Results of estrogenic treatment in 29 cases with a syndrome of rudimentary ovary, some followed up for over 6 years, were discussed. Estrogens produced rapid reactions in a definite order: uterine cervix, vaginal and ...
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Results of estrogenic treatment in 29 cases with a syndrome of rudimentary ovary, some followed up for over 6 years, were discussed. Estrogens produced rapid reactions in a definite order: uterine cervix, vaginal and urethral mucosae, vulva, mammary gland;later there were changes in skin, height, body hair and mental reactions and finally in the appearance of menstruation. Suspension of treatment caused immediate relapse so that implantation of pellets of estradiol was recommended since they retained their activity for as long as 2 years and could be replaced when exhausted. Treatment by mouth with uniform doses of estrogens produced a less marked response in the genital organs, especially in the endometrium, and the dose had to be increased after several months or years in order to maintain the level of response. Several patients suffered from digestive intolerance to estrogens which did not occur in those treated by pellet implantation.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a deadly outcome. AD is the leading cause of senile dementia and although the pathogenesis of this disorder is not known, various hypothese...
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a deadly outcome. AD is the leading cause of senile dementia and although the pathogenesis of this disorder is not known, various hypotheses have been developed based on experimental data accumulated since the initial description of this disease by Alois Alzheimer about 90 years ago. Most approaches to explain the pathogenesis of AD focus on its two histopathological hallmarks, the amyloid beta protein- (A beta-) loaded senile plaques and the neurofibrillary tangles, which consist of the filament protein tau. Various lines of genetic evidence support a central role of A beta in the pathogenesis of AD and an increasing number of studies show that oxidation reactions occur in AD and that A beta may be one molecular link between oxidative stress and AD-associated neuronal cell death. A beta itself can be neurotoxic and can induce oxidative stress in cultivated neurons. A beta is, therefore, one player in the concert of oxidative reactions that challenge neurons besides inflammatory reactions which are also associated with the AD pathology. Consequently, antioxidant approaches for the prevention and therapy of AD are of central interest. Experimental as well as clinical data show that lipophilic antioxidants, such as vitamin E and estrogens, are neuroprotective and may help patients suffering from AD. While an additional intensive elucidation of the cellular and molecular events of neuronal cell death in AD will, ultimately, lead to novel drug targets, various antioxidants are already available for a further exploitation of their preventive and therapeutic potential. (C) 1998 Elsevier Science Ltd. All rights reserved.
1.1. In view of the increasing popularity of artificial suppression of lactation, we have presented a comparative study of 800 cases, illustrating the effects of various endocrines on the market.2.2. Eleven criteria f...
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1.1. In view of the increasing popularity of artificial suppression of lactation, we have presented a comparative study of 800 cases, illustrating the effects of various endocrines on the market.
2.2. Eleven criteria for the ideal endocrine for inhibition of lactation are listed.
3.3. Eight hundred cases were followed during the five days post partum and some by questionnaires given to patients and returned to the hospital three to four weeks post partum.
4.4. Four tables show the effects of the various products on the suppression of lactation, breast engorgement, vaginal (withdrawal) bleeding, and vaginal discharge.
5.5. A brief review of the pertinent literature is presented.
6.6. Some explanation of the possible modus operandi of the suppression of lactation is offered.
7.7. We conclude that ethyl dimethyl allenolic acid (Vallestril), 20 mg. daily for four to five days post partum, is effective in the suppression of lactation.
8.8. We feel that these preliminary results warrant further studies to confirm our present findings.
In 6 female hypo-ovarian dwarfs with web neck, cubitus valgus and increased urinary gonadotropins ("Turner''s syndrome") estrogen produced secondary sex characteristics. Although no evidence of hypo-...
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In 6 female hypo-ovarian dwarfs with web neck, cubitus valgus and increased urinary gonadotropins ("Turner''s syndrome") estrogen produced secondary sex characteristics. Although no evidence of hypo-thyroidism was produced, desiccated thyroid and methyl testosterone admns. were accompanied by growth in 4 patients. In 2, growth started before therapy. Although epiphyseal closure was delayed, estrogens did not appear to accelerate it.
1.1. A method of approach to evaluation of the amenorrheic patient with emphasis on the importance of thinking in terms of physiologic processes in arriving at a differential diagnosis of cause is presented.2.2. Gener...
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1.1. A method of approach to evaluation of the amenorrheic patient with emphasis on the importance of thinking in terms of physiologic processes in arriving at a differential diagnosis of cause is presented.
2.2. General measures, indications for therapy, and specific hormonal therapy which has been successfully employed in functional amenorrhea are discussed.
3.3. Results of clinical observations in 328 courses of therapy administered to 123 patients with functional amenorrhea employing either (a) anhydro-hydroxyprogesterone—10 mg., (b) progesterone—30 mg., or (c) a combination of estrogenic substances—1 mg. and progesterone—30 mg., by ingestion, three times daily for 5 consecutive days are compared. These preparations were found to be equally effective by ingestion in the dosage used, and withdrawal bleeding followed therapy in (a) 90.9 per cent, (b) 90.45 per cent, and (c) 94.1 per cent of instances.
4.4. Simultaneous oral administration of estrogen and progesterone proved slightly superior to progesterone alone but was not sufficient in the dosage used to take the place of estrogen priming in those patients with inadequate intrinsic estrogens.
5.5. It is believed that best results in management of functional amenorrhea are obtained by cyclic administration of estrogen and progesterone in a manner which closely simulates the normal physiologic process of the ovulatory cycle.
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