This paper reports selected results of the MNS-DIAG research project. The project is aimed at facilitating access of research teams coming from academia to fully equipped CMOS/MEMS R&D and manufacturing line and t...
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This paper reports selected results of the MNS-DIAG research project. The project is aimed at facilitating access of research teams coming from academia to fully equipped CMOS/MEMS R&D and manufacturing line and thus allowing for inflow of innovative microdevice concepts and development of demonstrators. To address the important grand societal challenges related to well-being and health in the ageing society, the project has been focused on application of micro- and nano-systems for chemical/bio-medical analysis and diagnostics. Out of five demonstrators elaborated within the MNS-DIAG, three are shortly described here, namely, Lab-on-a-chip for oocytes characterization, Micromechanical biosensors array and Integrated MEMS detector for dynamic humidity measurement in medical applications.
The influence of statistical variations in cell distribution on the proliferation of Madin-Darby canine kidney (MDCK-II) cells was analyzed. MDCK-II cells were cultivated in parallel on 4 quartz crystal resonators in ...
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The influence of statistical variations in cell distribution on the proliferation of Madin-Darby canine kidney (MDCK-II) cells was analyzed. MDCK-II cells were cultivated in parallel on 4 quartz crystal resonators in a bioreactor chip. Results of proliferation experiments with different initial grade of confluence were compared. Light microscope pictures of the sensor surface and impedance spectra were continuously acquired. CFD simulation results of the bioreactor chip were employed to verify experimental conditions. Results show that especially at low confluency dissimilar development of non-confluent MDCK-II cell layers and resulting changes in acoustic load depend significantly on initial cell distribution.
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