In this paper, we study the problem of D-optimal experimental design under two linear constraints, which can be interpreted as simultaneous restrictions on the size and on the cost of the experiment. For computing a s...
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In this paper, we study the problem of D-optimal experimental design under two linear constraints, which can be interpreted as simultaneous restrictions on the size and on the cost of the experiment. For computing a size- and cost-constrained approximate D-optimal design, we propose a specification of the "barycentric" multiplicative algorithm with sequential removal of redundant design points. We analytically prove convergence results for the proposed algorithm and numerically demonstrate its favorable properties compared to competing methods.
Consider a linear regression experiment with uncorrelated real-valued observations and a finite design space. An approximate experimental design is stratified if it allocates given proportions of trials to selected no...
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Consider a linear regression experiment with uncorrelated real-valued observations and a finite design space. An approximate experimental design is stratified if it allocates given proportions of trials to selected non-overlapping partitions of the design space. To calculate an approximate D-optimal stratified design, we propose two multiplicative methods: a re-normalisation heuristic and a barycentric algorithm, both of which are very simple to implement. The re-normalisation heuristic is generally more rapid, but for the barycentric algorithm, we can prove monotonic convergence to the optimum. We also develop rules for the removal of design points that cannot support any D-optimal stratified design, which significantly improves the speed of both proposed multiplicative methods. (C) 2013 Elsevier B.V. All rights reserved.
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