Reports on cell-mediated immune responses and loss of hepatitis B e-Antigen (HBeAG) during successful lamivudine and famciclovir combination therapy for chronic replicating hepatitis B virus infection. Improvement of ...
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Reports on cell-mediated immune responses and loss of hepatitis B e-Antigen (HBeAG) during successful lamivudine and famciclovir combination therapy for chronic replicating hepatitis B virus infection. Improvement of the necroinflammatory and fibrotic changes in the liver; Correspondence between peripheral blood mononuclear cells and biochemical and serological events.
Noncontiguous multidermatomal herpes tester is very rare in both immunocompetent and immunocompromised persons. Most of the reported cases have been limited to 2 noncontiguous dermatomes. This unique presentation has ...
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Noncontiguous multidermatomal herpes tester is very rare in both immunocompetent and immunocompromised persons. Most of the reported cases have been limited to 2 noncontiguous dermatomes. This unique presentation has been referred to as tester duplex uni lateralis or bilateralis, depending on whether one or both halves of the body are involved. Granulomatous dermatitis at sites of herpes tester scars, a rare isotopic response, has only been reported in persons with contiguous dermatomes of tester. We describe an immunocompromised patient who developed herpes tester in 7 disparate dermatomes. Three months after resolution of the tester, the patient developed a granulomatous dermatitis in a zosteriform distribution at the sites of previous infection.
Mice were infected with herpes simplex virus type 1 (HSV-1) via the ear pinna. Famciclovir therapy was commenced on days 2-7 post infection (p.i.). The ipsilateral and contralateral trigeminal (TG) and third cervical ...
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Mice were infected with herpes simplex virus type 1 (HSV-1) via the ear pinna. Famciclovir therapy was commenced on days 2-7 post infection (p.i.). The ipsilateral and contralateral trigeminal (TG) and third cervical ganglia (CIII) from individual mice were tested for latency 1 and 6 months after infection by explant culture or in situ hybridization for latency-associated transcripts (LAT). There were significantly fewer LAT-positive neurons in ipsilateral and contralateral TG (but not CIII) when therapy was delayed by up to 6 days. There was a low correlation between the number of LAT-positive neurons and reactivation by explant culture. Latency data for individual ganglia, compared with those from previous studies, allow us to rationalize differences between the effects of nucleosides on the establishment of latency in different anatomical sites and when tissues are evaluated using different techniques. The implications of the findings for the use of famciclovir to counter HSV latency in humans are addressed.
Editorial. Comments on the effectivity of nucleoside analogue therapy in the treatment of chronic hepatitis B virus infection. Observation of reinfection in patients with high levels of circulating virus; Association ...
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Editorial. Comments on the effectivity of nucleoside analogue therapy in the treatment of chronic hepatitis B virus infection. Observation of reinfection in patients with high levels of circulating virus; Association of hepatitis B immunoglobulin with mercury toxicity; Use of lamivudine therapy for post liver transplant patients.
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