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检索条件"主题词=血管舒张药/药代动力学"
10 条 记 录,以下是1-10 订阅
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Inhibition of CYP2D6 by quinidine and its effects on the metabolism of cilostazol
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CLINICAL PHARMACOKINETICS 1999年 第2-Sup期37卷 41-51页
作者: Bramer, SL Suri, A Otsuka Amer Pharmaceut Inc Dept Clin Pharmacokinet Pharmacodynam & Metab Rockville MD 20850 USA
Objective: In vitro results are inconclusive as to whether cilostazol is metabolised by cytochrome P450 isoenzyme 2D6 (CYP2D6). The goals of this study were (1) to assure the dose of quinidine and timing relative to c... 详细信息
来源: 评论
Relative bioavailability and effects of a high fat meal on single dose cilostazol pharmacokinetics
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CLINICAL PHARMACOKINETICS 1999年 第2-Sup期37卷 13-23页
作者: Bramer, SL Forbes, WP Otsuka Amer Pharmaceut Inc Dept Clin Pharmacokinet Pharmacodynam & Metab Rockville MD 20850 USA
Objectives: The objectives of this research were to (1) assess the relative bioavailability following administration of a 100mg cilostazol suspension versus 100mg tablet;(2) assess dosage form equivalency (2 x 50mg co... 详细信息
来源: 评论
Endothelin receptor antagonism does not prevent the development of in vivo glyceryl trinitrate tolerance in the rat
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2000年 第2期295卷 578-585页
作者: Ratz, JD Fraser, AB Rees-Milton, KJ Adams, MA Bennett, BM Queens Univ Fac Hlth Sci Dept Pharmacol & Toxicol Kingston ON K7L 3N6 Canada
There is evidence that increased endothelial production of endothelin-1 (ET-1) may contribute to glyceryl trinitrate (GTN) tolerance. We used the competitive ETA receptor antagonist ZD2574 to determine whether chronic... 详细信息
来源: 评论
4-(3-chloro-4-methoxybenzyl) aminophthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5
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JOURNAL OF MEDICINAL CHEMISTRY 2000年 第13期43卷 2523-2529页
作者: Watanabe, N Adachi, H Takase, Y Ozaki, H Matsukura, M Miyazaki, K Ishibashi, K Ishihara, H Kodama, K Nishino, M Kakiki, M Kabasawa, Y Eisai & Co Ltd Tsukuba Res Labs Tsukuba Ibaraki 3002635 Japan
We synthesized various 4-(3-chloro-4-methoxybenzyl)aminophthalazines substituted at the 1- and 6-positions and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) and their vasorelaxant activity in i... 详细信息
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Effect of omeprazole on the metabolism of cilostazol
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CLINICAL PHARMACOKINETICS 1999年 第2-Sup期37卷 53-59页
作者: Suri, A Bramer, SL Otsuka Amer Pharmaceut Inc Dept Clin Pharmacokinet Pharmacodynam & Metab Rockville MD 20850 USA
Objective: In vitro results suggest that cilostazol is metabolised by cytochrome P450 (CYP) isoforms 1A2, 2D6, 3A4 and 2C19. This study was designed to evaluate the effect of concomitant administration of omeprazole (... 详细信息
来源: 评论
Effect of hepatic impairment on the pharmacokinetics of a single dose of cilostazol
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CLINICAL PHARMACOKINETICS 1999年 第2-Sup期37卷 25-32页
作者: Bramer, SL Forbes, WP Otsuka Amer Pharmaceut Inc Dept Clin Pharmacokinet Pharmacodynam & Metab Rockville MD 20850 USA
Objective: The pharmacokinetic profiles of cilostazol and its metabolites following a single oral dose of cilostazol 100mg were compared between individuals with impaired and normal liver function. Design: The study w... 详细信息
来源: 评论
Effect of renal impairment on the pharmacokinetics of cilostazol and its metabolites
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CLINICAL PHARMACOKINETICS 1999年 第2-Sup期37卷 33-40页
作者: Mallikaarjun, S Forbes, WP Bramer, SL Otsuka Amer Pharmaceut Inc Dept Clin Pharmacokinet Pharmacodynam & Metab Rockville MD 20850 USA
Objective: The pharmacokinetics of cilostazol were studied in patients with mild, moderate and severe renal impairment and in healthy volunteers after administration of 50mg single and multiple doses of cilostazol. De... 详细信息
来源: 评论
Effect of multiple cilostazol doses on single dose lovastatin pharmacokinetics in healthy volunteers
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CLINICAL PHARMACOKINETICS 1999年 第2-Sup期37卷 69-77页
作者: Bramer, SL Brisson, J Corey, AE Mallikaarjun, S Otsuka Amer Pharmaceut Inc Dept Clin Pharmacokinet Pharmacodynam & Metab Rockville MD 20850 USA
Objective: To assess the effects of cilostazol on lovastatin pharmacokinetics. Design: This was a single-centre, open-label, multiple dose, sequential treatment study. Participants received single oral doses of lovast... 详细信息
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Cilostazol pharmacokinetics after single and multiple oral doses in healthy males and patients with intermittent claudication resulting from peripheral arterial disease
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CLINICAL PHARMACOKINETICS 1999年 第2-Sup期37卷 1-11页
作者: Bramer, SL Forbes, WP Mallikaarjun, S Otsuka Amer Pharmaceut Inc Dept Clin Pharmacokinet Pharmacodynam & Metab Rockville MD 20850 USA
Objective: To study the pharmacokinetics of cilostazol following single oral administration of 50 to 200mg in healthy young males, and after repeated oral administration of 100mg every 12 hours to patients with periph... 详细信息
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Dypiridamole, a cGMP phosphodiesterase inhibitor, transiently improves the response to inhaled nitric oxide in two newborns with congenital diaphragmatic hernia
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INTENSIVE CARE MEDICINE 1999年 第3期25卷 300-303页
作者: Thébaud, B Saizou, C Farnoux, C Hartman, JF Mercier, JC Univ Paris 07 Fac Med Xavier Bichat Hop Robert Debre Serv Pediat Reanimat F-75019 Paris France
Introduction: Congenital diaphragmatic hernia (CDH) remains a frusta;ling cause of respiratory failure associated with persistent pulmonary hypertension of the newborn (PPHN). Although inhaled nitric oxide (iNO) is ef... 详细信息
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