In this investigation a new classification technique based on artificial neural network (ANN) and exponent evaluation method (EEM) has been developed to classify the danger classes of coal and gas outburst in deep min...
详细信息
In this investigation a new classification technique based on artificial neural network (ANN) and exponent evaluation method (EEM) has been developed to classify the danger classes of coal and gas outburst in deep mines. A weight computing model of mutual affecting factors is derived from backward algorithm of ANN (BA-ANN), which diminishes the influence of factitious factor, the environment factor and the time factor to the weight. The BA-ANN model is used for modeling the correlation between danger class and 12 affecting factors of coal and gas outburst and calculating weights of interconnection factors, which performs very well. In order to classify danger classes in a daily routine, the EEM with the well trained weights which are from BA-ANN, is performed in a deep mine. The case study shows that this new technique is useful to classify danger classes with quick and accurate computation. Moreover, the weight computing model of BA-ANN can be extended to other safety issue in different fields as well. (C) 2009 Elsevier Ltd. All rights reserved.
We propose a new method for haplotyping, genotype calling, and association testing based on a dictionary model for haplotypes. In this framework, a haplotype arises as a concatenation of conserved haplotype segments, ...
详细信息
We propose a new method for haplotyping, genotype calling, and association testing based on a dictionary model for haplotypes. In this framework, a haplotype arises as a concatenation of conserved haplotype segments, drawn from a predefined dictionary according to segment specific probabilities. The observed data consist of unphased multimarker genotypes gathered on a random sample of unrelated individuals. These genotypes are subject to mutation, genotyping errors, and missing data. The true pair of haplotypes corresponding to a person's multimarker genotype is reconstructed using a Markov chain that visits haplotype pairs according to their posterior probabilities. Our implementation of the chain alternates Gibbs steps, which rearrange the phase of a single marker, and Metropolis steps, which swap maternal and paternal haplotypes from a given maker onward. Output of the chain include the most likely haplotype pairs, the most likely genotypes at each marker, and the expected number of occurrences of each haplotype segment. Reconstruction accuracy is comparable to that achieved by the best existing algorithms. More importantly, the dictionary model yields expected counts of conserved haplotype segments. These imputed counts can serve as genetic predictors in association studies, as we illustrate by examples on cystic fibrosis, Friedreich's ataxia, and angiotensin-I converting enzyme levels.
暂无评论