BACKGROUND: Radiation therapy is widely used to treat tumor of brain; however, irradiation of radiation into eye tissues may easily cause ischemia and hypoxia in retina and optic nerve tissue so as to induce radiation...
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BACKGROUND: Radiation therapy is widely used to treat tumor of brain; however, irradiation of radiation into eye tissues may easily cause ischemia and hypoxia in retina and optic nerve tissue so as to induce radiation optic *** is a specific antagonist of opiate receptor, and it can change injured effect of f3 -***: To observe the axoplasmic transport of optic nerve at various phases after radiation injury so as to investigate the mechanism and regularity of optic nerve injury; meanwhile, to verify the therapeutic effects of naloxone on radiation optic ***: Randomized controlled animal ***: Medical College of Qingdao University, Changzhi Medical ***: A total of 40 healthy adult New Zealand rabbits, weighing 2 - 2.5 kg, of either gender, were checked by using slit lamp and ophthalmoscop before radiation in order to exclude eye ***-7000 vertical kilocurie ^60Co therapeutic machine was made in Yantai, China; in addition, naloxone was provided by Beijing Sihuan Pharmaceutical ***: The experiment was carried out in the Animal Experimental Laboratory, Medical College of Qingdao University from January 2005 to December *** experimental rabbits were randomly divided into radiation group (n =16), treatment group (n =16), blank control group (n=4) and injured control group (n=4).Except blank control group, rabbits in other three groups were irradiated in as the center of optic chiasma including the area of optic nerve by using ^60Co therapeutic *** source was 85 cm away from head, and the size of operative field was 5 cm×5 *** radiation was performed once a day with the dosage of 3 Gy for 8 days in *** total dosage was 24 *** radioactive dosage reached 24 Gy, 2 mg/kg naloxone was dropped into ear vein of rabbits in the treatment group once a day for 10 days in *** in the injured control group were only irradiated but not given any ***
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