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Total-body bone mineral content in non-corticosteroid-treated postpubertal females with juvenile rheumatoid arthritis - Frequency of osteopenia and contributing factors

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ARTHRITIS AND RHEUMATISM 2000年第3期43卷 531-540页

作者： Henderson, CJ Specker, BL Georgia State Univ Dept Nutr Atlanta GA 30303 USA S Dakota State Univ Brookings SD 57007 USA Childrens Hosp Med Ctr Cincinnati OH 45229 USA Eli Lilly & Co Indianapolis IN 46285 USA

Objective, To determine the extent of low total-body bone mineral content (BMC) in non-corticosteroid-treated white postpubertal females with juvenile rheumatoid arthritis (JRA) compared with healthy age- and race-matched female controls, and to identify variables that significantly contribute to total-body BMC, Methods. Thirty-six females with definite JRA who had never received corticosteroids and 51 healthy female controls were evaluated, All subjects had had their first menstrual period at least 2 years prior to enrollment. Total-body BMC, lumbar spine bone mineral density, and body composition were determined by dual x-ray absorptiometry, Total-body BMC Z-scores were calculated for JRA patients using data from controls. JRA patients were dichotomized into those with "normal" bone mass (total-body BMC at or above the mean or no more than 1 SD below the mean) and those with "low" bone mass (total-body BMC more than 1 SD below the mean). Comparisons of anthropometric measurements, laboratory measurements of bone metabolism, disease activity, dietary intake, and physical activity were performed, Stepwise logistic regression was utilized to determine the presence or absence of low total-body BMC and to identify associated contributing factors, Results, Total-body BMC was 4.5% lower in JRA patients than in controls (mean +/- SD 2,050 +/- 379 gm versus 2,143 +/- 308 gm;P = 0.21), Twenty-five of 36 patients (69.4%) had "normal" and 11 of 36 (30.6%) had "low" total-body BMC, Comparison of JRA patients with "normal" versus those with "low" total-body BMC revealed significant differences in disease characteristics, anthropometric and physical development characteristics, laboratory measures of bone mineralization, and dietary intake, The final regression model contained only lean mass (P = 0.01), which accounted for 76.3% of the variance in total-body BMC, The odds ratio for lean mass was 0.4451 (95% confidence interval 0.2374-0.8348). Conclusion,ln this study, similar to

关键词：肾上腺皮质激素类/治疗应用人体测量术关节炎幼年型类风湿/药物疗法骨密度骨疾病代谢性/流行病学骨和骨组织/代谢发病率 Logistic模型腰椎/化学青春期/生理学青少年女(雌)性人类

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ASCORBIC-ACID AND EDTA TREATMENT OF LEAD TOXICITY IN RATS

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LIFE SCIENCES 1979年第5期24卷 433-438页

作者： GOYER, RA CHERIAN, MG Department of Pathology Health Sciences Centre University of Western Ontario London Ontario N6A 5C1 Canada

Ascorbic acid given orally to Pb-exposed rats has similar chelating properties as equimolar amounts of parenterally administered EDTA. Ascorbic acid in combination with EDTA is more than twice as effective as either c... 详细信息

关键词：氨基酮戊酸/尿抗坏血酸/治疗应用骨和骨组织/代谢药物疗法联合依地酸/治疗应用铅/代谢铅/尿铅中毒/药物疗法铅中毒/代谢时间因素组织分布动物男(雄)性大鼠

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Bone density and bone metabolism are normal after long-term gluten-free diet in young celiac patients

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AMERICAN JOURNAL OF GASTROENTEROLOGY 1999年第2期94卷 398-403页

作者： Mora, S Barera, G Beccio, S Proverbio, MC Weber, C Bianchi, C Chiumello, G Univ Milan San Raffaele Sci Inst Dept Pediat Lab Pediat Endocrinol I-20132 Milan Italy

Objectives: Osteoporosis and alterations of bone metabolism are frequent complications of celiac disease, We evaluated the impact of long-term gluten-free diet (GFD) initiated during childhood and adolescence on bone mineralization and bone metabolism. Methods: We studied 30 celiac patients on GFD for greater than or equal to 5 yr, The mean age at diagnosis was 11.4 +/- 5.0 yr, and the mean duration of GFD was 10.7 +/- 4.3 yr, Results were compared with those obtained in 240 healthy controls. Bone mineral density (BMD) was measured in the lumbar spine and in the whole skeleton by dual-energy x-ray absorptiometry. Serum levels of bone-specific alkaline phosphatase (BALP) and N-terminal propeptide of type I procollagen (PINP) were measured as bone formation indices, and urine levels of N-telopeptide of type I collagen (NTx) as bone resorption index, Results: BMD measurements of celiac patients (lumbar spine: 1.131 +/- 0.121 g/cm(2);total body: 1.145 +/- 0.184 g/cm(2)) did not differ from those of control subjects (lumbar spine: 1.131 a 0.184 g/cm(2);total body: 1.159 +/- 0.118 g/cm(2)), The levels of BALP, PINP, and NTx of celiac patients did not differ from those of controls. Patients who started GFD before puberty had BMD and bone metabolism measurements comparable to those of patients who started GFD during puberty. Conclusions: Our data show that long-term dietary treatment ensures normal mineralization and bone turnover. (Am J Gastroenterol 1999;94:398-403. (C) 1999 by Am. Cell. of Gastroenterology).

关键词：骨密度/生理学骨重建/生理学骨和骨组织/代谢病例对照研究乳糜泻/并发症乳糜泻/膳食疗法乳糜泻/代谢谷蛋白腰椎/放射摄影术骨质疏松/病因学时间因素成年人女(雌)性人类男(雄)性

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STUDIES ON CALCIFEROL METABOLISM .11. METABOLISM OF 25-HYDROXY-VITAMIN-D3 BY CHICKEN EMBRYO

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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1975年第2期167卷 769-773页

作者： BISHOP, JE NORMAN, AW UNIV CALIF DEPT BIOCHEMRIVERSIDECA 92502

It is known that after birth of a vertebrate there is a requirement for the metabolism of Vitamin D3 (cholecalciferol) to 1,25-(OH)2 -Vitamin D3 to produce the hormonally active form essential for calcium homeostasis. However it is not known whether the enzymatic capability to produce 1,25-(OH)2 -D3 only appears after birth or whether it is generated in the embryo. Presented in this paper are results of studies designed to measure the production and localization of 1,25-(OH)2 -D3 in the embryo. It was found that the renal enzyme, 25-OH-cholecalciferol-1-hydroxylase, which is capable of producing 1,25-(OH)2 -D3 , is present as early as day 9 of incubation (12 days before hatch) in White Leghorn chicks. Further, the enzyme activity increases 6-fold to a maximal level which occurs on the day of hatching. 1,25-(OH)2 -D3 was shown to be produced in vivo at day 17 and was found then in low levels in the embryonic intestine and kidney. Thus we have shown that 1,25-(OH)2 -D3 is made by embryonic chick kidneys and is found in low levels in embryonic chick intestine and kidney significantly before hatch.

关键词：骨和骨组织/代谢脑/代谢色谱法凝胶二羟胆钙化醇类/生物合成骨化醇类/代谢羟基胆骨化醇类/代谢肠黏膜/代谢肾/酶学肝/代谢混合功能氧化酶类/代谢器官特异性时间因素维生素D缺乏/酶学动物鸡胚

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INVITRO STUDIES ON COLLAGEN-METABOLISM IN METAPHYSEAL RAT BONE .C. EFFECT OF ESTRADIOL-17BETA- IN HYPOPHYSECTOMIZED AND IN THYRO-PARATHYROIDECTOMIZED ANIMALS

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ACTA ENDOCRINOLOGICA 1975年第4期80卷 795-800页

作者： LANGELAND, N TEIG, V RIKS HOSP OSLO INST SURG RES OSLO NORWAY

Oestradiol-17 beta has been administered to hypophysectomized/castrated and to thyro-parathyroidectomized/castrated young mature female rats. Treatment with oestradiol-17 beta 5 mug/day per animal, was continued for 3 weeks. Bone pieces from tibia/femur metaphyses were incubated in vitro for 3 h in order to establish the bone collagen synthesis and resorption rates. The results were compared to results from a previous study on castrated female rats with intact hypophysis, thyroid and parathyroid glands. Bone from the thyro-parathyroidectomized/castrated rats treated with oestradiol-17 beta had a significantly reduced collagen resorption rate in vitro as compared to their paired controls. This is a result consistent with that of castrated female rats with intact thyroid and parathyroid glands treated with oestradiol. Oestradiol-17 beta had no detectable effect upon collagen metabolism in the hypophysectomized/castrated rats. It is concluded that the effect of oestradiol on bone resorption is not exerted via the parathyroid glands or parathyroid hormone. The possibility that oestrogens may act on bone via the hypophysis is discussed.

关键词：骨质吸收/药物作用骨和骨组织/代谢阉割胶原/生物合成胶原/代谢抑制化学性雌二醇/药理学股骨/代谢垂体切除术甲状旁腺/生理学垂体/生理学胫骨/代谢时间因素动物女(雌)性大鼠

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MECHANISMS IN SKELETAL ACCUMULATION OF IONS

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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1953年第1期43卷 118-126页

作者： MACDONALD, NS NUSBAUM, RE EZMIRLIAN, F BARBERA, RC SPAIN, P ROUNDS, DE From the School of Medicine University of California at Los Angeles Los Angeles California USA

The deposition of Sr and Pb in the femurs of rats as a function of parenteral dosage was studied. A single injn. was admd., and the content of metal ion was detd. after 24 hrs. Dosages ranged from 0.10 to 75.00 mg. of Sr++/200 g. of body wt. and from 0.03 to 6.00 mg./200 g. of body wt. in the case of Pb++. The uptake indicated that at least 2 modes of accumulation occurred. The dominant process at low dosages was descr. satisfactorily by an equation of the same form as the Langmuir gas adsorption isotherm. However, an abrupt discontinuity in the graph of the data appeared as the dosage was increased. This departure from linearity was interpreted as the point where saturation of the initial mode of deposition was attained. The values of these saturation levels for Sr and Pb were 125 and 60 p.p.m., respectively. It was estimated that if the 1st stage saturation were the result of adsorption or ionic exchange at surfaces of bone salt crystals, the avg. burden would be approx. 32 atoms of Sr per crystal and 6 per crystal in the case of Pb. However, the combining power of the sulfate present in the organic matrix of bone could equally well account for the binding of the saturation levels of Sr and Pb.

关键词：骨和骨组织/代谢铅锶

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BONE-MINERAL CONTENT IN HEREDITARY POLYCYSTIC OSTEODYSPLASIA ASSOCIATED WITH PROGRESSIVE DEMENTIA

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ACTA RADIOLOGICA-DIAGNOSIS 1975年第4期16卷 385-392页

作者： HAKOLA, HPA KARJALAINEN, P NIUVANNIEMI HOSP KUOPIOFINLAND UNIV KUOPIO CENT HOSPSF-70210 KUOPIOFINLAND

Measurements of the bone mineral content were made in five patients with a disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia. Decreased bone mineral density (g/cm3) was observed not only in the region of cysts in the distal radius but also in the diaphyses of radius and ulna. The 85Sr vertebral uptake was low in the youngest patient, normal in two and raised in another two. The observations were compatible with the hypothesis of a general metabolic disorder of the bone.

关键词：骨囊肿/并发症骨囊肿/遗传学骨囊肿/代谢骨疾病发育性/并发症骨疾病发育性/遗传学骨疾病发育性/代谢骨和骨组织/代谢手/放射摄影术矿物质/代谢锶放射性同位素/诊断应用综合征成年人女(雌)性人类男(雄)性

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SYNTHESIS OF 24S AND 24R-HYDROXY-[24-H-3]VITAMIN-D3 AND THEIR METABOLISM IN RACHITIC RATS

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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1976年第2期177卷 615-621页

作者： TANAKA, Y DELUCA, HF AKAIWA, A MORISAKI, M IKEKAWA, N TOKYO INST TECHNOL CHEM NAT PROD LAB TOKYO JAPAN

An epimeric mixture of 24-hydroxy-[24-3H]vitamin D3 was synthesized by the reduction of 24-ketovitamin D3 by sodium borotritide. The epimeric mixture was converted to the trimethylsilylether derivatives and subjected to high-pressure liquid chromatography using silica gel columns to separate the 24-hydroxy-[24-3H]vitamin D3 isomers. The 24R-hydroxy-[24-3H]vitamin D3 induced calcification in rachitic rats while the 24S-hydroxy-[24-3H]vitamin D3 had little or no such activity. As both isomers of 24-hydroxyvitamin D3 are metabolized to 24,25-dihydroxyvitamin D3, it appears that the 24-hydroxyvitamin D3-25-hydroxylase does not discriminate between the isomers. Only the R-isomer of 24-hydroxyvitamin D3 is metabolized to 1,24-dihydroxyvitamin D3, although only trace amounts of this compound were found 2 days after the administration of 24-hydroxyvitamin D3. The striking difference in the metabolism of the isomers is the high selectivity of the 1-hydroxylase for the R-isomer. It is suggested that the high specificity of biological activity for the R-isomer of 24-hydroxyvitamin D3 is because of the specificity of the 1-hydroxylation of 24,25-dihydroxyvitamin D3 for the R configuration.

关键词：骨和骨组织/代谢羟基胆骨化醇类/化学合成羟基胆骨化醇类/代谢肠黏膜/代谢肾/代谢动力学肝/代谢质谱分析法器官特异性佝偻病/代谢动物男(雄)性大鼠

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Osteobiology, strain, and microgravity: Part I. Studies at the cellular level

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CALCIFIED TISSUE INTERNATIONAL 2000年第1期67卷 2-9页

作者： Marie, PJ Jones, D Vico, L Zallone, A Hinsenkamp, M Cancedda, R Ctr Biotecnol Avanzate IST I-16132 Genoa Italy Lariboisiere Hosp INSERM U349 Paris France Univ Marburg Dept Expt Orthopaed & Biomech Marburg Germany Fac Med LBBTO INSERM E9901 St Etienne France Univ Bari Sch Med Inst Human Anat I-70121 Bari Italy Free Univ Brussels Erasme Hosp Dept Orthopaed Surg B-1050 Brussels Belgium Univ Genoa Dipartimento Oncol Biol & Genet Genoa Italy

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Bone health: the role of micronutrients

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BRITISH MEDICAL BULLETIN 1999年第3期55卷 619-633页

作者： New, SA Univ Surrey Sch Biol Sci Ctr Nutr & Food Safety Guildford GU2 5XH Surrey England

Development and maintenance of skeletal health is essential since the resultant effect of poor bone health is an increased risk of osteoporotic fracture. Osteoporosis is currently a major public health problem and with predicted demographic changes, its future health and economic impact is likely to be phenomenal. Adult bone health is predominantly governed by two factors: (i) maximum attainment of peak bone mass;and (ii) rate of bone loss which occurs with ageing. Both aspects are determined by a combination of endogenous and exogenous factors and, although genetic influences are believed to account for up to three-quarters of the variation in bone mass, there is still room for the modifiable factors (including nutrition) to play an important role. There is now good evidence to show that calcium is important not only to peak bone mass development but also in reducing bone loss in women who are greater than 5 years postmenopause. Vitamin D and calcium land possibly vitamin K) are vital to fracture prevention in the elderly. Our knowledge of the influence of other micronutrients on bone health remains limited and further research is required to establish the essential ingredients for optimum bone health.

关键词：衰老/代谢骨发育/生理学骨和骨组织/代谢微量营养系/代谢骨质疏松绝经后/代谢骨质疏松绝经后/预防和控制成年人女(雌)性人类

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