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中华病理学杂志 1991年第3期20卷 228-228,252页

作者：于顺禄卞昭汉李瑞宗天津医院骨科研究所

肿瘤样钙盐沉着症(tumoral calcinosis)是一种少见的非肿瘤性病变,病因尚不清楚。为引起对本病的重视,我们复习了我院收治的5例肿瘤样钙盐沉着症的临床、X 线及病理特征,现报道如下:一、临床资料及结果例1 男性,41岁,因左大腿上端疼痛20余

关键词：钙质沉着症/病理学

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Calcified left ventricular mass: Unusual clinical, echocardiographic, and computed tomographic findings of primary cardiac osteosarcoma

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MAYO CLINIC PROCEEDINGS 2000年第7期75卷 743-747页

作者： Nowrangi, SK Ammash, NM Edwards, WD Breen, JF Edmonson, JH Mayo Clin & Mayo Fdn Div Cardiovasc Dis & Internal Med Rochester MN 55905 USA Mayo Clin & Mayo Fdn Div Anat Pathol Rochester MN 55905 USA Mayo Clin & Mayo Fdn Dept Diagnost Radiol Rochester MN 55905 USA Mayo Clin & Mayo Fdn Div Med Oncol Rochester MN 55905 USA

Primary cardiac osteosarcomas are rare and usually originate in the left atrium, In contrast, osteosarcomas metastatic to the heart most commonly involve the right cardiac chambers. This case report describes an unusual primary cardiac osteosarcoma, initially observed as a slowly growing, densely calcified mass of the left ventricle with subsequent secondary pulmonary metastasis, Although cardiac tumors may be asymptomatic, this patient had recurrent bouts of ventricular tachyarrhythmia, We describe the clinical, echocardiographic, and radiological observations spanning 6 years and the gross and microscopic features at autopsy.

关键词：钙质沉着症/诊断钙质沉着症/病理学心肌疾病/诊断心肌疾病/病理学诊断鉴别超声心动描记术致命性结局随访研究心脏肿瘤/诊断心脏肿瘤/病理学心室/病理学骨肉瘤/诊断骨肉瘤/病理学体层摄影术 X线计算机人类男(雄)性中年人

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PATHOLOGY OF CEREBRAL EMBOLIZATION CAUSED BY NONTHROMBOTIC AGENTS

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HUMAN PATHOLOGY 1975年第5期6卷 599-610页

作者： GHATAK, NR WAKE FOREST UNIV BOWMAN GRAY SCH MEDDEPT PATHOLWINSTON SALEMNC 27103

Although apparently infrequent, a variety of agents other than thrombotic material are known to cause cerebral embolization, often with serious consequences. The emboli may originate in different parts of the body or may be introduced from outside under diverse circumstances. The pathologic aspects of these individual embolic phenomena are described with particular emphasis on their recognition at autopsy. Adequate autopsy study appears to be the most important source of information for further elucidation of the incidence, mechanism, and sequelae of these heterogeneous embolic lesions of the brain. Such information is essential for clinical evaluation, management, and, more importantly, prevention of some of these potentially serious embolic phenomena.

关键词：动脉硬化/并发症动脉硬化/病理学脑/病理学钙质沉着症/并发症钙质沉着症/病理学栓塞空气/并发症栓塞空气/病理学栓塞脂肪/并发症栓塞脂肪/病理学心内膜炎/并发症心内膜炎/病理学心内膜炎细菌性/并发症心内膜炎细菌性/病理学异物/并发症异物/病理学颅内动脉瘤/病理学颅内栓塞和血栓形成/病因学颅内栓塞和血栓形成/病理学肿瘤/并发症肿瘤/病理学人类

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MORPHOLOGIC OBSERVATIONS ON HEART VALVE PROSTHESES MADE OF FASCIA LATA

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JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 1975年第2期70卷 360-366页

作者： SILVER, MD HUDSON, REB TRIMBLE, AS TORONTO GEN HOSP DEPT PATHOLTORONTOONTARIOCANADA TORONTO GEN HOSP DEPT CARDIOVASC SURGTORONTOONTARIOCANADA UNIV TORONTO TORONTOONTARIOCANADA

A cooperative, international study permitted morphologic observations on 58 fascia lata heart valve prostheses. Thirty-nine had been in position less than a year, the remainder for periods up to 50 months. The fascial cusps, no matter whether free or stent mounted, underwent changes that included death of the original fascia and vacuolar, degenerative changes if a valve had been in situ more than 3 years. Formation of a pseudointima on a cusp's surface caused it to shrink. The rate of progression and severity of the changes varied from prosthesis to prosthesis. Severe cusp shrinkage caused valve incompetence. That seemed particularly likely in mitral and tricuspid prostheses and explains why their use has been abandoned. Clinically, fascia lata aortic valves function satisfactorily for several years. However, their long-term value is still uncertain. Morphologically, the specter of late calcification and other degenerative changes haunt their use until more, from long-term survivors, are available for study.

关键词：主动脉瓣/外科学主动脉瓣关闭不全/病因学钙质沉着症/病理学水肿/病理学心内膜炎细菌性/并发症筋膜/移植阔筋膜/病理学阔筋膜/移植心脏瓣膜/外科学组织学技术二尖瓣/外科学二尖瓣闭锁不全/病因学手术后并发症时间因素移植自体三尖瓣/外科学三尖瓣闭锁不全/病因学人类

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Cerebral ischemic disease and morphometric analyses of carotid plaques

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ANNALS OF VASCULAR SURGERY 1999年第5期13卷 468-474页

作者： van Swijndregt, AD Elbers, HRJ Moll, FL de Letter, J Ackerstaff, RGA Dept Radiol NL-1091 HA Amsterdam Netherlands St Antonius Hosp Dept Pathol Nieuwegein Netherlands St Antonius Hosp Dept Vasc Surg Nieuwegein Netherlands St Antonius Hosp Dept Clin Neurophysiol Nieuwegein Netherlands

Atherosclerotic carotid plaque morphology and especially, intraplaque hemorrhage are assumed to be related to neurological symptoms. Most researchers have only investigated the incidence of intraplaque hemorrhage in symptomatic and asymptomatic patients. In the present study, the amount of intraplaque hemorrhage is determined in carotid endarterectomy specimens from 33 symptomatic and 14 asymptomatic patients that caused >70% luminal stenosis. The plaque components (fibrosis, lipids, intraplaque hemorrhage, calcification, and intraluminal thrombosis) were quantified as a percentage of the total plaque volume. A high incidence of intraplaque hemorrhage was found in both the symptomatic (94%, 31/33) and asymptomatic (71%, 10/14) patients. The amount of intraplaque hemorrhage was very small within the plaques of the symptomatic (0.39% +/- 0.70%) and asymptomatic (0.37% +/- 1.12%) patients. The plaques of the symptomatic patients contained more fibrosis than lipids (45.62% +/- 14.99% and 20.45% +/- 21.45%, respectively), as did the plaques of the asymptomatic patients (42.51% +/- 15.28% and 15.46% +/- 15.22%, respectively). Finally, intraluminal thrombosis and calcification were rare. We conclude that the amount of intraplaque hemorrhage was very small and therefore question its direct role in the development of neurological symptoms. In general, the "unstable" plaque contained more fibrosis than lipids.

关键词：血管造影术动脉硬化/并发症动脉硬化/病理学动脉硬化/外科学盲/病因学脑缺血/病因学钙质沉着症/病理学颈动脉血栓形成/病理学颈动脉狭窄/并发症颈动脉狭窄/病理学颈动脉狭窄/外科学脑血管障碍/病因学颈动脉内膜切除术纤维化出血/病理学图像处理计算机辅助脑缺血发作短暂性/病因学脂类超声检查多普勒双功能成年人老年人女(雌)性人类男(雄)性中年人

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Pseudoxanthoma elasticum and calcinosis cutis

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JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2000年第2期43卷 312-315页

作者： Buka, R Wei, HC Sapadin, A Mauch, J Lebwohl, M Rudikoff, D Mt Sinai Med Ctr Dept Dermatol New York NY 10029 USA

A 42-year-old white woman presented with clinical and histologic manifestations of both calcinosis cutis and pseudoxanthoma elasticum: discrete milia-like calcifications at the anterior aspect of the neck, a funduscopic examination with classic eye findings, peripheral vascular disease, and a mottled appearance of the skin at the axillae, groin, and lateral aspects of the neck. A younger sibling had similar skin lesions and deteriorating visual acuity. The patient was normocalcemic and normophosphatemic. This case may represent the coincidental occurrence of two rare entities in the same person or may be suggestive of a pattern of dystrophic calcification associated with pseudoxanthoma elasticum.

关键词：钙质沉着症/并发症钙质沉着症/病理学假黄瘤弹性/并发症假黄瘤弹性/病理学皮肤疾病/并发症皮肤疾病/病理学成年人女(雌)性人类

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BRAIN CALCIFICATION IN A CASE OF ACUTE LYMPHOBLASTIC LEUKEMIA

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JOURNAL OF THE NEUROLOGICAL SCIENCES 1975年第2期25卷 145-152页

作者： MICHOTTE, Y SMEYERSVERBEKE, J EBINGER, G MAURUS, R PELSMAEKERS, J LOWENTHAL, A MASSART, DL VRIJE UNIV BRUSSEL FARM INST PAARDEN STR 67 B-1640 ST GENESIUS RODE BELGIUM VRIJE UNIV BRUSSEL LAB FYSIOPATHOL ZENUWSTELSEL EVERS STR 2 B-1000 BRUSSELS BELGIUM HOP ST PIERRE PEDIAT CLIN BRUSSELS BELGIUM CEN B-2400 MOL BELGIUM

Cortical calcifications, ween on X-ray in the brain of achild suffering from leukaemia, were submitted to morphological and chemical analysis. The morphology was studied by a combination of low teperature ashing and microscanning. The calcification principally affected axons and capillary walls and consisted of spherules amalgamated into hollow cylinders. The results of chemical analysis of the calcified material were compared and structure of both types of calcification were similar, but the Mn concentration washigher in case of Fahr's disease. X-ray diffraction showed that the calcification consisted of amorphous calcium phosphate and acid calcium orthophosphate, most probably precursors of hydroxyapatite..

关键词：脑/超微结构脑化学脑疾病/病因学脑疾病/病理学钙质沉着症/病因学钙质沉着症/病理学钙铜铁白血病淋巴样/并发症白血病淋巴样/病理学白血病淋巴样/放射疗法镁锰显微镜检查电子扫描磷放射疗法/副作用分光光度法原子分光光度法红外线 X线衍射锌儿童人类男(雄)性

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Calcified plaque cross-sectional area in human arteries: Correlation between intravascular ultrasound and undecalcified histology

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AMERICAN HEART JOURNAL 1999年第3期137卷 482-488页

作者： Kostamaa, H Donovan, J Kasaoka, S Tobis, J Fitzpatrick, L UCI Med Ctr Div Cardiol Orange CA 92868 USA Univ Calif Irvine Mayo Clin & Mayo Fdn Div Endocrinol & Metab Dept Med Orange CA 92868 USA

Background The purpose of this investigation was to quantify the amount of intralesional calcium defected by intravascular ultrasound (IVUS) compared. with undecalcified histology in human arteries. This method preserves intralesional calcium and reduces sectioning artifacts;thereby providing an accurate measure of calcium plaque morphology. Methods and Results Ten arterial segments (5 coronary, 5 iliac) were obtained at autopsy. IVUS imaging was performed with,a 4.9F catheter at an automated pullback rate of 1.0 mm/s. The undecalcified arteries were dehydrated in ascending alcohol and polymerized in glycol methylmethacrylate. The arteries were cut into 200-mu m sections with an Isomet low-speed saw and stained with Goldner's trichrome. The lumen cross-sectional area, the calcium plaque cross-sectional area, the calcium plaque depth, length, and angle of arc,of calcified plaque were measured from the IVUS images and histologic sections. In 24 selected cross sections, there were 38 separate calcium plaques. An independent observer correctly identified;34 of 38 calcified plaques for a sensitivity of 89% and specificity of 97%. The total mean calcified plaque cross-sectional area measured from histology was 4.6 +/- 4.1 mm(2) compared with 2.8 +/- 2.3 mm(2) by IVUS (P=.002), Plaque depth measured by histology was 1.2 +/- 0.4 mm verses 0.7 +/- 0.2 mm by IVUS (P =.001). The length of calcium plaques measured by histology was 3.6 +/- 1.78 mm versus 3.6 +/-: 1.5 mm for IVUS (r = 0.79). Conclusions IVUS accurately depicts circumferential calcified lesions with high sensitivity (89%) and specificity (97%). However, IVUS underestimates the total calcified plaque cross-sectional area by 39%. This is mainly because of the inability of the ultrasound to penetrate intralesional calcium, which leads to an underestimation of the depth of calcium by 45%.

关键词：解剖学横断面动脉硬化/病理学动脉硬化/超声检查伪迹偶氮化合物/诊断应用尸体钙质沉着症/病理学钙质沉着症/超声检查钙着色剂/诊断应用曙红黄-(YS)/诊断应用环氧化合物乙醇固定剂髂动脉/病理学髂动脉/超声检查图像处理计算机辅助甲基丙烯酸盐甲基绿/诊断应用显微切片术观察者偏差敏感性与特异性超声检查介入性成年人老年人女(雌)性人类男(雄)性中年人

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INTRACEREBRAL CALCIFICATIONS APPEARING DURING COURSE OF ACUTE LYMPHOCYTIC LEUKEMIA TREATED WITH METHOTREXATE AND X-RAYS

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CANCER 1975年第2期35卷 319-325页

作者： FLAMENTDURAND, J KETELBANTBALASSE, P MAURUS, R REGNIER, R SPEHL, M UNIV LIBRE BRUSSELS DEPT PATHOLBRUSSELSBELGIUM UNIV LIBRE BRUSSELS DEPT CLIN PEDIATBRUSSELSBELGIUM UNIV LIBRE BRUSSELS DEPT PEDIAT RADIOLBRUSSELSBELGIUM UNIV LIBRE BRUSSELS DEPT RADIOTHERAPYBRUSSELSBELGIUM

The authors present the case of a child aged 7 years who suffered from relapsing acute lymphocytic leukemia. Treatment consisting mainly of oral and intrathecal methotrexate and x-ray therapy produced remission of the hematologic symptoms. Three years after the onset of the leukemia, mental deterioration gradually appeared. Radiography of the skull revealed diffuse bilateral calcium deposits in both cerebral and cerebellar hemispheres. Four years after the onset of the disease, a hematologic relapse occurred. Behavioral disorders became more severe and the child died after a period of seizures and unconsciousness. The main pathologic data obtained by the study of a brain biopsy and after a complete postmortem examination consisted of calcifications located bilaterally in the cerebral and cerebellar cortex. No signs of leukemia were present. Cerebral calcification is an extremely rare complication in the course of the therapy of lymphocytic leukemia. Its possible causes are discussed.

关键词：投药口服脑疾病/化学诱导脑疾病/诊断显像脑疾病/病因学脑疾病/病理学钙质沉着症/化学诱导钙质沉着症/诊断显像钙质沉着症/病因学钙质沉着症/病理学小脑/病理学大脑皮质/病理学注射脊髓白血病淋巴样/放射疗法白血病淋巴样/治疗甲氨蝶呤/投药和剂量甲氨蝶呤/副作用甲氨蝶呤/治疗应用放射摄影术放射疗法/副作用儿童人类男(雄)性

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MASSIVE CALCIFICATION OF MYOCARDIUM

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ANGIOLOGY 1975年第10期26卷 734-739页

作者： MACIEIRACOELHO, E RICARDO, JA FALEIRO, LL DACOSTA, JC HOSP SANTA MARIA DEPT CARDIOLLISBONPORTUGAL HOSP STA MARIA SERV TERAPEUTICA MEDAV EGAS MONIZLISBOAPORTUGAL

A case of dystrophic calcification of the myocardium is reported. The clinical, fluoroscopic hemodynamic and angiographic findings are described; they correlate well with the lesions discovered at surgery. In this case, the diagnosis was originally suspected because of the calcification noted during fluoroscopy. The histopathology (biopsy specimen) of the endocardium and myocardium is described, and the pathogenesis is discussed (30 references).

关键词：钙质沉着症/病理学钙质沉着症/外科学心肌疾病/病理学心肌疾病/外科学成年人人类男(雄)性

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