检索结果-内蒙古大学图书馆

作者：段淑芳福建中医学院

学位级别：硕士

背景:糖尿病血管病变与胰岛素抵抗所致的高血糖、高血压、高血脂、高血粘等众多因素导致的动脉粥样硬化有关,而在众多因素中脂代谢紊乱起着更为重要的作用。目的:本实验观察糖尿病中医证型与脂代谢紊乱、脑梗死的关系,为以后在中西... 详细信息

背景:糖尿病血管病变与胰岛素抵抗所致的高血糖、高血压、高血脂、高血粘等众多因素导致的动脉粥样硬化有关,而在众多因素中脂代谢紊乱起着更为重要的作用。目的:本实验观察糖尿病中医证型与脂代谢紊乱、脑梗死的关系,为以后在中西医结合治疗糖尿病过程中及其血管并发症预防中起指导作用。资料与方法:按WHO诊断标准和中医辨证标准,选择122例2型糖尿病患者为研究对象,按中医证型分为5组。其中阴虚热盛型23例、女11,男12,合并脑梗5例;气阴两虚型37例、女21,男16,合并脑梗8例;阴阳两虚,血瘀水停11例、女9,男2,合并脑梗1例;湿热困脾型33例、女14,男19,合并脑梗17例;血瘀脉络型18例、女11,男7,合并脑梗10例。TC、TG、HDL用酶法,LDL=TC-HDL-TG/2.2（mmol/L）,HbA1C的测定采用微柱层析法。并对患者晨起血压进行测量。结果:1.在2型糖尿病患者5型之间年龄、血压不具有可比性的情况下:5型之间HbA1C比较结果:湿热困脾、血瘀脉络、气阴两虚>阴虚热盛、阴阳两虚。脑梗发病率显示:湿热困脾、血瘀脉络>气阴两虚、阴虚热盛、阴阳两虚。TC、TG、LDL 5型比较趋势:湿热困脾、血瘀脉络>气阴两虚、阴阳两虚>阴虚热盛。HDL 5型比较:湿热困脾、血瘀脉络<气阴两虚、阴虚热盛<阴阳两虚。***1C与TC、TG、LDL呈正相关（P<0.01）,与HDL呈负相关（P<0.05）,与脑梗死不具有相关性;TC、TG、LDL与脑梗死正相关（P<0.01）,HDL与脑梗死具有负相关（P<0.01）。结论:在糖尿病中医证型中湿热、血瘀越严重,则血糖控制越差、脂代谢紊乱越严重,合并脑梗死率的趋势越高。

关键词：糖尿病,非胰岛素依赖型/代谢脂蛋白类/代谢血管疾病/病因学脑梗塞/病因学湿热/代谢血瘀/代谢血糖

来源：评论

学校读者我要写书评

暂无评论

血清抵抗素水平与2型糖尿病患者血管并发症的相关性研究

引用

陕西医学杂志 2008年第3期37卷 312-313页

作者：圈启芳薛海波李肃徐希坤卢承德青海大学附属医院内分泌科西宁810001 青海大学医学院

目的:探讨血清抵抗素水平与2型糖尿病(T2DM)患者血管并发症的关系,及其可能在T2DM血管并发症中所起的作用。方法:选取40例T2DM患者,同时选取20例健康人作为对照组。受试者空腹采血,测定血清抵抗素、一氧化氮(NO)、血管性血友病因子(vWF)... 详细信息

目的:探讨血清抵抗素水平与2型糖尿病(T2DM)患者血管并发症的关系,及其可能在T2DM血管并发症中所起的作用。方法:选取40例T2DM患者,同时选取20例健康人作为对照组。受试者空腹采血,测定血清抵抗素、一氧化氮(NO)、血管性血友病因子(vWF);行OGTT并测定C肽、胰岛素及生化检查,同时测血压、身高、体重、腰围、体重指数、胰岛素敏感指数、胰岛素抵抗指数等。结果:T2DM患者血清抵抗素、vWF水平均高于正常对照组;NO低于正常对照组。T2DM组抵抗素与vWF呈正相关;与NO呈负相关。结论:T2DM患者血清抵抗素水平增高,且与血管内皮功能相关指标呈正或负相关,提示抵抗素可能与T2DM血管并发症的发生有关,是预测血管并发症的有价值的指标。

关键词：糖尿病非胰岛素依赖型/并发症 @抵抗素血管疾病/病因学内皮血管

来源：评论

学校读者我要写书评

暂无评论

C肽、血脂水平与2型糖尿病下肢血管病变的关系

引用

陕西医学杂志 2006年第3期35卷 316-318页

作者：鲍缦夕邹大进武警海南总队医院内科 570203 第二军医大学长海医院内分泌科

目的探讨2型糖尿病患者下肢血管病变的危险因素。方法应用美国GE公司LOG-IQ700型超声诊断仪,对2型糖尿病患者131例下肢动脉进行检测,将下肢血管病变组74例与非下肢血管病变组54例进行对照,记录患者年龄、病程、空腹及餐后血糖、糖化血... 详细信息

目的探讨2型糖尿病患者下肢血管病变的危险因素。方法应用美国GE公司LOG-IQ700型超声诊断仪,对2型糖尿病患者131例下肢动脉进行检测,将下肢血管病变组74例与非下肢血管病变组54例进行对照,记录患者年龄、病程、空腹及餐后血糖、糖化血红蛋白、血脂、空腹及餐后C肽。结果糖尿病下肢血管病变组患者年龄大、病程长、LDL-C明显升高、空腹及餐后C肽明显降低。结论年龄、病程、高血糖、高血脂、低C肽水平是糖尿病下肢血管病变的危险因素,糖尿病神经病变与大血管病变正相关。

关键词：糖尿病非胰岛素依赖型/并发症血管疾病/病因学 C肽/分析血蛋白质腿类f分祆隧

来源：评论

学校读者我要写书评

暂无评论

Hypothermic circulatory arrest causes multisystem vascular endothelial dysfunction and apoptosis

引用

ANNALS OF THORACIC SURGERY 2000年第3期69卷 696-702页

作者： Cooper, WA Duarte, IG Thourani, VH Nakamura, M Wang, NP Brown, WM Gott, JP Vinten-Johansen, J Guyton, RA Emory Univ Crawford Long Hosp Carlyle Fraser Heart Ctr Cardiothorac Res Lab Atlanta GA 30365 USA Emory Univ Sch Med Atlanta GA 30365 USA

Background, Multiple organ failure after deep hypothermic circulatory arrest (DHCA) may occur secondary to endothelial dysfunction and apoptosis. We sought to determine if DHCA causes endothelial dysfunction and apoptosis in brain, kidney, lungs, and other tissues. Methods, Anesthetized pigs on cardiopulmonary bypass were: (1) cooled to 18 degrees C, and had their circulation arrested (60 minutes) and reperfused at 37 degrees C for 90 minutes (DHCA, n = 8);or (2) time-matched normothermic controls on bypass (CPB, n = 6). Endothelial function in cerebral, pulmonary, and renal vessels was assessed by vasorelaxation responses to endothelial-specific bradykinin (BK) or acetylcholine (ACh), and smooth muscle-specific nitroprusside. Results, In vivo transcranial vasorelaxation responses to ACh were similar between the two groups. In small-caliber cerebral arteries, endothelial relaxation (BK) was impaired in CPB vs DHCA (maximal 55% +/- 2% [p < 0.05] vs 100% +/- 6%). Pulmonary artery ACh responses were comparable between CPB (110% +/- 10%) and DHCA (83% +/- 6%), but responses in pulmonary vein were impaired in DI-ICA (109% +/- 3%, p < 0.05) relative to CPB (137% +/- 6%), In renal arteries, endothelial (ACh) responses were impaired in DHCA (71% +/- 13%) relative to CPB (129% +/- 14%), Apoptosis (DNA laddering) occurred primarily in duodenal tissue, with a greater frequency in DHCA (56%, p < 0.05) compared with normothermic CPB (17%) and nonbypass controls (0%), Conclusions, DHCA is associated with endothelial dysfunction in cerebral microvessels but not in the in vivo transcranial vasculature;in addition endothelial dysfunction was noted in large-caliber renal arteries and pulmonary veins. DHCA. is also associated with duodenal apoptosis. Vascular endothelial dysfunction and apoptosis may be involved in the pathophysiology of multisystem organ failure after DHCA, (C) 2000 by The Society of Thoracic Surgeons.

关键词：细胞凋亡脑/血液供给内皮血管/病理生理学肾/血液供给肺/血液供给猪血管疾病/病因学动物

来源：评论

学校读者我要写书评

暂无评论

Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever -: A possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy

引用

ARTHRITIS AND RHEUMATISM 1999年第5期42卷 1056-1061页

作者： Hayem, G Kassis, N Nicaise, P Bouvet, P Andremont, A Labarre, C Kahn, MF Meyer, O CHU Bichat Serv Rhumatol F-75877 Paris 18 France Inst Pasteur Paris France

We report a case of well-documented typhoid fever in a 30-year-old woman with inactive systemic lupus erythematosus with asymptomatic lupus anticoagulant and high-titer anticardiolipin antibody (aCL), Despite prompt eradication of the Salmonella typhi obtained,vith appropriate antibiotic therapy, multiple organ system dysfunction occurred, The central nervous system was involved, with ischemic infarcts in the occipital lobes. High-dose corticosteroid therapy failed to improve the neurologic manifestations, which responded to repeated plasmapheresis. A sharp fall in aCL and anti-beta(2)-glycoprotein I antibody titers was recorded before the start of plasmapheresis, At the same time, IgM and IgG antibodies to Salmonella group O:9 lipopolysaccharide became detectable;the IgM antibodies disappeared within 4 months, whereas the IgG antibodies remained detectable during the next 13 months, Despite treatment with high-dose corticosteroids and cyclophosphamide, rapidly progressive glomerulonephritis developed, leading to chronic renal failure, There is convincing evidence of a link between the S typhi infection and the ensuing catastrophic syndrome in this patient, probably precipitated by bacterial antigens.

关键词：抗磷脂综合征/并发症抗磷脂综合征/病因学血液凝固障碍/病因学脂多糖类/药理学红斑狼疮系统性/并发症红斑狼疮系统性/病因学沙门菌伤寒/免疫学伤寒/并发症血管疾病/病因学成年人女(雌)性人类

来源：评论

学校读者我要写书评

暂无评论

Long-term predictors of cognitive outcome in a cohort of older people with hypertension

引用

BRITISH JOURNAL OF PSYCHIATRY 2000年第1期177卷 66-71页

作者： Cervilla, JA Prince, M Joels, S Lovestone, S Mann, A Inst Psychiat London England Royal Free Hosp Dept Psychiat London NW3 2QG England

Background Deteriorating cognitive function in late life substantially increases the risk for dementia, for other non-cognitive morbidity, for dependency, and early death. Aims To identify early predictors of late-life cognitive outcome. Method Cognitive function, premorbid IQ, and cardiovascular risk exposure were recorded on 1083 subjects on entry to a hypertension treatment trial in 1983-1984. We followed up this cohort 9-12 years later to assess cognitive function with the Mini-Mental State Examination (MMSE), to update exposure status. and to obtain genomic material. Multivariate analysis was used to identify independent baseline predictors of cognitive outcome 9-12 years later. Results We followed up 387 subjects (58.6% of survivors). After adjusting for baseline cognition, poorer cognitive outcome was found to be independently associated with a family history of dementia, increasing age, less decline in systolic blood-pressure, lower premorbid IQ (rather than limited education), and abstinence from alcohol. Conclusions Reduction in systolic blood pressure (among hypertensives) and moderate alcohol intake could protect against cognitive deterioration in late life.

关键词：年龄分布方差分析消炎药非甾类/治疗应用认知障碍/病因学队列研究痴呆/遗传学痴呆/预防和控制高血压/心理学试验预期值危险因素血管疾病/病因学老年人女(雌)性人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

Hormone replacement therapy in postmenopausal women protects against smoking-induced changes in vascular structure and function

引用

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年第1期34卷 131-137页

作者： Teede, HJ Liang, YL Shiel, LM McNeil, JJ McGrath, BP Monash Med Ctr Dept Med Vasc Med Unit Clayton Vic 3168 Australia Monash Univ Alfred Hosp Dept Epidemiol & Prevent Med Melbourne Vic 3004 Australia

OBJECTIVES The purpose of this study was to investigate the role of hormone replacement therapy (HRT) in postmenopausal women who smoke. BACKGROUND Hormone replacement therapy appears to afford cardiovascular protection in postmenopausal women;however, in high risk individuals, specifically smokers, this has not been adequately studied. This question was addressed in a cross-sectional study of arterial structure, function and plasma lipids in postmenopausal smokers and nonsmokers. METHODS Vascular ultrasound was performed in two age-matched groups of postmenopausal women, 70 on HRT (35 smokers) and 70 control subjects not on HRT (35 smokers). Indexes of arterial structure (carotid intima-media thickness [IMT]) and vascular function (systemic arterial compliance [SAC]) and lipid profiles were measured. RESULTS Participant characteristics were similar in the two groups. Smokers on HRT, compared with smoking control subjects, had lower cholesterol(6.0 +/- 0.2 vs. 6.8 +/- 0.3 mmol/liter, p = 0.03) and more favorable mean values for IMT (0.64 +/- 0.02 vs. 0.74 +/- 0.03 mm, p = 0.007) and SAC (0.41 +/- 0.03 vs. 0.32 +/- 0.03 U/mm Hg, p = 0.03). Nonsmokers on HRT compared with nonsmoking control subjects had lower total cholesterol (5.7 +/- 0.2 vs. 6.5 +/- 0.2 mmol/liter, p = 0.02) and low density lipoprotein cholesterol (3.4 +/- 0.2 vs. 4.4 +/- 0.3 mmol/liter, p = 0.01). Mean IMT and SAC values in nonsmokers on HRT and control subjects were not significantly different. Multiple regression demonstrated significant correlation between HRT status and both IMT and SAC, in smokers and in those with increased cholesterol. In nonsmokers and those with lower cholesterol, HRT status was not significantly correlated with vascular parameters. CONCLUSIONS In postmenopausal women who smoke there may be a beneficial effect of long-term estrogen therapy on indexes of arterial structure and function as surrogate markers of cardiovascular disease. Long-term controlled studies are needed t

关键词：动脉/病理学动脉/病理生理学胆固醇 HDL/血液胆固醇 LDL/血液横断面研究雌激素替代疗法绝经后期/生理学吸烟/副作用吸烟/病理学吸烟/病理生理学甘油三酯类/血液血管内膜/病理学血管疾病/病因学血管疾病/病理学血管疾病/病理生理学血管疾病/预防和控制女(雌)性人类中年人

来源：评论

学校读者我要写书评

暂无评论

Endovascular stents in pediatric cardiovascular medicine

引用

JOURNAL OF INTERVENTIONAL CARDIOLOGY 1995年第6期8卷 767-775页

作者： Benson, LN Nykanen, D Freedom, RM DepartmentofPediatrics HospitalforSickChildrenUniversityofTorontoSchoolofMedicineOntarioCanada.

Acquired or de novo vascular obstructions can adversely affect the outcomes of management algorithms for children with congenital heart lesions. Although surgical repair is frequently feasible, some acquired or congenital obstructions are difficult to address in the operating theater. Discussed is the recent experience with endovascular stents To relieve such stenoses, and their impact on patient care.

关键词：动脉闭塞性疾病/病因学动脉闭塞性疾病/放射摄影术动脉闭塞性疾病/外科学心脏缺损先天性/并发症肺动脉/外科学肺静脉/放射摄影术肺静脉/外科学支架血管疾病/病因学血管疾病/放射摄影术血管疾病/外科学动物人类

来源：评论

学校读者我要写书评

暂无评论

The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration

引用

CELL 1999年第5期99卷 511-520页

作者： Streblow, DN Soderberg-Naucler, C Vieira, J Smith, P Wakabayashi, E Ruchti, F Mattison, K Altschuler, Y Nelson, JA Oregon Hlth & Sci Univ Dept Mol Microbiol & Immunol Portland OR 97201 USA Oregon Hlth & Sci Univ Vaccine & Gene Therapy Inst Portland OR 97201 USA Univ Washington Dept Lab Med Seattle WA 98195 USA Univ Washington Program Infect Dis Seattle WA 98104 USA Univ Calif San Francisco Sch Med Dept Anat San Francisco CA 94143 USA

Human cytomegalovirus (HCMV) infection of smooth muscle cells (SMCs) in vivo has been linked to a viral etiology of vascular disease. In this report, we demonstrate that HCMV infection of primary arterial SMCs results in significant cellular migration. Ablation of the chemokine receptor, US28, abrogates SMC migration, which is rescued only by expression of the viral homolog and not a cellular G protein-coupled receptor (GPCR). Expression of US28 in the presence of CC chemokines including RANTES or MCP-1 was sufficient to promote SMC migration by both chemokinesis and chemotaxis, which was inhibited by protein tyrosine kinase inhibitors. US28-mediated SMC migration provides a molecular basis for the correlative evidence that links HCMV to the acceleration of vascular disease.

关键词：血管/损伤细胞运动/生理学趋化因子CCL2/代谢炎症趋化因子类/代谢巨细胞病毒 GTP结合蛋白质类/代谢基因缺失模型生物学肌平滑血管/病毒学受体趋化因子/代谢信号传导血管疾病/病因学病毒蛋白质类/代谢人类

来源：评论

学校读者我要写书评

暂无评论

CLINICAL FEATURES OF IDIOPATHIC PRERETINAL MACULAR FIBROSIS - SCHOENBERG LECTURE

引用

AMERICAN JOURNAL OF OPHTHALMOLOGY 1975年第3期79卷 349-357页

作者： WISE, GN MONTEFIORE HOSP & MED CTR ALBERT EINSTEIN COLL MEDSAM GARTNER LIBDEPT OPHTHALMOL111 E 210THBRONXNY 10467

Of 150 consecutive cases of preretinal macular fibrosis that occurred predominantly in older subjects, 118 cases involved only one eye while 32 occurred binocularly. The ratio of women to men was 3:2. Visual acuity was usually 20/50 or better, and only 4 of 178 eyes had acuity below 20/200. The vast majority of lesions involved the macula and few extended outside the macular zone. The characteristic clinical finding on ophthalmoscopy was a glinting reflex probably due to a layer of connective tissue cells lying on the internal limiting membrane. Small white exudates, venous abnormalities, and occasional hemorrhages may also be preretinal of preretinal macular fibrosis. Amsler grid testing usually demonstrated irregularity and distortion of some part of the grid. Fluorescein angiography revealed a characteristic tortuosity of the small macular vessels. Most eyes had previous posterior vitreous detachments but except for one possible case, there were no cases where the posterior vitreous body was adherent to either the retinal membrane or the macular region. There was no significant systemic disease related to prerinatal macular fibrosis. In most instances, preretinal macular fibrosis either was stationary or slowly progressive. The etiology and treatment of the condition remains obscure.

关键词：动脉硬化/并发症糖尿病视网膜病变/诊断诊断鉴别水肿/诊断荧光素血管造影术荧光素类/诊断应用黄斑/血液供给黄斑变性/并发症检眼镜检查视网膜动脉视网膜脱离/诊断视网膜疾病/诊断视网膜疾病/流行病学视网膜疾病/病因学视网膜静脉血管疾病/病因学视敏度成年人老年人女(雌)性人类男(雄)性中年人

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：