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Automated SIA e-tongue employing a voltammetric biosensor array for the simultaneous determination of glucose and ascorbic acid

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ELECTROANALYSIS 2006年第1期18卷 82-88页

作者： Gutés, A Ibáñez, AB del Valle, M Céspedes, F Autonomous Univ Barcelona Dept Chem Sensors & Biosensors Grp Barcelona 08193 Spain

An automated voltammetric electronic tongue has been designed employing a biosensor array formed by three different enzymatic Glucose Oxidase (GOD) electrodes and the Sequential Injection Analysis principle. The system is used for its automated training and operation devised for determining glucose and one of its classical interferents, ascorbic acid. The three enzymatic biosensors contain GOD and different metallic catalysts in order to decrease the working potential and to differentiate the response of primary species and interferents. Linear sweep voltammetry has been the chosen technique for data generation and artificial neural networks have been used as the modeling tool. Different learning algorithms have been tried in order to obtaining the best architecture for the neural network. Glucose has been determined in different fruit juice samples by employing this system, correcting the ascorbic acid contents.

关键词： SIA biosensor array e-tongue glucose ascorbic acid artificial neural networks

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Compact Low-Power Impedance-to-Digital Converter for Sensor array Microsystems

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IEEE JOURNAL OF SOLID-STATE CIRCUITS 2009年第10期44卷 2844-2855页

作者： Yang, Chao Jadhav, Sachin R. Worden, R. Mark Mason, Andrew J. Michigan State Univ E Lansing MI 48824 USA

With the rapid progress in CMOS compatible micro-fabrication of biosensors, there is an emerging need to miniaturize biosensor arrays onto the surface of silicon chips that acquire and process sensor data, permitting improved sensitivity, cost and throughput. In this paper, a low power circuit that extracts and digitizes sensor impedance information is presented. Composed of a novel multiplying integrator and a unique bidirectional counter/shifter, the circuit shares resources for impedance extraction and digitization to maximize hardware efficiency. The extremely compact size of the circuit enables the implementation of sensor array microsystems with simultaneous multi-channel readout. Fabricated in 0.5 mu m CMOS, the circuit consumes 6 mu W at 3 V and occupies only 0.06 mm(2), permitting over 100 readout channels within a 3 x 3 mm die. Circuit performance has been verified with a biosensor for gramicidin ion channel embedded in a tethered bilayer lipid membrane.

关键词： biosensor array electrochemical instrumentation impedance spectroscopy impedance-to-digital converter

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An Integrated ISFET Sensor array

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SENSORS 2009年第11期9卷 8831-8851页

作者： Nakazato, Kazuo Nagoya Univ Grad Sch Engn Dept Elect Engn & Comp Sci Chikusa Ku Aichi 4648603 Japan

A monolithically integrated ISFET sensor array and interface circuit are described. A new high-density, low-power source-drain follower was developed for the sensor array. ISFETs were formed by depositing Au/Ti extended-gate electrodes on standard MOSFETs, then thin silicon nitride layers using catalytic chemical vapor deposition and/or SU-8 protective layers were formed on the extended-gate electrodes. Applications for the array include: (1) pH detection by statistical distribution observing time and space fluctuations;(2) DNA detection using thiol-modified or silane-coupled oligonucleotides;(3) bio-image sensing by converting photons to electrons using Photosystem I of Thermosynechococcus elongatus, and sensing the converted electric charges by ISFETs.

关键词： ISFET biosensor array source-drain follower CMOS biotechnology

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A Micromachined Quartz Resonator array for Biosensing Applications

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JOURNAL OF MICROELECTROMECHANICAL SYSTEMS 2009年第3期18卷 522-530页

作者： Kao, Pine Doerner, Steffen Schneider, Thomas Allara, David Hauptmann, Peter Tadigadapa, Srinivas Penn State Univ Dept Elect Engn University Pk PA 16802 USA Otto VonGuericke Univ Magdegurg TEPROSA D-39016 Magdeburg Germany Otto VonGuericke Univ Magdegurg Dept Elect Engn & Informat Technol D-39016 Magdeburg Germany Otto VonGuericke Univ Magdegurg Inst Micro & Sensor Syst D-39016 Magdeburg Germany Penn State Univ Dept Chem University Pk PA 16802 USA Penn State Univ Mat Res Inst University Pk PA 16802 USA Inst Automat & Commun D-39106 Magdeburg Germany

An 8-pixel micromachined quartz crystal resonator array with a fundamental resonance frequency of 66 MHz has been designed, fabricated, and tested. A compact impedance-spectrum-analyzer electronic interface has been developed and combined with the quartz resonator array to form the biosensing system. The sensor array was calibrated using water-glycerol solutions, and the performance was found to be exactly as expected. Measurement of the crosstalk between the sensor pixels showed an isolation of similar to 30 dB. Selective functionalization of the pixels was achieved through the use of aqueous 3, 3'-Dithiobis (sulfosuccin-imidylpropionate) (DTSSP) molecules. The adsorption of avidin on DTSSP gave a frequency signal of 60 kHz in comparison to unfunctionalized pixels. The specific adsorption of avidin on functionalized pixels was confirmed through fluorescence microscopy. Comparing the performance of the micromachined quartz crystal microbalance (QCM) with a commercial 5-MHz device, we found that the micromachined QCM has a 4.25 times higher signal-to-noise ratio. Based on the measurement of the noise and using three times the frequency noise as the limit for the detection of avidin molecules, we expect to resolve a minimum of similar to 1/960 of a monolayer of avidin corresponding to an aerial mass density resolution of 0.7 ng/cm(2). [2008-0196]

关键词： biosensor array impedance spectrum analyzer quartz crystal microbalance (QCM) quartz micromachining

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Electrochemical biosensor array for liver diagnosis using a silanization technique on nano-porous silicon electrode

Electrochemical biosensor array for liver diagnosis using a ...

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IEEE Nanotechnology Materials and Devices Conference

作者： Song, Min-Jung Yun, Dong-Hwa Min, Nam-Ki Hong, Suk-In Korea Univ Dept Chem & Biol Engn Seoul 136701 South Korea

ISBN: (纸本)9781424405404

Cholesterol, bilirubin and ALT/AST present in the serum are often used as biomarkers for liver diseases. For this study, we describe our biosensor array system consisting of cholesterol, bilirubin and glutamate sensors. We determined that porous silicon (PS) layers formed on each working electrode greatly increased the effective surface area. The electrodes in the sampling wells minimized a cross-interference effect to permit multiple sampling by immobilization of the enzymes using a silanization technique. The device sensitivities observed were 0.2656 mu A/mM for cholesterol, 0.15354 mA/mM for bilirubin, 0.13698 mu A/(U/l) for ALT and 0.45439 mu A/(U/l) for AST.

关键词： cholesterol sensr bilirubin sensor glutamate sensor ALT/AST activities biosensor array porous silicon electrochemical biosensor

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State of the Art in the Field of Electronic and Bioelectronic Tongues - Towards the Analysis of Wines

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ELECTROANALYSIS 2009年第23期21卷 2509-2520页

作者： Zeravik, Jiri Hlavacek, Antonin Lacina, Karel Skladal, Petr Masaryk Univ Fac Sci Dept Biochem CS-61137 Brno Czech Republic

This review compares various types of (bio)electronic tongues. The design and principles of potentiometric and voltammetric electronic tongues are discussed together with applications in food and environmental analysis. Different approaches towards bioelectronic tongue are presented. Several methods for evaluation and interpretation of the measured data are described. Finally, the potential of such devices for analysis of wine is discussed.

关键词： Electronic tongue Bioelectronic tongue Sensor array biosensor array Electrochemical sensor Amperometry Voltammetry Potentiometry biosensors

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Influence of statistical variations in cell distribution on the proliferation kinetics of Madin-Darby canine kidney cells on quartz crystal resonator

Influence of statistical variations in cell distribution on ...

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23rd Eurosensors Conference

作者： Cama, G. Bolaeva, K. Jacobs, T. Hartmann, M. Hirsch, S. Naumann, M. Hauptmann, P. Otto VonGuericke Univ Magdegurg Inst Micro & Sensor Syst D-39106 Magdeburg Germany Otto VonGuericke Univ Magdegurg Inst Expt Internal Med D-39106 Magdeburg Germany

The influence of statistical variations in cell distribution on the proliferation of Madin-Darby canine kidney (MDCK-II) cells was analyzed. MDCK-II cells were cultivated in parallel on 4 quartz crystal resonators in a bioreactor chip. Results of proliferation experiments with different initial grade of confluence were compared. Light microscope pictures of the sensor surface and impedance spectra were continuously acquired. CFD simulation results of the bioreactor chip were employed to verify experimental conditions. Results show that especially at low confluency dissimilar development of non-confluent MDCK-II cell layers and resulting changes in acoustic load depend significantly on initial cell distribution.

关键词： biosensor array Cell adhesion Cell distribution Impedance analysis Quartz Crystal Resonator Acoustic load

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Influence of statistical variations in cell distribution on the proliferation kinetics of Madin-Darby canine kidney cells on quartz crystal resonator

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Procedia Chemistry 2009年第1期1卷 373-376页

作者： G. Cama K. Bolaeva T. Jacobs M. Hartmann S. Hirsch M. Naumann P. Hauptmann Institute of Micro and Sensor Systems Otto von Guericke University Magdeburg Magdeburg 39106 Germany Institute of Experimental Internal Medicine Otto von Guericke University Magdeburg Magdeburg 39120 Germany

关键词： biosensor array Cell adhesion Cell distribution Impedance analysis Quartz Crystal Resonator Acoustic load

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Bioelectronic tongue for the simultaneous determination of urea, creatinine and alkaline ions in clinical samples

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biosensorS & BIOELECTRONICS 2008年第6期23卷 795-802页

作者： Gutierrez, Manuel Alegret, Salvador del Valle, Manel Univ Barcelona Dept Chem Sensors & Biosensors Grp Bellaterra 08193 Spain

Urea and creatinine biosensors based on urease and creatinine deiminase, respectively, covalently immobilized onto ammonium selective electrodes, were included in an array together with sensors sensitive to ammonium, potassium and sodium. Generic sensors to alkaline ions were also included. All the sensors used were of all-solid-state type, employing polymeric membranes and having rather nonspecific response characteristics. A response model based on artificial neural networks was built and tested for the simultaneous determination of urea, creatinine, ammonium, potassium and sodium. The results show that it is possible to obtain a good multivariate calibration model. In this way, the developed bioelectronic tongue was successfully applied to multidetermination of the five species in raw and spiked urine samples. Predicted concentrations showed a good agreement with reference methods of analysis, allowing a simple direct method for determining urea and creatinine in real samples. At the same time, this method permitted to obtain the concentrations of the alkaline interferences (endogenous ammonium, potassium and sodium) without the need of eliminating them. (C) 2007 Elsevier B.V. All rights reserved.

关键词： biosensor array potentiometric electronic tongue urea creatinine artificial neural networks

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Fully integrated impedance spectroscopy systems for biochemical sensor array

Fully integrated impedance spectroscopy systems for biochemi...

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IEEE Biomedical Circuits and Systems Conference

作者： Yang, Chao Rairigh, Daniel Mason, Andrew Michigan State Univ E Lansing MI 48824 USA

ISBN: (纸本)9781424415243

With rapid progress in the miniaturization of biosensors, array microsystems utilizing impedance spectroscopy (IS) are of emerging interest. Focused on the electronics portion of such IS microsystems, this paper analyzes FFT-based and frequency response analyzer (FRA)-based approaches and compares them for hardware efficiency in array applications. For the chosen FRA-based approach, two possible systems are described and their circuit-level realizations are presented, one targeting high accuracy applications and the other prioritizing rapid interrogation.

关键词： impedance spectroscopy biosensor array microsystem analog/mixed signal integrated circuit

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