作者：
Basu, SEriksson, MUppsala Univ
Fac Med Dept Geriatr Clin Nutr Res SE-75125 Uppsala Sweden Uppsala Univ
Fac Med Dept Anaesthesiol & Intens Care SE-75125 Uppsala Sweden
Lipid peroxidation and antioxidant balance in the body is a crucial factor in the pathophysiology of various diseases. This study investigates the circulatory alpha-tocopherol levels and its relationship with 8-iso-pr...
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Lipid peroxidation and antioxidant balance in the body is a crucial factor in the pathophysiology of various diseases. This study investigates the circulatory alpha-tocopherol levels and its relationship with 8-iso-prostaglandin F(2 alpha) (8-iso-PGF(2 alpha)), a non-enzymatic and, 15-keto-13,14-dihydro-PGF(2 alpha) (15-K-DH-PGF(2 alpha)), a cyclooxygenase catalysed oxidation product of arachidonic acid in experimental septic shock in pigs. A steady decrease in alpha-tocopherol levels in plasma was observed in both survivor and non-survivor animals. A simultaneous increase of oxidative injury indicator, plasma 8-iso-PGF(2 alpha) was seen in both groups but with a different fashion. 8-Iso-PGF(2 alpha) levels increased steadily in the animals that died during the experiment. An early and rapid increase of plasma 15-K-DH-PGF(2 alpha), an inflammatory response indicator, was also observed in all animals. There was a significant difference in the kinetics of decrement of cx-tocopherol levels and a concomitant increase in 15-K-DH-PGF(2 alpha) levels among the non-survivors. Thus, a successive disappearance of circulatory vitamin E in conjunction with the surge of plasma isoprostanes and prostaglandins impairs the oxidant-antioxidant balance in favour of the former and may possibly have an effect on the survivality during experimental porcine septicaemia. (C) 2000 Harcourt Publishers Ltd.
Prognosis in Takayasu's arteritis is limited owing to renovascular hypertension. The authors report a patient with Takayasu's arteritis,who had been unilaterally nephrectomized and presented with malignant hyp...
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Prognosis in Takayasu's arteritis is limited owing to renovascular hypertension. The authors report a patient with Takayasu's arteritis,who had been unilaterally nephrectomized and presented with malignant hypertension due to renal artery stenosis. Hypertension was refractory to conventional antihypertensive treatment, and stenosis was not accessible by interventional angioplasty. Initiation of enalapril and losartan therapy was successful in improving blood pressure without deterioration of renal function due to ischemic failure. Antihypertensive treatment resulted in dramatically stimulated endogenous nitric oxide (NO) synthesis, while elevated plasma endothelin-l levels were unchanged. Renovascular hypertension in Takayasu's arteritis is associated with an imbalance of vasoconstrictor peptide endothelin-l and vasodilator peptide NO. Successful treatment of hypertension by enalapril or losartan results in improved endogenous NO synthesis, which putatively counterbalances excessive vasoconstrictor actions and may retard the progression of renal failure.
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