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DIFFERENTIAL EFFECTS OF VASOPRESSIN ON WATER, CALCIUM AND LYSOSOMAL ENZYME CONTENTS OF MITOCHONDRIA-RICH AND LYSOSOME-RICH (GRANULAR) EPITHELIAL-CELLS ISOLATED FROM BULLFROG URINARY-BLADDER

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MOLECULAR AND CELLULAR ENDOCRINOLOGY 1976年第2期4卷 89-106页

作者： PIETRAS, RJ NAUJOKAITIS, PJ SZEGO, CM UNIV CALIF DEPT BIOL LOS ANGELES CA 90024 USA UNIV CALIF MOLEC BIOL INST LOS ANGELES CA 90024 USA

Treatment of bullfrog urinary bladder with arginine vasopressin (AVP) elicited a dose-dependent increase in the basal movement of H2O and Na across isolated tissues. Epithelial cells from the mucosal surface and incubated with 10 mU [milliunits] AVP/ml for 30 min retained a greater amount of intracellular H2O and Ca than cells not treated th hormone. Epithelial cells were further separated into 2 major fractions by density gradient centrifugation;cells damaged during these manipulations were separated from viable cells and discarded. Morphological examination of the 2 respective fractions indicated that they largely consisted of mitochondria-rich (MR) and granular (G) cell types which line the lumen of bullfrog bladder. The Ca content of MR cells averaged 25% greater than that of G-type cells. G cells had a higher content of the characteristic lysosomal hydrolases, acid phosphatase and cathepsin B1 than that found in MR cells. Incubation of G cells with AVP elicited significant increments in H2O and Ca contents and extracellular release of lysosomal enzymes as compared to untreated cells. Among MR cells treated with AVP, Cell Ca declines slightly, but no significant increase in H2O content of extracellular hydrolase activity was detected in comparison with paired control cells. The physiological significance of acid proteinase release from G cells treated with AVP was evaluated in experiments with intact bladder. Proteinase inhibitors which suppress the activity of cathepsin B1 selectively antagonized the action of hormone on H2O permeation. Alterations in the Ca and lysosomal hydrolase activity associated with G cells exposed to AVP may contribute to the hormone-induced H2O flow observed across the intact epithelium.

关键词：酸性磷酸酶/代谢无尾目精氨酸加压素/药理学身体水份/代谢钙/代谢组织蛋白酶类/代谢细胞质颗粒/代谢细胞质颗粒/超微结构上皮细胞上皮/药物作用上皮/代谢上皮/超微结构溶酶体/药物作用溶酶体/代谢显微镜检查电子线粒体/药物作用线粒体/代谢线粒体/超微结构牛蛙膀胱/药物作用膀胱/代谢血管升压素类/类似物和衍生物动物

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PLASMA ARGININE VASOPRESSIN IN SYNDROME OF ANTIDIURETIC-HORMONE EXCESS ASSOCIATED WITH BRONCHOGENIC CARCINOMA

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AMERICAN JOURNAL OF MEDICINE 1976年第6期61卷 825-831页

作者： PADFIELD, PL MORTON, JJ BROWN, JJ LEVER, AF ROBERTSON, JIS WOOD, M FOX, R WESTERN INFIRM MRC BLOOD PRESSURE UNIT GLASGOW G116NT SCOTLAND

A study of plasma arginine vasopressin in 17 patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) associated with bronchogenic carcinoma, revealed that the arginine vasopressin levels were elevated in most. In 14 patients with bronchogenic carcinoma, but without overt SIADH, plasma levels of arginine vasopressin were significantly higher than in normal subjects (P < 0.001). This, together with the finding of a lower than normal plasma osmolality in this group, suggests that inappropriate ADH excess might be more common in patients with bronchogenic carcinoma than previously thought. The normal positive correlation between plasma osmolality and plasma arginine vasopressin was reversed in SIADH. Seven of 9 patients with overt SIADH, studied after fluid deprivation, showed an increase in plasma arginine vasopressin coincident with an increase in plasma osmolality (r = +0.8, P < 0.01). In 1 patient, plasma arginine vasopressin returned to the original level following rehydration. The possibility that this might imply a degree of physiologic control to what is generally considered an autonomous secretion is discussed. It is considered more likely that other factors, including changes in plasma volume and glomerular filtration, might explain the increase in plasma levels of arginine vasopressin.

关键词：精氨酸加压素/血液癌支气管原/血液癌支气管原/并发症低钠血症/并发症肺肿瘤/血液肺肿瘤/并发症容积渗克分子浓度综合征血管升压素类/类似物和衍生物血管升压素类/血液禁水成年人老年人女(雌)性人类男(雄)性中年人

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CHANGES IN URINARY WATER AND ELECTROLYTE EXCRETION IN SODIUM-LOADED SHEEP IN RESPONSE TO INTRAVENOUS-INFUSION OF ARGININE VASOPRESSIN

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QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES 1976年第1期61卷 57-70页

作者： SCOTT, D MORTON, JJ ROWETT RES INST ABERDEEN SCOTLAND WESTERN INFIRM MRC BLOOD PRESSURE UNIT GLASGOW SCOTLAND

Mature sheep receiving supplements of sodium chloride into the rumen were given intravenous infusions of arginine vasopressin at rates varying from 4-6-23 pmol/min (2-10 mU/min). Infusion of the hormone led to an increase in urine flow and to increases in the amounts of sodium and chloride excreted, the effect on flow was, however, the greater so that the osmolality of the urine fell during the infusions. In sheep given intravenous infusions of a hypertonic sodium chloride solution addition of vasopressin to the infusate led to the formation of a larger volume of urine containing a higher proportion of the infused salt load compared to when the salt solution alone was given. As before the effect on flow was the greater and hence the osmolality of the urine was lower when the hormone was given. In other experiments intravenous infusion of a hypertonic sodium chloride solution at rates providing 2-8 mmol NaCl/min led to increases in urine flow and increases in sodium and chloride excretion, the size of these increases being proportional to infusion rate. Plasma vasopressin levels markedly increased during these infusions, the levels seen being similar to those seen in sheep given vasopressin in amounts which increased both urine flow and electrolyte excretion. This suggests that during hypertonic salt loading vasopressin probably contributes directly to the increases in urine flow and the increases in electrolyte excretion which are seen. Further evidence in support of this was obtained in experiments in which a greater natriuretic response was seen in sheep given a hypertonic sodium chloride solution into the carotid artery as opposed to the given a hypertonic sodium chloride solution into the carotid artery as opposed to the jugular vein and where it was shown that plasma vasopressin levels were indeed higher when the solution was given into the artery.

关键词：血管紧张素Ⅱ/血液精氨酸加压素/血液精氨酸加压素/药理学血压/药物作用氯化物/尿利尿/药物作用电解质/血液电解质/尿肾小球滤过率/药物作用注射动脉内注射静脉内钠尿增多/药物作用容积渗克分子浓度盐水高渗/投药和剂量盐水高渗/药理学绵羊钠/血液血管升压素类/类似物和衍生物水/药理学动物女(雌)性

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PROLYL-LEUCYL-GLYCINAMIDE (PLG) FACILITATES MORPHINE-DEPENDENCE

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LIFE SCIENCES 1976年第9期19卷 1331-1339页

作者： VANREE, JM DEWIED, D STATE UNIV UTRECHT FAC MED RUDOLF MAGNUS INST PHARMACOL UTRECHT NETHERLANDS

The development of physical dependence to morphine is facilitated in rats treated with [desglycinamide (9), arginine (8)] -vasopressin (DG-AVP) or with oxytocin. Oxytocin appeared to be more potent than DG-AVP. The essential elements of vasopressin and oxytocin required for facilitating morphine tolerance and physical dependence, are located in the C-terminal part of these hormones. It was found that the C-terminal tripeptide of oxytocin, prolylleucyl-glycinamide, was the most potent oligopeptide in this respect.

关键词：镇痛精氨酸加压素/类似物和衍生物精氨酸加压素/药理学体温/药物作用体重/药物作用药物协同作用吗啡依赖纳洛酮/药理学寡肽类/药理学催产素/药理学构效关系血管升压素类/类似物和衍生物动物女(雌)性人类大鼠

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EFFECTS OF VASOPRESSIN IN EXPERIMENTAL NEPHROANGIOGRAPHY

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ACTA RADIOLOGICA-DIAGNOSIS 1975年第6期16卷 609-617页

作者： GOTHLIN, J SAKUMA, S ISHIGAKI, T UNIV HOSP LUND DEPT DIAG RADIOL S-221 85 LUND SWEDEN NAGOYA UNIV MED SCH DEPT RADIOL NAGOYA JAPAN

Nephroangiography was performed in 13 rabbits using eight-fold magnification with a 0.05 mm focus. After arginine vasopressin in doses of 0.01 to 1.0 IU the glomeruli were well demonstrated as well as the subcortial arteries and veins and the concentration of contrast medium in arteries and veins increased. At increasing doses of vasopressin the glomeruli were shut off to an increasing degree, beginning at the outer part of the cortex. At 1.0 IU only the juxtamedullary glomeruli functioned.

关键词：精氨酸加压素/投药和剂量精氨酸加压素/药理学抑制化学性剂量效应关系药物注射动脉内肾小球旁器/药物作用肾小球旁器/放射摄影术肾/放射摄影术肾小球/药物作用肾小球/放射摄影术 X线影像增强肾动脉/放射摄影术肾静脉/放射摄影术血管阻力/药物作用血管升压素类/类似物和衍生物动物兔

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SOME PROPERTIES OF NEUROPHYSINS ISOLATED FROM BOVINE NEUROSECRETORY GRANULES

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1975年第FEB21期248卷 235-245页

作者： PLISKA, V MEYERGRASS, M SWISS FED INST TECHNOL INST MOLEC BIOL & BIOPHYS8049 ZURICHSWITZERLAND

Our experiments with the neurophysin-related proteins from bovine NSG have demonstrated that these species differ in several important respects from the materials conventionally prepared. (1) In structural terms, the NSG proteins are essentially identical with the conventional neurophysins in amino acid composition and closely similar in immunoreactivity; however, the presence of carbodydrate and lipid moieties in the NSG material, no matter how they are attached, constitutes a structural difference apparently sufficient to cause considerable changes in properties. (2) The affinities for the neurohypophyseal hormones of the NSG proteins are very much higher than those of the 'conventional' neurophysins and, moreover, the binding properties of the NSG material are much more stable with time under the conditions of the binding experiments. (3) The low binding capacities of the NSG materials, even when they are purified to apparent molecular homogeneity, indicate a functional heterogeneity perhaps related to supramolecular structure. (4) The conversion of the NSG proteins by acid or alkali treatment to materials resembling the 'conventional' neurophysins in their binding properties suggests that the latter may be isolation artifacts. Although we cannot as yet consistently explain the properties of our neurophysins from NSG, we offer the hypothesis that the low binding capacity, as also the Hill coefficient greater than 1 (cf. Reference 25) are indicative of molecular aggregation, perhaps mediated or facilitated by the nonprotein components. It is conceivable that such aggregation, proceeding in the more 'natural' environment of the NSG in a more precisely organized manner, might constitute the truly 'native,' fully functional state of the neurophysins. In this context it is of interest to record our preliminary observations, which suggest the presence of a protein of 10,000 mol. wt. in the NSG membrane fraction (SDS gel) as well as electron-microscopic indications30 of

关键词：氨基酸类/分析结合部位交叉反应细胞质颗粒/分析电泳聚丙烯酰氨凝胶等电聚焦赖氨酸后叶激素运载蛋白类/分离和提纯垂体后叶/分析蛋白质结合蛋白质构象溶解度血管升压素类/类似物和衍生物动物牛

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HYDRO-OSMOTIC ACTIVITY OF CARBA ANALOGUES OF OXYTOCIN AND [8-ARGININE] VASOPRESSIN ON FROG (RANA-ESCULENTA) BLADDER

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EUROPEAN JOURNAL OF PHARMACOLOGY 1975年第2期32卷 214-220页

作者： BARTH, T LEBARS, NC ROY, C JARD, S CZECHOSLOVAK ACAD SCI INST ORG CHEM & BIOCHEM PRAGUE 6 CZECHOSLOVAKIA COLL FRANCE LAB PHYSIOL CELLULAIRE 75231 PARIS FRANCE

The biological potency of neurohypophysial hormone analogues in stimulating water transport across the frog bladder (Rana esculenta) was estimated from the pD2 (negative logarithm of the peptide concentration eliciting 50% of its maximal hydroosmotic effect) and from the maximal response. Most analogues elicited maximal responses similar to those of the natural hormones. Both replacement of sulfur by a methylene group in the disulfide bridge and omission of the terminal amino group in oxytocin reduced hydroosmotic activity; carba substitution in oxytocin led to a greater drop in pD2 than the same substitution in deamino-oxytocin. On the contrary, the effects of substituting phenylalanine for tyrosine and of omitting the amino group were almost additive. Elimination of the carboxyl-terminal tripeptide sequence considerably reduced hydroosmotic potency; pressinamide was inactive up to 3 mug/ml. The highly potent antidiuretic peptides, deamino-[D-Arg8]vasopressin and deamino-6-carba-]D-Arg8]vasopressin, were weakly active in the hydroosmotic assay.

关键词：氨基酸序列精氨酸加压素/类似物和衍生物精氨酸加压素/药理学细胞膜通透性/药物作用催产素/类似物和衍生物催产素/药理学肽链终止翻译食用蛙膀胱/药物作用血管升压素类/类似物和衍生物动物

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