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EFFECT OF SOMAESTHETIC DENERVATION UPON VASOCONSTRICTOR RESPONSE IN HUMAN SUBCUTANEOUS TISSUE

ACTA PHYSIOLOGICA SCANDINAVICA 1976年第3期96卷 431-432页

作者： HENRIKSEN, O RIGS HOSP COPENHAGEN DEPT NUCL MED COPENHAGEN DENMARK

The vasoconstrictor response in the subcutaneous adipose tissue to an increase in vascular transmural pressure is unaffected by somatesthetic denervation. The mechanism might be a sympathetic axon reflex, or an intrin... 详细信息

关键词：脂肪组织/血液供给脂肪组织/神经支配血压去神经支配局部血流脊神经/外科学腓肠神经/外科学血管阻力血管舒缩系统/生理学人类

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EFFECTS OF HEXAMETHONIUM, BIPERIDEN AND PHENTOLAMINE ON VASOCONSTRICTIVE EFFECTS OF OCULOMOTOR NERVE-STIMULATION IN RABBITS

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EXPERIMENTAL EYE RESEARCH 1976年第6期23卷 615-622页

作者： BILL, A STJERNSCHANTZ, J ALM, A UNIV UPPSALA CTR BIOMED INST PHYSIOL & MED BIOPHYS UPPSALA SWEDEN

In rabbits intracranial stimulation of the oculomotor nerve causes vasoconstriction in the anterior uvea and vasodilation in the choroid and an attempt was made to analyze the mechanism involved in the vasoconstrictive response to stimulation. The oculomotor nerve was stimulated unilaterally, and regional blood flow was determined in both eyes using radioactively labeled microspheres. Hexamethonium bromide, in a dose of 40-80 mg/kg body weight, completely abolished the vasoconstrictive response in the iris and the ciliary processes. The blood flow in all parts of the uvea tended to be higher on the stimulated side than on the control side. The parasympatholytic agent biperiden lactate, in a dose of 2.5-5 mg/kg body wt, reduced the response in the iris, but no significant change was observed in the ciliary processes. The .alpha.-adrenergic blocking agent phentolamine chloride, in a dose of 10-15 mg/kg body wt had no significant effect on the response in the iris but reversed the effect in the ciliary processes. A combination of biperiden and phentolamine totally abolished the vasoconstrictive response in the iris, and there was increased blood flow in the ciliary processes on the stimulated side. Intracranial stimulation of the oculomotor nerve and possibly of adjacent structures apparently caused a release of vasodilating and vasoconstricting agents in the uvea. The vasoconstrictive effect was partly muscarinic, possibly due to miosis, and partly due to stimulation of receptors sensitive to phentolamine. A ganglion or ganglion-like receptors, somewhere between the site of stimulation and the effector cells, seem to be involved in the transmission of the vasoconstrictive impulses.

关键词：比哌立登/药理学脉络膜/血液供给六甲胺化合物/药理学动眼神经/生理学酚妥拉明/药理学哌啶类/药理学葡萄膜/血液供给血管舒缩系统/药物作用血管舒缩系统/生理学动物女(雌)性男(雄)性兔

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Genetic determinants of coronary vasomotor tone in humans

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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2001年第4期281卷 H1465-H1468页

作者： Heusch, G Erbel, R Siffert, W Univ Klinikum Essen Abt Pharmakol D-45122 Essen Germany Univ Klinikum Essen Abt Kardiol D-45122 Essen Germany Univ Klinikum Essen Abt Pathophysiol D-45122 Essen Germany

Editorial. Discusses the determinants of coronary vasomotor tone in humans. Number of single nucleotide polymorphisms that comprised human genome; Details of G protein beta-3 subunit gene C825T polymorphism and coronary vasoconstrictor responsiveness; Endothelial nitric oxide synthase polymorphism and coronary spasm; Detection of other polymorphisms that are associated with cardiovascular disease.

关键词：冠状动脉循环/遗传学冠状血管痉挛/遗传学 GTP结合蛋白质类/遗传学一氧化氮合酶/遗传学一氧化氮合酶Ⅲ型多态现象遗传/生理学蛋白质亚型/遗传学血管舒缩系统/生理学人类

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Relation of preservation of nitric oxide-dependent coronary vasomotor function to plasma vitamin C concentrations in cardiac transplant recipients

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AMERICAN JOURNAL OF CARDIOLOGY 2000年第4期86卷 460-+页

作者： Fang, JC Kinlay, S Hikita, H Suh, JH Piana, RN Selwyn, AP Frei, B Morrow, JD Ganz, P Brigham & Womens Hosp Div Cardiovasc Boston MA 02115 USA Oregon State Univ Linus Pauling Inst Corvallis OR 97331 USA Vanderbilt Univ Dept Med & Pharmacol Nashville TN USA

The contribution of oxidant stress to coronary endothelial dysfunction in cardiac transplant recipients is not known. We found that the plasma vitamin C concentration, but not plasma F-2-isoprostanes, was significantl... 详细信息

关键词：乙酰胆碱/药理学抗氧化剂抗坏血酸/血液抗坏血酸/生理学生物利用度色谱法高压液相冠状血管/药物作用冠状血管/生理学内皮血管/药物作用内皮血管/生理学心脏移植/生理学多元分析一氧化氮/生理学硝酸甘油/药理学手术后期间血管舒张药/药理学血管舒缩系统/药物作用血管舒缩系统/生理学成年人老年人女(雌)性人类男(雄)性中年人

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INTERACTIONS BETWEEN LOCAL AND REFLEX INFLUENCES ON HUMAN FOREARM SKIN BLOOD-FLOW

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JOURNAL OF APPLIED PHYSIOLOGY 1976年第6期41卷 826-831页

作者： JOHNSON, JM BRENGELMANN, GL ROWELL, LB UNIV WASHINGTON SCH MED DEPT PHYSIOL & BIOPHYS SEATTLE WA 98195 USA UNIV WASHINGTON SCH MED DEPT MED & SCH NURSING SEATTLE WA 98195 USA

A 3-part experiment examined interactions between local and reflex influences on forearm skin blood flow (SkBF). In part I locally increasing arm skin temperature (Tsk) to ***. C was not associated with increases in underlying forearm muscle blood flow, esophageal temperature (Tes) or forearm blood flow in the contralateral cool arm. In part II whole-body Tsk was held at 38 or ***. C and the surface temperature of one arm held at 38 or ***. C for prolonged periods. SkBF in the heated arm rose rapidly with the elevation in body Tsk and arm Tsk continued to rise as Tes rose. SkBF in the arm kept at ***. C paralleled rising Tes. In 6 studies SkBF in the cool arm ultimately converged with SkBF in the heated arm. In 8 other studies, heated arm SkBF maintained an offset above cool arm SkBF throughout the period of whole-body heating. In part III local arm Tsk of ***. C did not abolish skin vasoconstrictor response to lower body negative pressure. Local and reflex influences to skin may interact to modify the degree but not the pattern of skin vasomotor response.

关键词：安替比林/代谢前臂/代谢碘放射性同位素肌/代谢反射局部血流皮肤/血液供给皮肤温度血管舒缩系统/生理学成年人人类男(雄)性

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Endothelium-independent coronary microvascular function: All vessels are not created equally

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AMERICAN HEART JOURNAL 2003年第4期145卷 567-568页

作者： Hasdai, D Rabin Med Ctr Dept Cardiol IL-49100 Petah Tiqwa Israel

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EFFECTS OF OCULOMOTOR NERVE-STIMULATION ON OCULAR BLOOD-FLOW IN RABBITS AFTER SYMPATHETIC DENERVATION

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EXPERIMENTAL EYE RESEARCH 1976年第6期23卷 609-613页

作者： ALM, A STJERNSCHANTZ, J BILL, A UNIV UPPSALA CTR BIOMED INST PHYSIOL & MED BIOPHYS UPPSALA SWEDEN

Bilateral cervical sympathectomy was performed in rabbits to produce sympathetic denervation of both eyes. The effect was checked by testing the sensitivity of the dilator muscle of the iris. The effect of intracranial stimulation of the oculomotor nerve on ocular blood flow was determined 3-8 wk after sympathectomy using radioactively labeled microspheres. Indomethacin was given to prevent the release of prostaglandins and biperiden was used to abolish muscarinic effects in the eye. Insertion of the electrode and/or test stimulation tended to cause a long-lasting vasodilation in the uvea. In the iris the blood flow on the side of the electrode was 142 .+-. 13% of that in the control eyes before stimulation of the nerve. During stimulation it was 75 .+-. 13% of that in the control eyes. In the ciliary processes the corresponding figures were 118 .+-. 16% and 79 .+-. 7% and in the choroid 105 .+-. 5% and 106 .+-. 5%, respectively. It seems unlikely that the vasoconstrictive response to oculomotor nerve stimulation is due to adrenergic nerves within the anterior uvea, and it is probably caused by some transmitter other than norepinephrine.

关键词：睫状体/血液供给虹膜/血液供给动眼神经/生理学交感神经切除术葡萄膜/血液供给血管舒缩系统/生理学动物女(雌)性男(雄)性兔

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Physiological changes in blood volume

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Critical Reviews in Clinical Laboratory Sciences 1975年第1期6卷 67-79页

作者： Besa, Emmanuel C. Hematology Research Laboratory Presbyterian-University Pennsylvania Medical Center Philadelphia PA United States

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关键词：醛固酮/生理学高海拔雄激素类/生理学血量/药物作用骨髓/生理学骨髓细胞毛细血管通透性红细胞衰老红细胞/生理学红细胞生成红细胞生成素/生理学用力生长激素/生理学血细胞比容肾/生理学苯丙酸诺龙/药理学渗透压氧耗量血浆容量催乳素/生理学放射性同位素稀释技术休息甲状腺激素类/生理学血管舒缩系统/生理学血管升压素类/生理学女(雌)性人类婴儿新生男(雄)性妊娠

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Gene therapy of hypertensive vascular injury

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Current Hypertension Reports 2000年第1期2卷 92-97页

作者： Chu, Yi Faraci, Frank M. Heistad, Donald D. Cardiovascular Center Department of Internal Medicine University of Iowa Iowa City IA 52242 United States Cardiovascular Center Department of Internal Medicine and Pharmacology University of Iowa College of Medicine Iowa City IA 52242 United States Cardiovascular Center Department of Internal Medicine and Pharmacology University of Iowa Iowa City IA 52242 United States

Hypertension and vascular injury usually require prolonged treatment, and compliance is a key to efficacy for pharmacologically-based antihypertensive therapy. Gene therapy has the potential to be long lasting, with few side effects. Recent studies have provided promising results, in which hypertension can be treated by either augmentation of vasodilation or inhibition of vasocon-striction through gene transfer in experimental models. Gene transfer is also becoming useful for the study of mechanisms of physiologic and pathophysiologic conditions, including hypertension. In this mini-review, we summarize some recent studies in this area of research, and suggest some areas where progress is needed t advance the research toward gene therapy. Copyright © 2000 by Current Science Inc.

关键词：基因疗法基因转移技术高血压/病理学高血压/治疗血管收缩/药物作用血管舒张药/治疗应用血管舒缩系统/药物作用血管舒缩系统/生理学人类

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The interplay of central and peripheral factors in irreversible hemorrhagic shock

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Progress in Cardiovascular Diseases 1975年第2期18卷 147-180页

作者： Zweifach, Benjamin W. Fronek, Arnost Department of AMES University of California San Diego CA United States Department of Bioengineering University of California La Jolla CA United States

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