目的:探讨表观扩散系数(ADC)对肺腺癌多发脑转移全脑放疗联合全身化疗疗效的预测作用。方法:选取青岛大学附属医院2019年7月~2023年7月收治的60例肺腺癌合并多发脑转移行WBRT联合化疗的患者,于治疗前、治疗开始后12周内行磁共振弥散加权成像检查测定ADC值。依据实体瘤的疗效评价标准(RECIST)评价疗效,讨论治疗前MRI扩散加权成像表观扩散系数(pre-ADCmean)、δADC值与放化疗疗效之间的关系。结果:60例患者中同步放化疗治疗有效者32例,无效者28例。治疗有效组pre-ADCmean高于治疗无效组(P 0.70,有一定预测价值。结论:3.0T-MRI扩散加权成像表观扩散系数可预测肺腺癌多发脑转移行全脑放疗联合化疗疗效。Objective: The objective was to evaluate the performance of ADC as a predictor of treatment outcomes associated with WBRT and chemotherapeutic agents in patients affected by lung adenocarcinoma (LUAD) originating in brain metastases (BMs). Methods: A retrospective analysis was conducted of 60 patients with LUAD with BMs who underwent WBRT and chemotherapy at the Affiliated Hospital of Qingdao University from July 2019 to July 2023, and measured the ADC value by DWI imaging before and within 12 weeks after treatment. According to the response evaluation criteria in solid tumors (RECIST), the efficacy was evaluated, and the relationships between pre-ADCmean and δADC values on MRI diffusion-weighted imaging and the efficacy of radiotherapy and chemotherapy were discussed. Results: Among the 60 patients, there were 32 responded to chemoradiotherapy, while 28 did not. The pre-ADCmean values of the effective group was higher than that of the ineffective group (P 0.70. Conclusion: The apparent diffusion coefficient of 3.0T-MRI diffusion-weighted imaging can predict the efficacy of whole brain radiotherapy combined with chemotherapy for multiple brain metastases from lung adenocarcinoma.
目的探讨ADC值在区分肌肉骨骼系统肿瘤良恶性中的作用。方法对33例患有肌肉骨骼系统肿瘤的患者进行MR常规T1加权,T2加权,压脂T2加权检查,以及3D Fast SPGR动态增强成像。MR扩散加权成像采用SS-EPI序列,b值分别取0、700 s/mm^2,在动态增...
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目的探讨ADC值在区分肌肉骨骼系统肿瘤良恶性中的作用。方法对33例患有肌肉骨骼系统肿瘤的患者进行MR常规T1加权,T2加权,压脂T2加权检查,以及3D Fast SPGR动态增强成像。MR扩散加权成像采用SS-EPI序列,b值分别取0、700 s/mm^2,在动态增强扫描图像上强化明显的区域作为扩散加权成像图上的感兴趣区,测定肿瘤的ADC值。结果在33例肿瘤中,良性肿瘤为17例,平均ADC值为(1.54±0.35)×10^(-3)mm^2/s,恶性肿瘤共有16例,平均ADC值为(1.45±0.45)×10^(-3)mm^2/s,二者之间无显著性差异(P>0.05)。在33例病例中,共有6例软骨类肿瘤,平均ADC值(1.94±0.51)×10^(-3)mm^2/s;非软骨类肿瘤共有27例,平均ADC值(1.41±0.29)×10^(-3)mm^2/s,二者之间有显著差异(P<0.05)。除1例软骨类肿瘤外,所有软骨类肿瘤的ADC值均大于2.0×10^(-3)mm^2/s。结论以MR动态增强图像来选取DWI图像上肿瘤的感兴趣区(ROI)而测得的ADC值不能区分肌肉骨骼系统肿瘤的良恶性;但是高ADC值(>2.0×10^(-3)mm^2/s)对诊断软骨类肿瘤有一定价值。
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