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中华病理学杂志 1990年第2期19卷 145-146+174页

作者：孟庆海黄志英范秉哲姚一中北京胸部肿瘤研究所

角蛋白(keratin)是广泛存在于各类上皮及其肿瘤细胞内的一种中间丝,它对研究肿瘤的起源、分化、分类及诊断等均具有一定意义[Cell 1982;31:*** In-vest 1985;52:243.]。但有关各组织学类型及亚型肺癌的角蛋白表达,目前尚缺乏全面了解。... 详细信息

角蛋白(keratin)是广泛存在于各类上皮及其肿瘤细胞内的一种中间丝,它对研究肿瘤的起源、分化、分类及诊断等均具有一定意义[Cell 1982;31:*** In-vest 1985;52:243.]。但有关各组织学类型及亚型肺癌的角蛋白表达,目前尚缺乏全面了解。我们对160例支

关键词：肺肿瘤/治疗角蛋白质类/分析支气管肿瘤/诊断

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Cytokeratin expression of apocrine and eccrine poromas with special reference to its expression in cuticular cells

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JOURNAL OF CUTANEOUS PATHOLOGY 2000年第7期27卷 367-373页

作者： Yamamoto, O Hisaoka, M Yasuda, H Kasai, T Hashimoto, H Univ Occupat & Environm Hlth Sch Med Dept Dermatol & Occupat Dermatopathol Yahatanishi Ku Kitakyushu Fukuoka 8078555 Japan Univ Occupat & Environm Hlth Sch Med Dept Pathol & Oncol Yahatanishi Ku Kitakyushu Fukuoka 807 Japan

Background: There are no immunohistochemical studies on cytokeratin (CK) expression in large series of cases of apocrine poroma. In addition, detailed immunohistochemical analysis of cuticular cells, a specific type of constituent cells of poromas, has not been reported. Methods: Using the avidin-biotin method, we compared immunostaining patterns of eleven different anti-CK antibodies in 12 cases of apocrine and 21 cases of eccrine poromas, and normal adult skin. Results: Poroid cells were exclusively positive for CK1/5/10/14,, CK5/8 and CK14, which were expressed in the outer cells of normal dermal sweat ducts. Poroid cells were heterogeneously stained with anti-CK7, CK8/18, CK10/11 and CK19 antibodies, which reacted in the inner cells of dermal ducts and in the secretory cells of sweat glands. The cuticular cells showed constant expression of CK1/5/ 10/14 and CK10/11, and various expression patterns of CK5/8, CK6, CK7, CK14, CK8/18, CK17, and CK19. Conclusions: Based on the keratin immunohistochemistry, the neoplastic cells in eccrine and apocrine poromas are considered to be closely related to the cells of dermal sweat ducts. Also the cuticular cells are considered to occupy an intermediate spectrum between the inner and outer cells of the dermal ducts. Although it is difficult to differentiate apocrine poroma from eccrine poroma by keratin expression patterns alone, the data obtained here can be helpful in differentiation of apocrine poroma from other hair follicle-related neoplasms.

关键词：肢端汗腺瘤外分泌/代谢肢端汗腺瘤外分泌/病理学顶泌腺/化学顶泌腺/病理学外分泌汗腺/化学外分泌汗腺/病理学毛囊/化学毛囊/病理学免疫组织化学角蛋白质类/分析角蛋白质类/生物合成皮肤/化学皮肤/病理学汗腺肿瘤/代谢汗腺肿瘤/病理学青少年成年人老年人老年人 80以上女(雌)性人类男(雄)性中年人

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Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor

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FERTILITY AND STERILITY 1999年第3期72卷 546-548页

作者： Klonisch, T Hombach-Klonisch, S Buchmann, J Fischer, B Bergmann, M Steger, K Univ Halle Wittenberg Fac Med Dept Anat & Cell Biol D-06097 Halle Germany Univ Halle Wittenberg Fac Med Dept Anat & Cell Biol D-4010 Halle Germany Univ Halle Wittenberg Fac Med Dept Pathol D-4010 Halle Germany Univ Giessen Fac Vet Med Inst Vet Anat Giessen Germany

Relaxin-like factor (RLF), a new member of the insulin-like growth factor family, is a reliable marker for normal Leydig cells in the human postpubertal testis (1). Expression of the RLF gene appears to be developmentally regulated, given that only during puberty is RLF expression up-regulated. We recently demonstrated down-regulation of the human RLF gene in testicular Leydig cell tumors indicating dedifferentiation of the Leydig cells within the tumor (2). Ovarian Sertoli-Leydig cell tumors (SLCTs), histologically typed as androblastomas, are rare, potentially malignant sex-cord stromal tumors exhibiting testicular-like structure and differentiation of various degrees. In the present study, we investigated the expression of RLF, 17alpha-hydroxylase, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), Ki-67, and cytokeratin 18 in a human ovarian SLCT of low differentiation.

关键词： 3-羟甾类脱氢酶类/分析细胞分化基因表达免疫组织化学原位杂交胰岛素角蛋白质类/分析 Ki-67抗原/分析卵巢肿瘤/化学卵巢肿瘤/代谢卵巢肿瘤/病理学蛋白质类/分析蛋白质类/遗传学 RNA 信使/分析 Sertoli-Leydig细胞瘤/化学 Sertoli-Leydig细胞瘤/代谢 Sertoli-Leydig细胞瘤/病理学类固醇17-α-羟化酶/分析女(雌)性人类中年人

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SELF-ASSEMBLY OF BOVINE EPIDERMAL KERATIN FILAMENTS INVITRO

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JOURNAL OF MOLECULAR BIOLOGY 1976年第3期108卷 547-567页

作者： STEINERT, PM IDLER, WW ZIMMERMAN, SB NCI DERMATOL BRANCHBETHESDAMD 20014 NIAMDD MOLEC BIOL LABBETHESDAMD 20014

The seven α-keratin polypeptides which comprise the subunits of the in situ epidermal keratin filaments of bovine epidermis polymerize in vitro in dilute salt solution into filaments that have the same structure as the in situ keratin filaments. Most combinations of two or three of the purified polypeptides also polymerize into filaments of the same general structure and these contain the polypeptides in the precise molar ratios of 1:2 or 1:1:1. On the basis of these polypeptide stoichiometries and the characteristic α-type X-ray diffraction pattern by all filaments, it is concluded that the keratin filaments polymerized in vitro and thus the in situ epidermal keratin filaments are comprised of a three-chained unit structure. Turbidometric measurements of the kinetics of filament assembly revealed a biphasic mechanism, involving the initial rate-limiting formation of a hexamer nuclear particle, followed by a more rapid rate of polymerization to filaments. The nuclear particle probably consists of a pair of triple-chained units.

关键词：化学现象化学二硫化物类蹄和爪角蛋白质类/分析角蛋白质类/分离和提纯动力学显微镜检查电子肽类/分析聚合物蛋白质构象 X线衍射动物牛

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Size-dependent in vivo growth potential of adult rat hepatocytes

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AMERICAN JOURNAL OF PATHOLOGY 2001年第1期158卷 97-105页

作者： Katayama, S Tateno, C Asahara, T Yoshizato, K Hiroshima Univ Grad Sch Sci Dept Biol Sci Dev Biol Lab Hiroshima 7398526 Japan Hiroshima Prefectural Inst Ind Sci & Technol Japan Sci & Technol Corp Hiroshima Prefecture Joint Res Project Reg Intens Hiroshima Tissue Regenerat Project Higashihiroshima Japan Hiroshima Univ Sch Med Dept Surg 2 Higashihiroshima 724 Japan

The present study was performed to determine whether hepatocytes show a size-dependent growth in vivo using as a growth assay system, a retrorsine/partial hepatectomy model of dipeptidyl dipeptidase IV-deficient (DPPIV-) mutant Fischer rats. Nearly pure populations of small hepatocytes (SHs) and parenchymal hepatocytes (PHs) were prepared from DPPIV+ rats. The same number of these SHs and PHs was transplanted into the liver of retrorsine-treated and two-thirds partial hepatectomized DPPIV- rats. At 21 days after transplantation, colonies derived from donor hepatocytes were detected as DPPIV+ cells by enzyme histochemistry, SHs were approximately three times more proliferative than PHs (673 +/- 25 cells/colony versus 226 +/- 10 cells/colony, mean +/- SE). SHs mere subfractionated by a fluorescence-activated cell sorter into SH-R2s and SH-R3s. SH-R3s showed a lower extent of granularity and autofluorescence, and a smaller size than SH-R2s that showed characteristics similar to PHs. The growth potential of SH-R3s assayed as above was approximately three times higher than that of SH-R2s (1,101 +/- 46 cells/ colony versus 341 +/- 13 cells). These results indicate that the in vivo growth potential of hepatocytes is heterogeneous and is correlated with their size, and the extent of their granularity and autofluorescence.

关键词：白蛋白类/分析抗原 CD26/遗传学抗原 CD26/代谢细胞计数细胞分裂细胞大小/生理学细胞移植克隆细胞/细胞学肝细胞/细胞学肝细胞/酶学角蛋白质类/分析肝/化学肝/细胞学表型大鼠近交F344 甲胎蛋白类/分析动物女(雌)性男(雄)性大鼠

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Pigmented squamous cell carcinoma

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JOURNAL OF CUTANEOUS PATHOLOGY 2000年第2期27卷 93-95页

作者： Chapman, MS Quitadamo, MJ Perry, AE Dartmouth Hitchcock Med Ctr Dept Pathol Lebanon NH 03756 USA Dartmouth Hitchcock Med Ctr Dept Med Dermatol Sect Lebanon NH 03766 USA

Pigmented squamous cell carcinomas have been reported in the oral and ocular mucosae, but rarely in the skin. We present a case of pigmented squamous cell carcinoma of the forehead and review the current English literature. Pigmented squamous cell carcinoma can be confused with pigmented basal cell carcinomas and melanoma, especially those melanomas associated with pseudoepitheliomatous hyperplasia and should be included in the differential diagnosis of atypical pigmented lesions.

关键词：癌鳞状细胞/化学癌鳞状细胞/病理学细胞分化诊断鉴别额角蛋白质类/分析黑素类/分析黑素细胞/化学黑素细胞/病理学黑色素瘤/病理学黑变病/病理学皮肤肿瘤/化学皮肤肿瘤/病理学人类男(雄)性中年人

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The mind's eye

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AMERICAN JOURNAL OF CLINICAL PATHOLOGY 2001年第5期116卷 635-636页

作者： Asa, SL Cheung, CC Univ Hlth Network Dept Pathol Toronto ON Canada Univ Toronto Dept Lab Med & Pathobiol Toronto ON Canada

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Epithelioid sarcoma arising on the nose of a child: a case report and review of the literature

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JOURNAL OF CUTANEOUS PATHOLOGY 2000年第4期27卷 186-190页

作者： Billings, SB Hood, AF Indiana Univ Sch Med Dept Pathol & Lab Med Indianapolis IN USA

A 4-year-old boy presented with a 6-month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistochemistry the tumor cells were positive for cytokeratin, epithelial membrane antigen, vimentin, and CD34, but negative for S-100, CD31, factor VIII-related antigen, CD68, actin, desmin and myoglobin. Epithelioid sarcoma is an uncommon tumor of uncertain histogenesis that typically arises in the extremities of young adults. Both the age of our patient and the location of his tumor are unusual, emphasizing the spectrum of presentations that may occur with epithelioid sarcoma. Epithelioid sarcoma should be considered in the differential diagnosis of granulomatous diseases and epithelioid tumors of children, even in unusual locations.

关键词：抗原 CD34/分析 CA-15-3抗原/分析诊断鉴别免疫组织化学角蛋白质类/分析肿瘤蛋白质类/分析鼻肉瘤/化学肉瘤/病理学皮肤肿瘤/化学皮肤肿瘤/病理学肿瘤标记生物学/分析波形蛋白/分析儿童学龄前人类男(雄)性

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Cellular origins of ultraviolet radiation-induced corneal tumours in the grey, short-tailed South American opossum (Monodelphis domestica)

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JOURNAL OF COMPARATIVE PATHOLOGY 2000年第2-3期123卷 88-95页

作者： Kusewitt, DF Hubbard, GB Warbritton, AR McLeskey, SW Miska, KB Henkel, RD Robinson, ES Univ New Mexico Dept Cell Biol & Physiol Sch Med Albuquerque NM 87131 USA SW Fdn Biomed Res San Antonio TX 78284 USA Pathol Associates Int Jefferson AR USA Georgetown Univ Washington DC USA Univ New Mexico Dept Biol Albuquerque NM 87131 USA

Corneal tumours were induced in almost 100% of grey, short-tailed South American opossums (Monodelphis domestica) exposed three times weekly to ultraviolet radiation (UVR) for periods of a year or more. Five tumours, representing the morphological spectrum of UVR-induced corneal tumours (two fibrosarcomas, one malignant fibrous histiocytoma, one putative haemangiosarcoma, and one squamous cell carcinoma overlying a sarcoma), were assayed immunohistochemically for reactivity with antibodies against the intermediate filaments vimentin, smooth muscle actin (alpha isoform), muscle-specific actins (alpha and gamma isoforms), desmin and cytokeratin, and with antibodies against the vascular endothelial marker von Willebrand factor. The squamous cell carcinoma was cytokeratin-positive. Other tumours were cytokeratin-negative and vimentin-positive. Three tumours had scattered individual cells and groups of cells immunoreactive with antibodies against smooth muscle actin and muscle-specific actins;two tumours (a fibrosarcoma and the malignant fibrous histiocytoma) had small numbers of desmin-positive cells. The putative haemangiosarcoma contained two populations of neoplastic cells, von Willebrand factor-positive vascular endothelial cells and smooth muscle actin-positive spindle cells. It was concluded (1) that UVR-induced corneal tumours may be composed of cells derived from resident epithelial cells, immigrant vascular endothelial cells, or fibroblast-like cells of unknown origin, and (2) that such tumours may contain more than one neoplastic cell type. (C) 2000 Harcourt Publishers Ltd.

关键词：肌动蛋白类/分析癌鳞状细胞/病因学癌鳞状细胞/代谢癌鳞状细胞/病理学角膜/化学角膜/病理学角膜/辐射效应结蛋白/分析眼肿瘤/病因学眼肿瘤/代谢眼肿瘤/病理学纤维肉瘤/病因学纤维肉瘤/代谢纤维肉瘤/病理学血管肉瘤/病因学血管肉瘤/代谢血管肉瘤/病理学组织细胞瘤良性纤维性/病因学组织细胞瘤良性纤维性/代谢组织细胞瘤良性纤维性/病理学免疫组织化学角蛋白质类/分析肌平滑/化学负鼠辐射损伤实验性/病因学辐射损伤实验性/代谢辐射损伤实验性/病理学波形蛋白/分析 vonWillebrand因子/分析动物女(雌)性男(雄)性

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Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray

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AMERICAN JOURNAL OF PATHOLOGY 2003年第3期162卷 925-932页

作者： Higgins, JPT Shinghal, R Gill, H Reese, JH Terris, M Cohen, RJ Fero, M Pollack, JR van de Rijn, M Brooks, JD Stanford Univ Sch Med Dept Urol Stanford CA 94305 USA Stanford Univ Sch Med Dept Pathol Stanford CA 94305 USA Santa Clara Valley Med Ctr Dept Urol San Jose CA 95128 USA Palo Alto VA Hosp Dept Urol Palo Alto CA USA Univ Western Australia Urol Res Ctr Dept Surg Perth WA 6009 Australia Stanford Univ Sch Med Dept Genet Stanford CA 94305 USA

Renal cell carcinoma comprises several histological types with different clinical behavior. Accurate pathological characterization is important in the clinical management of these tumors. We describe gene expression profiles in 41 renal tumors determined by using DNA microarrays containing 22,648 unique cDNAs representing 17,083 different UniGene Clusters, including 7230 characterized human genes. Differences in the patterns of gene expression among the different tumor types were readily apparent;hierarchical cluster analysis of the tumor samples segregated histologically distinct tumor types solely based on their gene expression patterns. Conventional renal cell carcinomas with clear cells showed a highly distinctive pattern of gene expression. Papillary carcinomas formed a tightly clustered group, as did tumors arising from the distal nephron and the normal kidney samples. Surprisingly, conventional renal cell carcinomas with granular cytoplasm were heterogeneous, and did not resemble any of the conventional carcinomas with clear cytoplasm in their pattern of gene expression. Characterization of renal cell carcinomas based on gene expression patterns provides a revised classification of these tumors and has the potential to supply significant biological and clinical insights.

关键词：腺癌透明细胞/遗传学腺癌透明细胞/病理学腺癌透明细胞/外科学抗原 CD/分析抗原 CD/遗传学癌乳头状/遗传学癌乳头状/病理学癌乳头状/外科学癌肾细胞/遗传学癌肾细胞/病理学癌肾细胞/外科学细胞质颗粒/病理学 DNA指纹法 DNA 互补/遗传学基因表达调控肿瘤角蛋白质类/分析角蛋白质类/遗传学肾肿瘤/分类肾肿瘤/遗传学肾肿瘤/病理学肾肿瘤/外科学多基因族肾切除术肾单位/病理学脑啡肽酶/分析脑啡肽酶/遗传学寡核苷酸序列分析波形蛋白/分析波形蛋白/遗传学人类

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