力活动/生理学压力感受器/药物作用压力感受器/生理学血管升压素类/药理学血管升压素类/生理学动物人类大鼠

来源：评论

学校读者我要写书评

暂无评论

THE RADIOIMMUNOASSAY OF HUMAN NEUROPHYSINS: CONTRIBUTION TO THE UNDERSTANDING OF THE PHYSIOPATHOLOGY OF NEUROHYPOPHYSEAL FUNCTION

引用

Annals of the New York Academy of Sciences 1975年第1期248卷 281-303页

作者： Legros, Jean‐J. School of Medicine University of Liege Liège Belgium

来源：评论

学校读者我要写书评

暂无评论

MODULATION OF PASSIVE-AVOIDANCE BEHAVIOR OF RATS BY INTRACEREBROVENTRICULAR ADMINISTRATION OF ANTI-VASOPRESSIN SERUM

引用

BEHAVIORAL BIOLOGY 1976年第3期18卷 325-333页

作者： VANWIMERSMAGREIDANUS, TB DEWIED, D STATE UNIV UTRECHT FAC MEDRUDOLPH MAGNUS INST PHARMACOLUTRECHTNETHERLANDS

Intracerebroventricular administration of antivasopressin serum induces a severe disturbance in passive-avoidance behavior, due to an interference in memory processes by selective binding of vasopressin in the brain. Injection of antivasopressin serum immediately after the single learning trial induces almost complete inhibition of the passive-avoidance response when the animals were tested for retention 24 hr later. If injection of the antivasopressin serum is postponed for maximally 2 hr after the learning trial, the treatment still results in a marked disturbance in passive-avoidance behavior, indicating that storage processes involved in memory consolidation last for several hours. Moreover, administration of antivasopressin serum 1 hr prior to the retention session also results in passive-avoidance deficits. This suggests that vasopressin is also involved in retrieval processes.

关键词：遗忘逆行性/化学诱导回避学习/生理学脑/代谢剂量效应关系药物消退心理学/生理学免疫血清注射脑室内回忆/药物作用垂体肾上腺系统/生理学反应时间/药物作用记忆保持力(心理学)/药物作用时间因素血管升压素类/免疫学血管升压素类/代谢血管升压素类/生理学动物人类男(雄)性大鼠

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：