检索结果-内蒙古大学图书馆

62nd IEEE International Solid-State Circuits Conference (ISSCC)

作者： Ahn, Jinhong Hong, Sang Hoon Park, Youngjune Seoul Natl Univ Seoul 151742 South Korea Kyung Hee Univ Dept Elect & Radio Engn Yongin 130701 South Korea Seoul Natl Univ Dept Elect Engn Seoul 151742 South Korea

ISBN: (纸本)9781479962242

This paper presents a double-side CMOS-carbon nanotube (CNT) sensor array for simple bare-die measurements in a medical environment based on a 0.35 mu m standard CMOS process. This scheme allows robust measurements due to its inherent back-side rectifying diodes with a high latch-up resistance. In particular, instead of using pads, only two contact metal structures: a wide ring structure around the sensor area on the front side and a plate structure at the backside are used for both power and single I/O line. The back-side rectification is made possible by creating VDD and VSS through the back-side and front-side, respectively. The single I/O line is conditioned such that it doubles as either the power source or the ground, depending on whether the chip is face down or face up. A modified universal asynchronous receiver/transmitter (UART) serial communication scheme with pulse based I/O signal transmission is developed to reduce the power degradation during the signaling intervals. In addition, communication errors and I/O power dissipation for the receiver path are minimized by using level sensitive switch control and double sampling difference amplifier. In order to implement these special functions, a controller chip with a special I/O protocol is designed. Using this controller chip, issuing commands and receiving data can both be performed on a single line and the results are flexibly measured through either the backside or the front side of the chip contacts. As a result, a stable operation of under 150 mW maximum power at 2 MHz data rate can be achieved. The double-side chips with 32 x 32 and 64 x 64 sensor arrays occupy areas of 1.9 x 2.3 mm(2) and 3.7 x 3.9 mm(2), respectively.

关键词： Backside rectification bare-die measurement biosensor array CMOS carbon nanotube (CNT) controller double-side flippable chip position level sensitive switch control medical pulse communication universal asynchronous receiver/transmitter (UART)

来源：评论

学校读者我要写书评

暂无评论

High-throughput impedance spectroscopy biosensor array chip

引用

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 2014年第2012期372卷 5-5页

作者： Liu, Xiaowen Li, Lin Mason, Andrew J. Michigan State Univ Dept Elect & Comp Engn E Lansing MI 48824 USA

Impedance spectroscopy is a powerful tool for characterizing materials that exhibit a frequency dependent behaviour to an applied electric field. This paper introduces a fully integrated multi-channel impedance extraction circuit that can both generate AC stimulus signals over a broad frequency range and also measure and digitize the real and imaginary components of the impedance response. The circuit was fabricated in a 0.5 mu m complementary metal-oxide semiconductor. Tailored for cellular membrane interface characterization, the signal generator produces sinusoidal waves from 10 mHz to 10 kHz. To suit a variety of applications, the impedance extraction circuit provides a programmable current measurement range from 100 pA to 100 nA with a measured resolution of approximately 100 fA. Occupying only 0.045 mm(2) per measurement channel, the circuit is compact enough to include nearly 200 channels in a 3 x 3 mm(2) die area.

关键词： complementary metal-oxide semiconductor impedance spectroscopy biosensor array frequency synthesizer

来源：评论

学校读者我要写书评

暂无评论

Disposable micro-fluidic biosensor array for online parallelized cell adhesion kinetics analysis on quartz crystal resonators

引用

MEASUREMENT SCIENCE AND TECHNOLOGY 2010年第8期21卷 085801-085801页

作者： Cama, G. Jacobs, T. Dimaki, M. I. Svendsen, W. E. Hauptmann, P. Naumann, M. Otto VonGuericke Univ Magdegurg Inst Micro & Sensor Syst D-39106 Magdeburg Germany Otto VonGuericke Univ Magdegurg Inst Expt Internal Med D-39120 Magdeburg Germany Tech Univ Denmark Dept Micro & Nanotechnol DK-2800 Lyngby Denmark

In this contribution we present a new disposable micro-fluidic biosensor array for the online analysis of adherent Madin Darby canine kidney (MDCK-II) cells on quartz crystal resonators (QCRs). The device was conceived for the parallel cultivation of cells providing the same experimental conditions among all the sensors of the array. As well, dedicated sensor interface electronics were developed and optimized for fast spectra acquisition of all 16 QCRs with a miniaturized impedance analyzer. This allowed performing cell cultivation experiments for the observation of fast cellular reaction kinetics with focus on the comparison of the resulting sensor signals influenced by different cell distributions on the sensor surface. To prove the assumption of equal flow circulation within the symmetric micro-channel network and support the hypothesis of identical cultivation conditions for the cells living above the sensors, the influence of fabrication tolerances on the flow regime has been simulated. As well, the shear stress on the adherent cell layer due to the flowing media was characterized. Injection molding technology was chosen for the cheap mass production of disposable devices. Furthermore, the injection molding process was simulated in order to optimize the mold geometry and minimize the shrinkage and the warpage of the parts. MDCK-II cells were cultivated in the biosensor array. Parallel cultivation of cells on the gold surface of the QCRs led to first observations of the impact of the cell distribution on the sensor signals during cell cultivation. Indeed, the initial cell distribution revealed a significant influence on the changes in the measured acoustic load on the QCRs suggesting dissimilar cell migrations as well as proliferation kinetics of a non-confluent MDCK-II cell layer.

关键词： acoustic biosensors microfluidics injection molding cell adhesion biosensor array impedance spectroscopy

来源：评论

学校读者我要写书评

暂无评论

Fading of nanocurcumin-based configured biosensor array for differentiation of carrier proteins in biological fluids

引用

MICROCHEMICAL JOURNAL 2022年 175卷 107169-107169页

作者： Rasouli, Zolaikha Ghavami, Raouf Univ Kurdistan Fac Sci Chem Dept Chemometr Lab POB 416 Sanandaj *** Iran

Herein, a simple, novel, and cost-effective biosensor array is developed for the differentiation of carrier proteins (i.e. human serum albumin (HSA), bovine serum albumin (BSA), transferrin (TRF), immunoglobulin G (IgG), fibrinogen (Fb) and casein (Cas) based on fading nanocurcumin in alkaline solutions. We found that the carrier proteins show different inhibitory effects with diverse extents on the alkaline decomposition of nanocurcumin. In the other words, in the presence of carrier proteins, the biosensor array produces fingerprint-like absorbance patterns to identify each carrier protein. The absorbance patterns of this biosensor array can be analyzed by linear discrimination analysis (LDA) and hierarchical cluster analysis (HCA). The six carrier proteins have been well discriminated in different concentrations levels. Furthermore, complex mixtures of HSA and TRF with a total concentration of 25 mu M and different mole ratios are also discriminated without errors. Also, the HSA as an example of carrier proteins has been well determined in the range of 5-75 mu M. The results revealed that the biosensor array shows high selectivity to the carrier proteins in the presence of other interfering substances. The analytical performance of the biosensor array is examined by the differentiation of carrier proteins in human urine and serum biofluids. It should be noted that the biosensor array is very simple, label-free, and selective, and only restricted sensor elements are required for attaining a high differentiation capability of carrier proteins.

关键词： biosensor array Nanocurcumin Carrier protein Differentiation Linear discrimination analysis Hierarchical clustering analysis

来源：评论

学校读者我要写书评

暂无评论

CMOS Amperometric Instrumentation and Packaging for biosensor array Applications

引用

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 2011年第5期5卷 439-448页

作者： Li, Lin Liu, Xiaowen Qureshi, Waqar A. Mason, Andrew J. Michigan State Univ Dept Elect & Comp Engn E Lansing MI 48824 USA

An integrated CMOS amperometric instrument with on-chip electrodes and packaging for biosensor arrays is presented. The mixed-signal integrated circuit supports a variety of electrochemical measurement techniques including linear sweep, constant potential, cyclic and pulse voltammetry. Implemented in 0.5 mu m CMOS, the 3 x 3 mm(2) chip dissipates 22.5 mW for a 200 kHz clock. The highly programmable chip provides a wide range of user-controlled stimulus rate and amplitude settings with a maximum scan range of 2 V and scan rates between 1 mV/sec and 400 V/sec. The amperometric readout circuit provides +/- 500 fA linear resolution and supports inputs up to +/- 47 mu A. A 2 x 2 gold electrode array was fabricated on the surface of the CMOS instrumentation chip. An all-parylene packaging scheme was developed for compatibility with liquid test environments as well as a harsh piranha electrode cleaning process. The chip was tested using cyclic voltammetry of different concentrations of potassium ferricyanide at 100 mV/s and 200 mV/s, and results were identical to measurements using commercial instruments.

关键词： biosensor array biosensor packaging CMOS amperometry CMOS potentiostat

来源：评论

学校读者我要写书评

暂无评论

A Double-Side CMOS-CNT biosensor array With Padless Structure for Simple Bare-Die Measurements in a Medical Environment

引用

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 2015年第6期9卷 815-824页

来源：评论

学校读者我要写书评

暂无评论

High-Sensitivity InGaZnO FET Sensor array With Offset Self-Calibration for Multibiomarker Sensing

引用

IEEE TRANSACTIONS ON ELECTRON DEVICES 2025年第5期72卷 2740-2746页

作者： Li, Yao Zhou, Yuying Chen, Bing Zhang, Shuaidi Hu, Ke Li, Peiyun Lu, Congyan Wang, Jiawei Yang, Xiaonan Zhang, Feng Zhang, Wenchang Li, Ling Chinese Acad Sci Inst Microelect State Key Lab Fabricat Technol Integrated Circuits Beijing 100029 Peoples R China Univ Chinese Acad Sci Sch Integrated Circuits Beijing 100049 Peoples R China Zhengzhou Univ Affiliated Hosp 1 Dept Gastroenterol Zhengzhou 450052 Peoples R China Zhengzhou Univ Sch Informat Engn Zhengzhou 450001 Peoples R China

This work proposes a dual-gate InGaZnO thin-film transistor sensor array for label-free and cross-scale multiple biomarkers detection, including single-stranded deoxyribonucleic acid (ssDNA) and protein CA125. We exploit dual gate modulation for threshold voltage and CMOS-based SAR-assisted digital-to-analog converter (DAC) V-BG calibration circuit to eliminate initial V-TH offset variation caused by different functionalizations, which improve the reliability of the multibiomarker sensor array. At the same time, receptor enhancement on the indium gallium zinc oxide (IGZO) sensing membrane was detected by fluorescence assay, realizing higher sensitivity for biosensor. We demonstrate the sensor array response for pH in static and real-time mode, realizing near-Nernst limit sensitivity (55.02 mV/pH). Furthermore, at the top-gate configuration, with low operation voltage (0.1 V) and low offset variation (about 2 nA), the IGZO sensor array exhibits great performance for biomarker sensing which achieves sensitivity up to 4.426%/decade for ssDNA and 1102 nA/decade for CA125, with the limit of detection (LoD) of 1.67 aM for ssDNA and 0.1 fg/mL for CA125. This biosensor array provides a potential approach to realize miniaturization and high-density integration of multidimensional-biomarker detection.

关键词： Sensors Biomarkers Threshold voltage Sensor arrays Logic gates Proteins Electrodes DNA biosensors Sensitivity biosensor array indium gallium zinc oxide (IGZO) multiple-biomarker sensing offset calibration pH sensor thin-film transistors

来源：评论

学校读者我要写书评

暂无评论

A spectral imaging array biosensor and its application in detection of leukemia cell

引用

SENSORS AND ACTUATORS B-CHEMICAL 2011年第2期156卷 760-764页

作者： Fang, Xiangyi Liu, Chunlong Cheng, Xiaoli Wang, Yaoling Yang, Yucong Xi An Jiao Tong Univ MOE Key Lab Nonequilibrium Synth & Modulat Conden Sch Sci Xian 710049 Peoples R China Xi An Jiao Tong Univ Coll Med Affiliated Hosp 1 Haematol Lab Xian 710049 Peoples R China Second Hosp Xian City Xian Peoples R China

A new type of array immunosensor was developed by combining surface plasmon resonance (SPR) and spectral imaging techniques. The system consisted of a monochromator as the wavelength scanning light source, a polarizer, Kretschmann-Raaether attenuated total reflection (ATR) configuration including array sensor chip, and a CCD camera. The images of transmitting light from ATR were recorded versus the wavelength. By averaging gray scales of the pixels in the area of every gold spot from the image series, the complete spectral resonance curve of all sensing spots on the array can be extracted in parallel. The performance of the developed system was evaluated by analyzing interactions of the anti-CD33 monoclonal antibody to its target leukemic cells using 11 cases of human bone marrow specimens. The specimens were also analyzed with flow cytometry method (FCM) for comparison. The initial results measured by the immunosensor array were corresponded with that of FCM, indicating that the developed parallel method might be clinically suitable for immunophenotyping of acute leukemias. The new sensor array system showed the merits of high-throughput, high sensitivity, high specificity, label free and operation convenient. Spots numbers of the array could be increased if suitable technology were adopted for manipulating the micro bio-liquids on the sensor array chip. (C) 2011 Elsevier B.V. All rights reserved.

关键词： Surface plasmon resonance SPR imaging biosensor array High-throughput analysis

来源：评论

学校读者我要写书评

暂无评论

Application of peptide nucleic acid towards development of nanobiosensor arrays

引用

BIOELECTROCHEMISTRY 2010年第2期79卷 153-161页

作者： Singh, Ravindra P. Oh, Byung-Keun Choi, Jeong-Woo Sogang Univ Interdisciplinary Program Integrated Biotechnol Seoul 121742 South Korea Sogang Univ Dept Chem & Biomol Engn Seoul 121742 South Korea

Peptide nucleic acid (PNA) is the modified DNA or DNA analogue with a neutral peptide backbone instead of a negatively charged sugar phosphate. PNA exhibits chemical stability, resistant to enzymatic degradation inside living cell, recognizing specific sequences of nucleic acid, formation of stable hybrid complexes like PNA/DNA/PNA triplex, strand invasion, extraordinary thermal stability and ionic strength, and unique hybridization relative to nucleic acids. These unique physicobiochemical properties of PNA enable a new mode of detection, which is a faster and more reliable analytical process and finds applications in the molecular diagnostics and pharmaceutical fields. Besides, a variety of unique characteristic features, PNAs replace DNA as a probe for biomolecular tool in the molecular genetic diagnostics, cytogenetics, and various pharmaceutical potentials as well as for the development of sensors/arrays/chips and many more investigation purposes. This review paper discusses the various current aspects related with PNAs, making a new hot device in the commercial applications like nanobiosensor arrays. (C) 2010 Elsevier B.V. All rights reserved.

关键词： PNA DNA biosensor array Microarrays Biochips

来源：评论

学校读者我要写书评

暂无评论

Design requirements for integrated biosensor arrays

Design requirements for integrated biosensor arrays

引用

Conference on Imaging, Manipulation, and Analysis of Biomolecules and Cells - Fundamentals and Applications III

作者： Agah, A Hassibi, A Plummer, JD Griffin, PB Stanford Univ Ctr Integrated Syst Stanford CA 94305 USA

ISBN: (纸本)081945673X

Miniaturization and integration of biosensor platforms is appealing due to smaller reaction volumes, larger numbers of detection sites and integration of various functionalities. Proper design of integrated biosensors is crucial in such systems due to limitation in resources such as power, chip area and cost. The optimal design involves determining the required sensor metrics and achieving these rnetrics with minimum use of the available resources. The system-level requirements of various biosensor arrays are discussed in this paper. We will show here, that while in certain applications, the best sensor performance in terms of signal-to-noise ratio (SNR) or dynamic range (DR) is desirable, in others, these metrics can be traded off with power, area and ease of design and implementation. As a practical example, the design of a high DR sensor array for bioluminescence detection is considered. Various high DR schemes are qualitatively compared in order to determine the advantages and disadvantages of each scheme in terms of SNR and power consumption. Two schemes are shown to be most suitable for such applications: synchronous self-reset with residue readout and read-self reset. The SNR and suitable applications of these techniques are compared in greater detail through behavioral simulations.

关键词： bioluminescence biosensor array dynamic range minimum detectable level signal-to-noise ratio

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：