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光果甘草提取物、甘草酸、18α-和18β- 甘草次酸对鼠伤寒沙门氏菌突变的抑制作用

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现代药物与临床 1995年第1期10卷 37页

作者： Zani-F 高连用

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MUTAGENIC ACTIVITY OF SELENIUM-COMPOUNDS

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MUTATION RESEARCH 1979年第2期66卷 175-179页

作者： NODA, M TAKANO, T SAKURAI, H KEIO UNIV SCH MED DEPT PREVENT MED & PUBL HLTH TOKYO 160 JAPAN

The mutagenicities of selenate .**GRAPHIC**. and selenite .**GRAPHIC**. were determined by 2 bacterial assay systems: Kada''s [Bacillus subtilis] rec-assay and Ames''s Salmonella test. In both assays, the compounds were weak mutagents. In the Salmonella test, selenate (0.05 revertants/nmole) and selenite (0.2 revertants/nmole) gave rise to base-pair substitution. [Human applicability is discussed.].

关键词：枯草芽孢杆菌/药物作用药物评价临床前诱变剂突变鼠伤寒沙门菌/药物作用硒/药理学

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MICROSOME-MEDIATED MUTAGENICITIES OF DIHYDRODIOLS OF 7,12-DIMETHYLBENZ[A]ANTHRACENE - HIGH MUTAGENIC ACTIVITY OF 3,4-DIHYDRODIOL

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1978年第4期83卷 1468-1473页

作者： MALAVEILLE, C BARTSCH, H TIERNEY, B GROVER, PL SIMS, P INT AGCY RES CANC CHEM CARCINOGENES UNIT 150 COURS ALBERT THOMAS F-69372 LYONS FRANCE ROYAL CANC HOSP CHESTER BEATTY RES INST INST CANC RES LONDON SW3 6JB ENGLAND

7,12-Dimethylbenz[a]anthracene and its 3,4- 5,6- 8,9- and 10,11-dihydrodiols were tested for mutagenicity toward Salmonella typhimurium TA100 in the presence of rat liver postmitochondrial supernatants from Aroclor-treated rats. At nontoxic concentrations, the non-K-region 3,4-dihydrodiol was 6-fold more active than the parent hydrocarbon. At these concentrations, the 8,9-dihydrodiol showed some mutagenic activity, but the 5,6- and 10,11-dihydrodiols were inactive.

关键词： 9 10-二甲基-1 2-苯并蒽/类似物和衍生物 9 10-二甲基-1 2-苯并蒽/代谢苯并(a)蒽类/类似物和衍生物生物转化二醇类/代谢微粒体肝/代谢诱变剂鼠伤寒沙门菌/药物作用鼠伤寒沙门菌/遗传学构效关系动物女(雌)性大鼠

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INTERACTIVE MUTAGENICITY OF SODIUM NITRITE, DIMETHYLAMINE, METHYLUREA AND ETHYLUREA

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MUTATION RESEARCH 1975年第2期31卷 109-114页

作者： COUCH, DB FRIEDMAN, MA VIRGINIA COMM UNIV MED COLLHLTH SCI DIVDEPT PHARMACOLRICHMONDVA 23298

Groups of mice were treated per os with sodium nitrite either alone or in combination with nitrosatable amino compounds and tested in the host mediated assay. When mice were treated with sodium nitrite in combination with dimethylamine a small(4-fold) but significant increase in mutant frequency (MF) was observed. Ethylurea or methylurea in combination with sodium nitrite induced 10- or 850-fold increases in MF, respectively. The response to methylurea was dose-dependent with a 6- and 30-fold increase in MF at 5.4 and 11.5 mg/kg NaNO2 and a 6-fold increase at 108 mg/kg methylurea. That this response reflected gastric nitrosation was shown by the disappearance of the response if NaNO2 administration preceded methylurea treatment by 10 min. High MF's were observed if NaNO2 was administered 10 or 20 min after methylurea.

关键词：二甲胺类/投药和剂量二甲胺类/药理学剂量效应关系药物药物相互作用甲脲化合物/投药和剂量甲脲化合物/药理学诱变剂/药理学突变亚硝酸盐类/投药和剂量亚硝酸盐类/药理学亚硝胺类/药理学鼠伤寒沙门菌/药物作用钠/投药和剂量钠/药理学时间因素尿素/投药和剂量尿素/类似物和衍生物尿素/药理学动物男(雄)性小鼠

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RELATIONSHIPS OF ANTIBIOTICS IN ANIMAL FEEDS AND SALMONELLOSIS IN ANIMALS AND MAN

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JOURNAL OF ANIMAL SCIENCE 1975年第6期40卷 1222-1236页

作者： FINLAND, M BOSTON CITY HOSP CHANNING LABBOSTONMA 02118

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MUTAGENICITY OF METRONIDAZOLE - ACTIVATION BY MAMMALIAN LIVER-MICROSOMES

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1975年第2期66卷 520-525页

作者： ROSENKRANZ, HS SPECK, WT COLUMBIA UNIV COLL PHYS & SURGDEPT MICROBIOLNEW YORKNY 10032 COLUMBIA UNIV COLL PHYS & SURGDEPT PEDIATNEW YORKNY

The mutagenicity of metronidazole, a widely used chemotherapeutic agent, for Salmonella typhimurium was confirmed. Moreover using a mutant of of S. typhimurium unable to activate metronidazole to a genetically active metabolite, it is shown that this activation can be carried out by a microsomal preparation devived from rat liver. Heretofore it had been postulated that this metabolic event was catalyzed solely by enzymes present in protozoa and anaerobic bacteria. The present findings which indicate that mammalian enzymes can activate metronidazole to a genetically active intermediate may have a direct relevance to the carcinogenicity of this agent.

关键词：组氨酸/代谢甲硝唑/代谢甲硝唑/药理学微粒体肝/代谢诱变剂/代谢诱变剂/药理学鼠伤寒沙门菌/药物作用鼠伤寒沙门菌/代谢动物大鼠

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MUTAGENESIS BY INSERTION OF A DRUG-RESISTANCE ELEMENT CARRYING AN INVERTED REPETITION

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JOURNAL OF MOLECULAR BIOLOGY 1975年第4期97卷 561-&页

作者： KLECKNER, N CHAN, RK TYE, BK BOTSTEIN, D MIT DEPT BIOLCAMBRIDGEMA 02139

A novel genetic element, which carries genes conferring tetracycline resistance (flanked by a 1400 base-pair inverted repetition), is capable of translocation as a unit from one DNA molecule to another. The tet R element, which is found in nature on a variety of R-factors, was acquired by bacteriophage P22 (producing P22Tc-10 and P22Tc-106) and has now been observed to insert into a large number of different sites on the Salmonella chromosome. Insertion of the tet R element is mutagenic when it occurs within a structural gene, and polar when it occurs within an operon. Insertion of the element is usually precise, occurring without loss of information on the recipient DNA molecule. Excision, on the other hand, is usually not precise, although excisions precise enough to restore a gene function can always be detected at low frequencies. Both insertion and excision processes are independent of the recA function.

关键词：染色体畸变染色体图 DNA 病毒/生物合成抗药性微生物/药物作用基因频率突变核酸构象沙门菌噬菌体/药物作用沙门菌噬菌体/代谢鼠伤寒沙门菌/药物作用鼠伤寒沙门菌/代谢种特异性四环素/药理学转导遗传易位遗传

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MUTAGENICITY STUDIES WITH CAPTAN, CAPTOFOL, FOLPET AND THALIDOMIDE

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FOOD AND COSMETICS TOXICOLOGY 1975年第1期13卷 55-61页

作者： KENNEDY, GL ARNOLD, DW KEPLINGER, ML IND BIO TEST LABS INC NORTHBROOK IL 60062 USA

The three fungicides, captan, captofol and folpet and a structurally related compound, thalidomide, were investigated for possible mutagenic activity by the dominant lethal mutagenicity study in mice and by the host-mediated assay in rats using a histidine auxotroph of Salmonella typhimurium . Male mice were treated with a single ip injection of captan (3 or 6 mg/kg), captofol (1·5 or 3·0 mg/kg), folpet (5 or 10 mg/kg) or thalidomide (50 or 1000 mg/kg). The results of weekly matings with untreated virgin females disclosed no increase in early embryonic death among conceptuses obtained from females mated with the treated males. Groups of male rats were treated by oral intubation for 14 days with one of the three fungicides at levels of 125 or 250 mg/kg/day or with thalidomide at 500 or 1000 mg/kg/day. Indicator micro-organisms recovered from the peritoneal cavity of the treated male rats after a 3-hy residence showed no increase in numbers of revertants. Thus captan, captofol, folpet and thalidomide were not mutagenic in either of these test systems.

关键词：克菌丹/毒性氯/毒性氯仿/分析胚胎植入/药物作用死胎/化学诱导杀真菌剂工业/毒性突变/药物作用苯邻二甲酰亚胺类/毒性生殖/药物作用鼠伤寒沙门菌/药物作用硫化物/毒性沙立度胺/毒性动物女(雌)性男(雄)性小鼠妊娠

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QUANTITATIVE RELATIONSHIP BETWEEN CARCINOGENICITY AND MUTAGENICITY OF POLYAROMATIC HYDROCARBONS IN SALMONELLA-TYPHIMURIUM MUTANTS

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MUTATION RESEARCH 1975年第2期31卷 97-102页

作者： TERANISHI, K HAMADA, K WATANABE, H PUBL HLTH INST HYOGO PREFECTURE 2-1 ARATACHOKOBEHYOGOJAPAN

Mutagenic activities of various polyaromatic hydrocarbons (PAHs) in air pollutants, which are different in carcinogenic activities from each other, were examined with a set of four strains of Salmonella typhimurium (TAI535 series; deep rough strains without excision repair). All the compounds tested were converted to frameshift mutagens when they were metabolized by rat liver homogenate. There was a clear quantitative correlation between carcinogenicity and mutagenicity of PAHs tested in strain TAI538 using the rat liver enzyme induced with both dibenz(a,h)-anthracene and phenobarbital. On the other hand, such a correlation was not obvious in strain TAI537.

关键词：空气污染物苯并(a)蒽类/药理学苯并芘类/药理学致癌物/药理学细胞存活二甲亚砜/药理学剂量效应关系药物酶诱导遗传密码烃类/药理学肝/酶学肝提取物甲基胆蒽/药理学诱变剂/药理学突变苯巴比妥/药理学鼠伤寒沙门菌/药物作用转录遗传动物男(雄)性大鼠

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GENETIC EFFECTS OF POVIDONE-IODINE

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JOURNAL OF PHARMACEUTICAL SCIENCES 1975年第7期64卷 1235-1236页

作者： WLODKOWSKI, TJ SPECK, WT ROSENKRANZ, HS COLUMBIA UNIV COLL PHYS & SURGDEPT PEDIATNEW YORKNY 10032 COLUMBIA UNIV COLL PHYS & SURGDEPT MICROBIOLNEW YORKNY 10032

Povidone-iodine is capable of specifically altering the DNA of living cells. This alteration may result in the induction of mutations of the base-substitution type. Because of the known relationship between mutagenic potential and the ability to induce cancer in animals, the present findings raise serious questions concerning the safety of this topical disinfectant.

关键词： DNA核苷酸转移酶类/拮抗剂和抑制剂 DNA修复/药物作用 DNA 细菌/代谢大肠杆菌/酶学诱变剂/药理学聚维酮/类似物和衍生物聚维酮碘/药理学鼠伤寒沙门菌/药物作用鼠伤寒沙门菌/代谢时间因素

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