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中华眼底病杂志 2016年第4期32卷 349-352页

作者：杜剑彤杨柳北京大学第一医院眼科视觉损伤与修复教育部重点实验室 100034

视网膜动脉缩窄、动静脉交叉压迫、微动脉瘤、视网膜出血、棉绒斑等视网膜血管异常表现与高血压等心血管疾病、糖尿病、脑卒中、肾病等全身血管疾病密切相关。充分利用现代眼底影像检查手段无创快捷、量化标准、智能分析等技术优势，全... 详细信息

视网膜动脉缩窄、动静脉交叉压迫、微动脉瘤、视网膜出血、棉绒斑等视网膜血管异常表现与高血压等心血管疾病、糖尿病、脑卒中、肾病等全身血管疾病密切相关。充分利用现代眼底影像检查手段无创快捷、量化标准、智能分析等技术优势，全面采集视网膜血管异常信息，深入探讨视网膜血管异常的形成转归机制以及与全身血管疾病之间的关系，不仅有助于进一步提升视网膜血管异常疾病的诊断治疗水平，而且还将有助于预测全身血管疾病的发生风险和干预效果。充分利用新的眼底影像检查技术，进一步加强视网膜血管异常与全身血管疾病的相关性研究，通过诊断视网膜血管疾病，为全身血管疾病的预防治疗提供证据；同时通过治疗全身血管疾病，为更好地治疗视网膜血管疾病提供基础。二者相辅相成，整体与局部互为促进，为患者带来更好的预后是未来医学发展的方向。

关键词：视网膜血管/损伤血管疾病/预防和控制体层摄影术光学相干述评

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血液透析内瘘术后血管并发症的外科处理及预防

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陕西医学杂志 2006年第3期35卷 292-293页

作者：罗云锋岳良升徐小平陈伟锋南方医科大学珠江医院普外科广州510282

目的：讨论血液透析内瘘术后血管并发症的外科处理及预防。方法：对血液透析内瘘术后3例U型人工血管造瘘感染并出血、2例腕部桡动静脉造瘘肢体缺血、3例腕部桡动静脉造瘘血栓形成并肱动脉瘤患者，分剐施行人工血管拆除、动脉端端吻合；... 详细信息

目的：讨论血液透析内瘘术后血管并发症的外科处理及预防。方法：对血液透析内瘘术后3例U型人工血管造瘘感染并出血、2例腕部桡动静脉造瘘肢体缺血、3例腕部桡动静脉造瘘血栓形成并肱动脉瘤患者，分剐施行人工血管拆除、动脉端端吻合；动静脉瘘口切除、桡动脉结扎；桡动脉吻合口切除取栓、动静脉端端吻合术。结果：随访5～23个月，平均12月，8例患者均无复发，其中动脉内瘘重建3例，血管吻合通畅。结论：血液透析内瘘术后血管并发症应早期处理，预防措施是关键。

关键词：肾透析/副作用血管疾病/预防和控制手术后并发症

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MANAGEMENT OF THE ARTERIAL PUNCTURE SITE

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JOURNAL OF INTERVENTIONAL CARDIOLOGY 1994年第2期7卷 187-193页

作者： SPOKOJNY, AM SANBORN, TA DivisionofCardiology DepartmentofMedicineNewYorkHospital-CornellUniversityMedicalCenter.

With more complex interventional procedures, such as intracoronary stent placement, there is a higher incidence of procedural related peripheral vascular complications including pseudoaneurysm and hemorrhage. In these procedures, the amount of anticoagulation as well as the use of thrombolytic agents intraprocedurally increases the risk of complication. Meticulous care during vascular access, careful use and monitoring of anticoagulation, and patient selection are helpful in reducing the risk. Newer vascular hemostatic devices utilizing biodegradable collagen plugs might be of advantage since they allow early sheath removal without interrupting anticoagulation and, therefore, early ambulation. However, it remains to be determined, whether these devices are effective in reducing complications, duration of bed rest and hospitalization, or improvement of stent patency. Newer designs, e.g., coated or biodegradable stents, or different deployment strategies might reduce the need of anticoagulation and lower the risk of peripheral vascular complications.

关键词：抗凝药/副作用胶原/治疗应用心脏导管插入术/副作用心脏导管插入术/方法出血/预防和控制止血技术/仪器和设备穿刺术/方法危险因素支架/副作用血管疾病/诊断血管疾病/预防和控制人类

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Hormone replacement therapy in postmenopausal women protects against smoking-induced changes in vascular structure and function

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 1999年第1期34卷 131-137页

作者： Teede, HJ Liang, YL Shiel, LM McNeil, JJ McGrath, BP Monash Med Ctr Dept Med Vasc Med Unit Clayton Vic 3168 Australia Monash Univ Alfred Hosp Dept Epidemiol & Prevent Med Melbourne Vic 3004 Australia

OBJECTIVES The purpose of this study was to investigate the role of hormone replacement therapy (HRT) in postmenopausal women who smoke. BACKGROUND Hormone replacement therapy appears to afford cardiovascular protection in postmenopausal women;however, in high risk individuals, specifically smokers, this has not been adequately studied. This question was addressed in a cross-sectional study of arterial structure, function and plasma lipids in postmenopausal smokers and nonsmokers. METHODS Vascular ultrasound was performed in two age-matched groups of postmenopausal women, 70 on HRT (35 smokers) and 70 control subjects not on HRT (35 smokers). Indexes of arterial structure (carotid intima-media thickness [IMT]) and vascular function (systemic arterial compliance [SAC]) and lipid profiles were measured. RESULTS Participant characteristics were similar in the two groups. Smokers on HRT, compared with smoking control subjects, had lower cholesterol(6.0 +/- 0.2 vs. 6.8 +/- 0.3 mmol/liter, p = 0.03) and more favorable mean values for IMT (0.64 +/- 0.02 vs. 0.74 +/- 0.03 mm, p = 0.007) and SAC (0.41 +/- 0.03 vs. 0.32 +/- 0.03 U/mm Hg, p = 0.03). Nonsmokers on HRT compared with nonsmoking control subjects had lower total cholesterol (5.7 +/- 0.2 vs. 6.5 +/- 0.2 mmol/liter, p = 0.02) and low density lipoprotein cholesterol (3.4 +/- 0.2 vs. 4.4 +/- 0.3 mmol/liter, p = 0.01). Mean IMT and SAC values in nonsmokers on HRT and control subjects were not significantly different. Multiple regression demonstrated significant correlation between HRT status and both IMT and SAC, in smokers and in those with increased cholesterol. In nonsmokers and those with lower cholesterol, HRT status was not significantly correlated with vascular parameters. CONCLUSIONS In postmenopausal women who smoke there may be a beneficial effect of long-term estrogen therapy on indexes of arterial structure and function as surrogate markers of cardiovascular disease. Long-term controlled studies are needed t

关键词：动脉/病理学动脉/病理生理学胆固醇 HDL/血液胆固醇 LDL/血液横断面研究雌激素替代疗法绝经后期/生理学吸烟/副作用吸烟/病理学吸烟/病理生理学甘油三酯类/血液血管内膜/病理学血管疾病/病因学血管疾病/病理学血管疾病/病理生理学血管疾病/预防和控制女(雌)性人类中年人

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Local paclitaxel delivery for the prevention of restenosis:: Biological effects and efficacy in vivo

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2000年第7期35卷 1969-1976页

作者： Herdeg, C Oberhoff, M Baumbach, A Blattner, A Axel, DI Schröder, S Heinle, H Karsch, KR Univ Tubingen Dept Med Div Cardiol D-72076 Tubingen Germany Univ Tubingen Dept Physiol D-72076 Tubingen Germany

OBJECTIVE The aim of this study was to evaluate the potential of paclitaxel to prevent restenosis in vivo. BACKGROUND Paclitaxel (Taxol) is a microtubule-stabilizing compound with potent antitumor activity. It influences the cytoskeleton equilibrium by increasing the assembly of altered microtubules, thereby inducing cellular modifications that result in reduced proliferation, migration and signal transduction. METHODS Before the in vivo study, delivery efficiency was determined with radiolabeled paclitaxel in porcine hearts. After induction of a defined plaque in the right carotid arteries of 76 New Zealand rabbits by electrical stimulation, 27 animals underwent balloon dilation and subsequent local paclitaxel delivery (10 ml, 10 mu mol/liter) with a double-balloon catheter. Twenty-nine animals served as control with angioplasty only, 10 animals underwent local delivery of vehicle only (0.9% NaCl solution) and 10 animals were solely electrostimulated. Vessels were excised one, four, and eight weeks after intervention. RESULTS The extent of stenosis in paclitaxel-treated animals was significantly reduced compared with balloon-dilated control animals (p = 0.0012, one, four and eight weeks after intervention: 14.6%, 24.6% and 20.5%, vs. 24.9%, 33.8% and 43.1%, respectively). Marked vessel enlargement compared with balloon-dilated control animals could be observed (p = 0.0001, total vessel area after one, four and eight weeks: paclitaxel group: 1.983, 1.700 and 1.602 mm(2), control: 1.071, 1.338 and 1.206 mm(2), respectively). Tubulin staining and electron microscopy revealed changes in microtubule assembly, which were limited to the intimal area. Vasocontractile function after paclitaxel treatment showed major impairment. CONCLUSIONS Local delivery of paclitaxel resulted in reduced neointimal stenosis and enlargement in vessel size. Both these effects contribute to a preservation of vessel shape and are likely to be caused by a structural alteration of the cytoskeleto

关键词：抗肿瘤药植物/投药和剂量缩窄病理性/病理学缩窄病理性/预防和控制紫杉酚/投药和剂量复发猪血管疾病/病理学血管疾病/预防和控制动物兔

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Magnesium and potassium supplementation in the prevention of diabetic vascular disease

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MEDICAL HYPOTHESES 2000年第3期55卷 263-265页

作者： Whang, R Sims, G Univ Hawaii Dept Med Honolulu HI 96822 USA Stanford Univ Dept Orthoped Palo Alto CA 94304 USA Vet Affairs Med Ctr Honolulu HI USA Vet Affairs Med Ctr Palo Alto CA 94304 USA

Vascular disease underlies many of the complications of diabetes and includes coronary, cerebral, renal, peripheral and retinal vascular abnormalities. Magnesium (Mg) and potassium (K) deficiencies occur frequently in diabetic patients. Because of the vasoconstrictive effects of hypomagnesemia and hypokalemia and the adverse effects of Mg and K deficiency on carbohydrate metabolism we hypothesize that routine Mg and K supplementation of all hypomagnesemic diabetics will ameliorate or prevent the ravages of diabetic vascular disease. (C) 2000 Harcourt Publishers Ltd.

关键词：糖尿病并发症镁/投药和剂量钾/投药和剂量血管疾病/并发症血管疾病/预防和控制人类

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断指再植280例术后血管危象的预防与护理

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中国误诊学杂志 2010年第29期10卷 7254-7255页

作者：王彤华广西医科大学第四附属医院骨一科广西柳州545005

2006-01-2009-10我院行断指再植术280例（398指）,术后采取有效的护理措施,预防和减少断指再植术后血管危象的发生,报道如下。

关键词：指损伤/外科学再植术手术后医护血管疾病/预防和控制

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Control of postprandial state abnormalities: meeting the challenge of type 2 diabetes?

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EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2000年第Sup2期30卷 19-24页

作者： Puig-Domingo, M Hosp Mataro Res Unit Carretera Cirera S-N Mataro 08304 Spain

The article discusses the management of non-insulin-dependent diabetes commonly known as type two diabetes. It states that type two diabetes commenced as a postprandial disorder characterized by glucose intolerance and lipid abnormalities. The author mentions that costs of diabetes included direct costs to patients and their families according to the International Diabetes Federation (IDF) Task Force on Diabetes Health Economics.

关键词：卫生保健提供糖尿病 2型/并发症糖尿病 2型/经济学糖尿病 2型/代谢疾病管理饭后期间危险血管疾病/预防和控制人类

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Vitamin E and memory: Is it vascular protection?

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NUTRITION REVIEWS 2000年第4期58卷 109-111页

作者： Miller, JW Univ Calif Davis Med Ctr Dept Med Pathol Sacramento CA 95817 USA

Vitamin E per unit serum cholesterol has been found to correlate with memory performance in a recent analysis of data from the Third National Health and Nutrition Examination Survey. Because vitamin E is thought to be protective against vascular disease, this finding is consistent with the growing body of evidence that implicates vascular disease and vascular disease risk factors in age-related cognitive decline and Alzheimer's disease.

关键词：胆固醇/血液记忆血管疾病/预防和控制维生素E/血液维生素E/生理学人类

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Rho激酶抑制剂预防心脏介入诊疗术后并发症481例疗效观察

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陕西医学杂志 2012年第9期41卷 1159-1161页

作者：周静高峰杜日映白怀生李晓莉延安大学附属医院心血管内科三病区延安716000

目的:观察Rho激酶抑制剂预防心脏介入诊疗术后并发症的临床疗效。方法:对住院经桡动脉行冠状动脉介入诊疗的患者481例于术后拔管前经鞘内注入相应药物,A组予以法舒地尔5mg,B组予以硝酸甘油200μg,C组予以生理盐水对照,观察是否出现桡动... 详细信息

目的:观察Rho激酶抑制剂预防心脏介入诊疗术后并发症的临床疗效。方法:对住院经桡动脉行冠状动脉介入诊疗的患者481例于术后拔管前经鞘内注入相应药物,A组予以法舒地尔5mg,B组予以硝酸甘油200μg,C组予以生理盐水对照,观察是否出现桡动脉痉挛、局部血肿、急性血管闭塞或狭窄等并发症。结果:经桡动脉介入治疗时,应用Rho激酶抑制剂法舒地尔可以更有效防治术后并发症发生,且不良反应发生率低。结论:Rho激酶抑制剂法舒地尔预防心脏介入诊疗术后并发症安全有效。

关键词：血管疾病/预防和控制硝酸甘油/治疗应用心脏导管插入术 @法舒地尔 @桡动脉冠脉介入术

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