An abnormal pulmonary vasculature has been reported as an important component of bronchopulmonary dysplasia (BPD).We tested the hypothesis of an early abnormal vascular network pattern in infants with *** infants with...
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An abnormal pulmonary vasculature has been reported as an important component of bronchopulmonary dysplasia (BPD).We tested the hypothesis of an early abnormal vascular network pattern in infants with *** infants with BPD (nine boys and six girls; gestational age 27.5 ±2.0 wk; birth weight 850 ±125 g) and 15 sex-and gestational age-matched infants (nine boys and six girls; gestational age 27.6 ±2.6 wk; birth weight 865 ±135 g) were examined on postnatal days 1 and *** infants showed a significantly higher prevalence of histologic chorioamnionitis (p = 0.009), as well as higher intubation duration (p = 0.0004), oxygen supplementation (p < 0.0001), and initial illness severity (p = 0.0002) than the BPD-negative *** lower gingival and vestibular oral mucosa was chosen as the study *** blood vessel areawas determined, and the oral vascular networks were characterized by analyzing their complexity (D, at two scales: D 1-46, D 1-15), tortuosity (Dmin), and randomness (L-Z) of the vascular *** with BPD showed a significantly lower blood vessel area aswell as a higher vascular network complexity (D 1-46, D 1-15, and L-Z) than control subjects (p < 0.0001).Our findings provide a new early clinical sign in BPD and stress the importance of an early disorder in the oral mucosal vascularization process in the disease pathogenesis.
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