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检索条件"主题词=表皮生长因子/生理学"
26 条 记 录,以下是1-10 订阅
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EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake
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CELL 1999年 第5期96卷 677-687页
作者: Wilde, A Beattie, EC Lem, L Riethof, DA Liu, SH Mobley, WC Soriano, P Brodsky, FM Univ Calif San Francisco Dept Immunol & Microbiol GW Hooper Fdn San Francisco CA 94143 USA Univ Calif San Francisco Dept Biopharmaceut Sci San Francisco CA 94143 USA Univ Calif San Francisco Dept Pharmaceut Chem San Francisco CA 94143 USA Univ Calif San Francisco Dept Physiol San Francisco CA 94143 USA Univ Calif San Francisco Dept Neurol San Francisco CA 94143 USA Univ Calif San Francisco Dept Anat San Francisco CA 94143 USA Fred Hutchinson Canc Res Ctr Div Basic Sci Seattle WA 98109 USA
Epidermal growth factor (EGF) binding to its receptor causes rapid phosphorylation of the clathrin heavy chain at tyrosine 1477, which lies in a domain controlling clathrin assembly. EGF-mediated clathrin phosphorylat... 详细信息
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Role of arrestins in endocytosis and signaling of α2-adrenergic receptor subtypes
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JOURNAL OF BIOLOGICAL CHEMISTRY 1999年 第16期274卷 11253-11259页
作者: DeGraff, JL Gagnon, AW Benovic, JL Orsini, MJ Thomas Jefferson Univ Kimmel Canc Inst Dept Microbiol & Immunol Philadelphia PA 19107 USA
We investigated the role of arrestins in the trafficking of human alpha(2)-adrenergic receptors (alpha(2)-ARs) and the effect of receptor trafficking on p42/p44 RAP kinase activation. alpha(2)-ARs expressed in COS-1 c... 详细信息
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Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-α, Erk-1, and p38 MAPK signaling pathways
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第16期275卷 12353-12359页
作者: Yoon, YM Oh, CD Kim, DY Lee, YS Park, JW Huh, TL Kang, SS Chun, JS Kyungpook Natl Univ Dept Biol Taegu 702701 South Korea Kyungpook Natl Univ Dept Biochem Taegu 702701 South Korea Kyungpook Natl Univ Dept Genet Engn Taegu 702701 South Korea
During limb development, epithelial cells in the apical ectodermal ridge keep the underlying mesenchymal cells in a proliferative state preventing differentiation by secreting signaling molecules such as epidermal gro... 详细信息
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Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第7期275卷 5096-5103页
作者: Wu, LW Mayo, LD Dunbar, JD Kessler, KM Baerwald, MR Jaffe, EA Wang, DF Warren, RS Donner, DB Indiana Univ Sch Med Walther Oncol Ctr Indianapolis IN 46202 USA Indiana Univ Sch Med Dept Microbiol & Immunol Indianapolis IN 46202 USA Interfaith Med Ctr Dept Med Brooklyn NY 11238 USA Cornell Univ Med Ctr New York NY 10021 USA SUNY Hlth Sci Ctr Brooklyn NY 11203 USA Univ Calif San Francisco Dept Surg San Francisco CA 94143 USA
This study was initiated to identify signaling proteins used by the receptors for vascular endothelial cell growth factor KDR/FlK1, and Flt1, Two-hybrid cloning and immunoprecipitation from human umbilical vein endoth... 详细信息
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Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor-differentiated PC12 cells
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第16期275卷 12095-12101页
作者: McGinty, A Chang, YWE Sorokin, A Bokemeyer, D Dunn, MJ Med Coll Wisconsin Dept Med Milwaukee WI 53226 USA Med Coll Wisconsin Cardiovasc Res Ctr Milwaukee WI 53226 USA Univ Bonn Med Poliklin D-53111 Bonn Germany
Cyclooxygenase-2 (Cox-2), an enzyme responsible for catalyzing the committed step in prostanoid biosynthesis, is the product of an immediate early gene capable of being up-regulated by diverse stimuli. Significantly C... 详细信息
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The internalization and endosomal trafficking of the EGF receptor in response to EGF is delayed in the waved-2 mouse liver
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2000年 第3期267卷 881-886页
作者: Keegan, BP Sheflin, LG Spaulding, SW VA Western New York Healthcare Syst Buffalo NY 14215 USA SUNY Buffalo Dept Physiol & Biophys Buffalo NY 14215 USA SUNY Buffalo Dept Med Buffalo NY 14215 USA
The EGF receptor in waved-2 mice contains a point mutation that renders it kinase deficient. We investigated how the waved-2 mutation affects the internalization and endosomal trafficking of the receptor in vivo in re... 详细信息
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Regulation of porcine adipogenesis in vitro, as compared with other species
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DOMESTIC ANIMAL ENDOCRINOLOGY 1999年 第2-3期17卷 257-267页
作者: Boone, C Grégoire, F Remacle, C Univ Catholique Louvain Fac Sci Biol Cellulaire Lab Unite Biol Anim B-1348 Louvain Belgium Parke Davis Lab Mol Genet Alameda CA 94505 USA
In vitro studies, mostly performed on murine cell lines, allowed us to identify the role played by hormonal agents, second-messenger pathways, extracellular matrix proteins, and transcription factors in adipose conver... 详细信息
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Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1999年 第11期96卷 6235-6240页
作者: Dong, JY Opresko, LK Dempsey, PJ Lauffenburger, DA Coffey, RJ Wiley, HS Univ Utah Dept Pathol Salt Lake City UT 84132 USA Vanderbilt Univ Dept Med Nashville TN 37232 USA Vet Affairs Med Ctr Nashville TN 37232 USA MIT Div Bioengn & Environm Hlth Cambridge MA 02139 USA MIT Canc Res Ctr Cambridge MA 02139 USA
Ligands that activate the epidermal growth factor receptor (EGFR) are synthesized as membrane-anchored precursors that appear to be proteolytically released by members of the ADAM family of metalloproteases. Because m... 详细信息
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Mathematical modelling of juxtacrine patterning
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BULLETIN OF MATHEMATICAL BIOLOGY 2000年 第2期62卷 293-320页
作者: Wearing, HJ Owen, MR Sherratt, JA Heriot Watt Univ Dept Math Edinburgh EH14 4AS Midlothian Scotland Univ Utah Dept Math Salt Lake City UT 84112 USA
Spatial pattern formation is one of the key issues in developmental biology. Some patterns arising in early development have a very small spatial scale and a natural explanation is that they arise by direct cell-cell ... 详细信息
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Growth factors: Importance in wound healing and maintenance of transparency of the cornea
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PROGRESS IN RETINAL AND EYE RESEARCH 2000年 第1期19卷 113-129页
作者: Imanishi, J Kamiyama, K Iguchi, I Kita, M Sotozono, C Kinoshita, S Kyoto Prefectural Univ Med Dept Microbiol Kamikyo Ku Kyoto 6028566 Japan Kyoto Prefectural Univ Med Dept Ophthalmol Kamikyo Ku Kyoto 6028566 Japan
The mechanism of corneal wound healing has not been clarified yet. However, evidence has accumulated that various kinds of growth factor such as epidermal growth factor (EGF), fibroblast growth factor (FGF), transform... 详细信息
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