检索结果-内蒙古大学图书馆

应用血管扩张剂和正性收缩能药物治疗心力衰竭的体会

引用

中华医学杂志 1983年第11期63卷 705-708页

作者：陈曙霞杜慧君李金禧常佩伦包世宏臧德良张世华陆惠华俞国瑞郑道声上海第二医学院附属第三人民医院内科

近十年来,对联合应用洋地黄和利尿剂治疗无效的难治性心力衰竭病例以及并发于急性心肌梗塞的泵衰竭,较多推荐用血管扩张剂治疗,并已取得一定的疗效,但在无血液动力学监测的条件下应用此方法应

关键词：心力衰竭/药物疗法血管收缩药/治疗应用血管舒张药/治疗应用

来源：评论

学校读者我要写书评

暂无评论

以血管扩张剂为主治疗慢性肾衰5例

引用

中华肾脏病杂志 1990年第2期6卷 124-125页

作者：马保民周叔南空军长春医院二内科肾病组

来源：评论

学校读者我要写书评

暂无评论

老年性痴呆的药物治疗

引用

中华老年医学杂志 1991年第4期10卷 241-243页

作者：李延锋北京医院脑系科　北京市，100730

来源：评论

学校读者我要写书评

暂无评论

氯沙坦治疗高血压病并发左室肥厚57例疗效观察

引用

陕西医学杂志 2005年第9期34卷 1136-1138页

作者：屈引贤赵小丽邓商智西安市中心医院干部科西安市第一医院心内科陕西省军区68409部队门诊部

目的:观察氯沙坦治疗原发性高血压病逆转左室肥厚的作用。方法:选择114例原发性高血压病并发左室肥厚的病人随机分为氯沙坦组和硝苯地平组。两组病人在治疗前后测收缩压、舒张压、心率、IVST、LVPWT。结果:治疗12周后,两组病人收缩压和... 详细信息

目的:观察氯沙坦治疗原发性高血压病逆转左室肥厚的作用。方法:选择114例原发性高血压病并发左室肥厚的病人随机分为氯沙坦组和硝苯地平组。两组病人在治疗前后测收缩压、舒张压、心率、IVST、LVPWT。结果:治疗12周后,两组病人收缩压和舒张压明显下降,氯沙坦组总有效率为91.2%。硝苯地平组总为89.5%,两组无显著性差异(P>0.05)。IVST和LVPWT的变化,氯沙坦组明显低于治疗前(P<0.01),硝苯地平组治疗后无明显降低(P>0.05),两组差别有非常显著意义(P<0.01)。结论:氯沙坦不但能够控制高血压而且能够逆转高血压引起的左室肥厚。

关键词：高血压/并发症肥大,左心室/诊断肥大,左心室/药物疗法血管舒张药/治疗应用原发性高血压病逆转左室肥厚治疗前后氯沙坦疗效观察并发

来源：评论

学校读者我要写书评

暂无评论

缬沙坦配伍卡维地洛治疗扩张型心肌病并发心力衰竭30例观察

引用

陕西医学杂志 2005年第9期34卷 1143-1145页

作者：张军科胡耀俊陕西省蓝田县医院西安710500 西安济仁医院

目的:探讨缬沙坦配伍卡维地洛对扩张型心肌病(DCM)并发心衰(HF)的临床疗效。方法:将60例DCM并发HF患者随机分为治疗组和对照组,每组30例。治疗组应用缬沙坦配伍卡维地洛,对照组应用依那普利,两组均常规应用洋地黄、利尿剂、硝酸盐制荆... 详细信息

目的:探讨缬沙坦配伍卡维地洛对扩张型心肌病(DCM)并发心衰(HF)的临床疗效。方法:将60例DCM并发HF患者随机分为治疗组和对照组,每组30例。治疗组应用缬沙坦配伍卡维地洛,对照组应用依那普利,两组均常规应用洋地黄、利尿剂、硝酸盐制荆。治疗前及治疗后3个月、6个月用超声心动图检测射血分数(EF),左室舒张期末内径(LVDD),室间隔厚度(IVS)左室后壁(LVPW),左房内径。结果:治疗6个月后,两组心功能均明显改善,治疗组LVDD60.4±4.1mm与治疗前67.4±6.2mm相比,P<0.01,EF52.0±6.0%与治疗前37.5±9.2%相比,P<0.01。结论;缬沙坦配伍卡维地洛能显著改善DCM并发HF心功能及心肌重构,改善生活质量,使再住院率下降。

关键词：心肌病,充血性/并发症心力衰竭,充血性/诊断心力衰竭,充血性/药物疗法肾上腺素能β受体拮抗剂/治疗应用血管舒张药/治疗应用扩张型心肌病卡维地洛治疗组缬沙坦并发

来源：评论

学校读者我要写书评

暂无评论

高压氧治疗冠心病期间扩血管药物应用观察一例

引用

医学临床研究 2004年第7期21卷 F003-F003页

作者：李译蓉湖南省怀化铁路医院高压氧科湖南怀化418000

1 病历患者,女,54岁.于2004年5月1日起无明显诱因出现右侧上肢麻木,呈间歇性发作,伴头昏、胀痛(以额顶区较明显),枕区有麻木感,视物模糊,无视物旋转.于2004年5月10日入院,患者曾有高血压、冠心病病史多年.体格检查:生命体征正常,神清,... 详细信息

1 病历患者,女,54岁.于2004年5月1日起无明显诱因出现右侧上肢麻木,呈间歇性发作,伴头昏、胀痛(以额顶区较明显),枕区有麻木感,视物模糊,无视物旋转.于2004年5月10日入院,患者曾有高血压、冠心病病史多年.体格检查:生命体征正常,神清,精神差,心尖搏动位于左锁骨中线第五肋间交界处,心前区无震颤,心脏浊音界稍向左下扩大,节律齐,无早搏,腹部无异常体征.颈椎片:颈椎退变,第5、6颈椎间盘病变.头部CT无异常.诊断结果:①基底动脉供血不足;②颈椎病;③高血压心脏病;④冠心病,心功能2级;⑤高血压病.入院后给予扩血管、活血、降压,护脑等对症支持治疗(5%葡萄糖250毫升加丁洛地尔0.1g静脉滴注QD; 5%葡萄糖250毫升加云南灯盏花20毫升静脉滴注QD; 5%葡萄糖250毫升加胞二磷胆碱0.5 g静脉滴注QD; 麦利平1片QD;肠溶阿司匹林75毫克QD; 比索洛尔2.5毫克QD; 更年康3片tid; 活力苏口服液10毫升QN;曲美他嗪20毫克tid),同时申请高压氧治疗.

关键词：冠状动脉疾病/治疗高压氧血管舒张药/治疗应用

来源：评论

学校读者我要写书评

暂无评论

Responses to constant work rate bicycle ergometry exercise in primary pulmonary hypertension:: The effect of inhaled nitric oxide

引用

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2000年第2期36卷 547-556页

作者： Riley, MS Pórszász, J Engelen, MPKJ Shapiro, SM Brundage, BH Wasserman, K Univ Calif Los Angeles Harbor Med Ctr Div Resp & Crit Care Physiol & Med Torrance CA 90509 USA Univ Calif Los Angeles Harbor Med Ctr St Johns Cardiovasc Res Ctr Div Cardiol Torrance CA 90509 USA

OBJECTIVES The purpose of this study was to investigate the responses oipatients with primary pulmonary hypertension (PPH) to constant work rate exercise and to examine the effect of nitric oxide (NO) inhalation. BACKGROUND Maximal exercise tolerance is reduced in PPH, but gas exchange responses to constant work rate exercise have not been defined. We hypothesized that increased pulmonary vascular resistance in PPH would reduce the rate of rise of minute oxygen consumption in response to a given work rate. Because NO may lower pulmonary Vascular pressures in PPH, we also postulated that inhaled NO might ameliorate gas exchange abnormalities. METHODS Nine PPH patients and nine matched normal subjects performed 6-min duration constant work rate cycle ergometry exercise (33.9 +/- 13.4 W). Patients performed two experiments: breathing air and breathing air with NO (20 ppm). Preexercise right ventricular systolic pressure was assessed by Doppler echocardiography. Normal subjects performed the air experiment only. Gas exchange and heart rate responses were characterized by fitting monoexponential curves. RESULTS In PPH patients, resting right ventricular systolic pressure fell after NO inhalation (from 83.8 +/- 16.9 to 73.9 +/- 21.6 mm Hg, p < 0.01, analysis of variance with Tukey correction), but not after breathing air alone (from 88.0 +/- 20.8 to 86.7 +/- 20.6 mm Hg, p = NS). Nitric oxide did not affect any of the gas exchange responses. Minute oxygen consumption was similar by the end of exercise in patients and normals, but increased more slowly in patients (mean response time [MRT]: air, 63.17 +/- 14.99 s;NO, 61.60 +/- 15.45 s) than normals (MRT, 32.73 +/- 14.79, p < 0.01, analysis of variance, Tukey test). Minute oxygen consumption kinetics during recovery were slower in patients (MRT air: 82.50 +/- 29.94 s;NO, 73.36 +/- 15.87 s) than in normals (MRT, 34.59 +/- 7.11 s, p < 0.01). Heart rate kinetics during exercise and recovery were significantly slower in patients

关键词：心排血量/药物作用运动(Exercise)/生理学运动试验血流动力学/药物作用高血压肺性/药物疗法高血压肺性/病理生理学一氧化氮/药理学一氧化氮/治疗应用氧耗量肺换气/药物作用血管舒张药/药理学血管舒张药/治疗应用成年人女(雌)性人类中年人

来源：评论

学校读者我要写书评

暂无评论

Trimetazidine:: a novel protective role via maintenance of Na⁺ /K⁺-ATPase activity?

引用

CARDIOVASCULAR RESEARCH 2000年第4期47卷 637-639页

作者： Cross, HR Duke Univ Med Ctr Dept Pathol Durham NC 27710 USA

来源：评论

学校读者我要写书评

暂无评论

Fenoldopam mesylate blocks reductions in renal plasma flow after radiocontrast dye infusion: A pilot trial in the prevention of contrast nephropathy

引用

AMERICAN HEART JOURNAL 2002年第5期143卷 894-903页

作者： Tumlin, JA Wang, A Murray, PT Mathur, VS Emory Univ Sch Med Div Renal Atlanta GA 30322 USA Duke Univ Durham NC 27706 USA Univ Chicago Chicago IL 60637 USA Univ Calif San Francisco San Francisco CA 94143 USA

Background Radiocontrast nephropathy (RCN) is a common source of acute renal failure in hospitalized patients and is associated with increased morbidity and mortality rates. Fenoldopam mesylate is a dopomine A1 receptor agonist that augments renal plasma flow (RPF) in patients with normotensive and hypertensive conditions, To determine whether fenoldopam mesylate attenuates reductions in RPF after contrast infusion, we conducted a double-blind, randomized, placebo-controlled pilot trial of fenoldopam mesylate in patients who underwent contrast angiography. Methods Fifty-one patients with chronic renal insufficiency (creatinine level, 2.0-5.0 mg/dL) who were undergoing contrast angiography were screened, and 45 patients were randomized to receive normal saline solution (1/2 NS) or 1/2 NS plus fenoldopam mesylate at 0.1 mug/kg/min at lease I hour before infusion with contrast dye. Serum creatinine level was measured at baseline and at 24, 48, and 72 hours after angiography. The primary endpoint was change in RPF I hour after contrast infusion. The secondary endpoint was incidence of RCN, defined as a 0.5 mg/dL or a 25% rise in serum creatinine level at 48 hours. Results RPF at I hour after angiography was 15.8% above baseline in the fenoldopam mesylate group compared with 33.2% below baseline in the 1/2 NS group (P < .05). The incidence rate of RCN at 48 hours was A 1.0% in the 1/2 NS group versus 21% in the fenoldopam mesylate group (P = .148). Among patients with diabetes, the incidence rate of RCN tended to be higher in the 1/2 NS group compared with the fenoldopam mesylate group (64% vs 33%;P = .14), The peak serum creatinine level at 72 hours after contrast infusion was significantly higher at in the 1/2 NS group (creatinine level, 3.6 +/- 1.0 mg/dL) compared with the fenoldopam mesylate group (creatinine level, 2.8 +/- 0.35 mg/dL;P < .05). RPF was significantly (P < .0001) reduced in patients with RCN compared with patients in whom RCN did not develop. Conclusio

关键词：双盲法非诺多泮/治疗应用肾/血液供给肾/药物作用肾功能衰竭急性/化学诱导肾功能衰竭急性/预防和控制试点项目前瞻性研究血管舒张药/治疗应用 p-氨基马尿酸/诊断应用成年人女(雌)性人类男(雄)性

来源：评论

学校读者我要写书评

暂无评论

Effects of trimetazidine on oxidant/antioxidant status in trinitrobenzenesulfonic acid-induced chronic colitis

引用

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 2000年第8期59卷 641-652页

作者： Girgin, F Karaoglu, Ö Erkus, M Tüzün, S Özütemiz, Ö Dinçer, Ç Batur, Y Tanyalçin, T Ege Univ Sch Med Dept Biochem TR-35100 Izmir Turkey Ege Univ Sch Med Dept Gastroenterol Izmir Turkey Adnan Menderes Univ Sch Med Dept Pathol Aydin Turkey

Trimetazidine (TMZ), an anti-ischemic agent with proposed antioxidant properties, was used in a chronic colitis model in order to evaluate its effectiveness as a therapeutic agent in chronic colitis. Treatment of male Swiss Albino rats with ethanol (50%) and trinitrobenzenesulfonic acid (TNBS) (30 mg/kg) produced colitis as evidenced by histopathologic damage and inflammatory alterations, lipid peroxidation [increased malondialdehyde (MDA) levels], and enhanced neutrophil infiltration [increased myeloperoxidase (MPO) activity] without marked change in glutathione status. Administration of TMZ (5 mg/kg) to TNBS-treated rats failed to affect the TNBS-induced changes in histopathology and MPO activities. Unexpectedly, intrarectal (ir) administration of TMZ significantly elevated colonic MDA levels to a greater extent than TNBS alone. Intraperitoneal (ip) TMZ treatment seemed to increase total glutathione (tGSH), GSH, and GSH/GSSg values. In conclusion, our results demonstrated that (a) ir administration of ethanol and TNBS is an effective way of inducing a chronic colitis model, (b) inflammation and lipid peroxidation augment tissue damage in the chronic colitis model, (c) ip TMZ treatment significantly inhibits MDA production in the chronic colitis model, (d) TMZ treatment is more effective via the ip compared to ir route, and (e) TMZ seems to show its antioxidant effect via preserving the tissue's GSH/GSSG ratios.

关键词：投药直肠慢性病结肠炎/化学诱导结肠炎/药物疗法结肠炎/代谢结肠炎/病理学乙醇谷胱甘肽/代谢注射腹腔内脂质过氧化作用/药物作用丙二醛/代谢过氧化物酶/代谢大鼠 Sprague-Dawley 溶剂曲美他嗪/投药和剂量曲美他嗪/治疗应用三硝基苯磺酸血管舒张药/投药和剂量血管舒张药/治疗应用动物男(雄)性大鼠

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：