At present, pathogenesis and mechanism of Parkinson disease (PD) are still *** models of PD are essential tools in studies on etiology and therapy and should mimic the chronic pathological process, histological charac...
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At present, pathogenesis and mechanism of Parkinson disease (PD) are still *** models of PD are essential tools in studies on etiology and therapy and should mimic the chronic pathological process, histological characteristics and motor behavior *** recent years, transgenic mice have been widely utilized to study the mechanism of PD, and it has become imperative that a PD mouse model of motor behavioral dysfunction be ***: To compare the behavioral and histochemical characters of two neurotoxic mice model induced with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1, 2, 3, 6 -tetrahydropyridine (MPTP), and a better method to mimic Parkinson disease will be found ***: Parallel ***: Laboratory of Molecular Genetics, Department of Medical Genetics, Shanghai Jiao Tohg ***: Sixty 129Sv/C57BL6J male wild mice, SPF grade, 8 - 12 weeks old, weighing 20 - 25 g, were provided by Experimental Animal Center, Shanghai Jiao Tong *** the surgery operation was performed according to the rules of Shanghai Jiaotong University Animal ***: The experiment was carried out in the Laboratory of Molecular Genetics (National Key Laboratory), Department of Medical Genetics, Shanghai Jiao Ttong University from March to August 2006.①Thirty-two male mice were randomly divided into control group and drug treatment group with 16 mice in each *** was carried out and 6-OHDA was administrated to substantia nigra pars compacta (SNpc) and nigra-striatum pathway according to the different parameters with intoxication *** was injected to the other 16 mice according to the same paradigm.1 mg/kg apomorphine was injected intraperitoneally 2 weeks later after surgery to induce the imbalanced rotation behavior for 40 minutes.②Twenty-eight mice were randomly divided into 4 groups with 7 in each group, including low-dose, moderate-dose, high-dose groups and negative control ***,
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