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检索条件"主题词=鸟苷二磷酸/药理学"
15 条 记 录,以下是1-10 订阅
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Direct interaction of Rab4 with syntaxin 4
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JOURNAL OF BIOLOGICAL CHEMISTRY 2001年 第7期276卷 5265-5273页
作者: Li, L Omata, W Kojima, I Shibata, H Gunma Univ Inst Mol & Cellular Regulat Dept Cell Biol Maebashi Gumma 3718512 Japan
In the present study, we examined the possible interaction between Rab4 and syntaxin 4, both having been implicated in insulin-induced GLUT4 translocation. Rab4 and syntaxin 4 were coimmunoprecipitated from the lysate... 详细信息
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The coenzyme B12 analog 5′-deoxyadenosylcobinamide-GDP supports catalysis by methylmalonyl-CoA mutase in the absence of trans-ligand coordination
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JOURNAL OF BIOLOGICAL CHEMISTRY 2001年 第2期276卷 1015-1019页
作者: Chowdhury, S Thomas, MG Escalante-Semerena, JC Banerjee, R Univ Nebraska Dept Biochem Lincoln NE 68588 USA Univ Wisconsin Dept Bacteriol Madison WI 53706 USA
Methylmalonyl-CoA mutase is an 5'-adenosylcobalamin (AdoCbl)-dependent enzyme that catalyzes the rearrangement of methylmalonyl-CoA to succinyl-CoA The crystal structure of this protein revealed that binding of th... 详细信息
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Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2000年 第9期97卷 4654-4659页
作者: Ambruso, DR Knall, C Abell, AN Panepinto, J Kurkchubasche, A Thurman, G Gonzalez-Aller, C Hiester, A deBoer, M Harbeck, RJ Oyer, R Johnson, GL Roos, D Bonfils Blood Ctr Denver CO 80230 USA Univ Colorado Hlth Sci Ctr Dept Pediat Denver CO 80262 USA Univ Colorado Hlth Sci Ctr Dept Pharmacol Denver CO 80262 USA Rhode Isl Hosp Dept Pediat Hematol Oncol Providence RI 02903 USA Rhode Isl Hosp Dept Surg Providence RI 02903 USA Univ Amsterdam Acad Med Ctr Expt & Clin Immunol Lab NL-1105 AZ Amsterdam Netherlands Netherlands Blood Transfus Serv Cent Lab Amsterdam Netherlands Natl Jewish Med & Res Ctr Clin Labs Denver CO 80206 USA
A 5-week-old male infant presented with severe bacterial infections and poor wound healing, suggesting a neutrophil defect. Neutrophils from this patient exhibited decreased chemotaxis. polarization, azurophilic granu... 详细信息
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Histamine suppresses non-NMDA excitatory synaptic currents in rat supraoptic nucleus neurons
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JOURNAL OF NEUROPHYSIOLOGY 2000年 第5期83卷 2616-2625页
作者: Li, ZH Hatton, GI Univ Calif Riverside Dept Neurosci Riverside CA 92521 USA
Whole cell patch-clamp recordings were obtained from supraoptic neurons to investigate the effects of histamine on excitatory postsynaptic currents evoked by electrical stimulation of areas around the posterior suprao... 详细信息
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Slow synaptic inhibition mediated by metabotropic glutamate receptor activation of GIRK channels
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JOURNAL OF NEUROPHYSIOLOGY 2000年 第5期84卷 2284-2290页
作者: Dutar, P Petrozzino, JJ Vu, HM Schmidt, MF Perkel, DJ Univ Penn Dept Neurosci Philadelphia PA 19104 USA
Glutamate is the predominant excitatory neurotransmitter in the vertebrate CNS. Ionotropic glutamate receptors mediate fast excitatory actions whereas metabotropic glutamate receptors (mGluRs) mediate a variety of slo... 详细信息
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G protein-mediated FMRFamidergic modulation of calcium influx in dissociated heart muscle cells from squid, Loligo forbesii
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JOURNAL OF PHYSIOLOGY-LONDON 2000年 第2期525卷 471-482页
作者: Chrachri, A Ödblom, M Williamson, R Marine Biol Assoc United Kingdom Lab Plymouth PL1 2PB Devon England Univ Plymouth Dept Biol Plymouth PL4 8AA Devon England
1. The actions of the neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) on the L-type (I-Ca,I-L) and T-type (I-Ca,I-T) calcium currents were investigated in muscle cells dissociated from the heart of squid, Loligo forbseii... 详细信息
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Heterotrimeric G-proteins of a filamentous fungus regulate cell wall composition and susceptibility to a plant PR-5 protein
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PLANT JOURNAL 2000年 第1期22卷 61-69页
作者: Coca, MA Damsz, B Yun, DJ Hasegawa, PM Bressan, RA Narasimhan, ML Purdue Univ Ctr Plant Environm Stress Physiol W Lafayette IN 47907 USA
Membrane permeabilizing plant defensive proteins first encounter the fungal cell wall that can harbor specific components that facilitate or prevent access to the plasma membrane. However, signal transduction pathways... 详细信息
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Modulation of pacemaker activity by salmon gonadotropin-releasing hormone (sGnRH) in terminal nerve (TN)-GnRH neurons
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JOURNAL OF NEUROPHYSIOLOGY 2000年 第5期83卷 3196-3200页
作者: Abe, H Oka, Y Univ Tokyo Grad Sch Sci Misaki Marine Biol Stn Kanagawa 2380225 Japan
The terminal nerve (TN)-gonadotropin-releasing hormone (GnRH) neurons project widely in the brain instead of the pituitary and show endogenous pacemaker activity that is dependent on the physiological conditions of th... 详细信息
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The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins
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JOURNAL OF BIOLOGICAL CHEMISTRY 2000年 第33期275卷 25299-25307页
作者: Zhang, BL Zhang, YQ Wang, ZX Zheng, Y Univ Tennessee Dept Biochem Memphis TN 38163 USA Acad Sinica Inst Biophys Beijing 100101 Peoples R China
The biological activities of Rho family GTPases are controlled by their guanine nucleotide binding states in cells. Here we have investigated the role of Mg2+ cofactor in the guanine nucleotide binding and hydrolysis ... 详细信息
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Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex
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JOURNAL OF PHYSIOLOGY-LONDON 2000年 第3期528卷 489-496页
作者: Zilberter, Y Karolinska Inst Dept Neurosci Div Neuroanat & Brain Dev S-17177 Stockholm Sweden
1. Dual whole-cell recordings were made in layer 2/3 of the rat neocortex in synaptically connected pyramidal cells and fast-spiking non-accommodating (FSN) interneurons. In 75% of cell pairs (n = 80), the cells forme... 详细信息
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