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检索条件"主题词=Bnip3"
514 条 记 录,以下是101-110 订阅
排序:
Mst1 regulates colorectal cancer stress response via inhibiting bnip3-related mitophagy by activation of JNK/p53 pathway
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CELL BIOLOGY AND TOXICOLOGY 2018年 第4期34卷 263-277页
作者: Li, Qi Qi, Feng Meng, Xiangchao Zhu, Chenpei Gao, Yingtang Tianjin Med Univ Dept Gen Surg Cent Clin Coll 3 Tianjin 300170 Peoples R China Tianjin Med Univ Gen Hosp Dept Gen Surg Tianjin 300052 Peoples R China Tianjin Third Cent Hosp Tianjin Key Lab Artificial Cell 83 Jintang Rd Tianjin 300170 Peoples R China
The Hippo-Mst1 pathway is associated with tumor development and progression. However, little evidence is available for its role in colorectal cancer (CRC) stress response via mitochondrial homeostasis. In this study, ... 详细信息
来源: 评论
FOXO3a regulates bnip3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress
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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2016年 第6期311卷 H1540-H1559页
作者: Chaanine, Antoine H. Kohlbrenner, Erik Gamb, Scott I. Guenzel, Adam J. Klaus, Katherine Fayyaz, Ahmed U. Nair, K. Sreekumaran Hajjar, Roger J. Redfield, Margaret M. Mayo Clin Div Cardiovasc Dis 200 First St SW Rochester MN 55905 USA Mt Sinai Sch Med Div Cardiovasc Dis New York NY USA Mayo Clin Dept Biochem & Cell Biol Microscopy & Cell Anal Core 200 First St SW Rochester MN 55905 USA Mayo Clin Div Endocrinol 200 First St SW Rochester MN 55905 USA
The forkhead box O3a (FOXO3a) transcription factor has been shown to regulate glucose metabolism, muscle atrophy, and cell death in postmitotic cells. Its role in regulation of mitochondrial and myocardial function is... 详细信息
来源: 评论
Localization and developmental ontogeny of the pro-apoptotic bnip3 mRNA in the postnatal rat cortex and hippocampus
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BRAIN RESEARCH 2006年 第1期1100卷 55-63页
作者: Sandau, Ursula S. Handa, Robert J. Colorado State Univ Dept Biomed Sci Ft Collins CO 80523 USA
Naturally occurring cell death occurs during the first two postnatal weeks in the rat cortex and hippocampus. During this process, apoptosis is initiated by activating or altering expression of pro-apoptotic members o... 详细信息
来源: 评论
Hypoxia induces the expression of the pro-apoptotic gene bnip3
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CELL DEATH AND DIFFERENTIATION 2001年 第4期8卷 367-376页
作者: Guo, K Searfoss, G Krolikowski, D Pagnoni, M Franks, C Clark, K Yu, KT Jaye, M Ivashchenko, Y AVENTIS PHARMA Cardiovasc Biol D-65926 Frankfurt Germany
It has been shown that oxygen deprivation results in apoptotic cell death, and that hypoxia inducible factor 1 (HIF1) and the tumor suppressor p53 play key roles in this process. However, the molecular mechanism throu... 详细信息
来源: 评论
Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting bnip3
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DRUG DESIGN DEVELOPMENT AND THERAPY 2016年 第20160215期10卷 631-647页
作者: Li, Sainan Xia, Yujing Chen, Kan Li, Jingjing Liu, Tong Wang, Fan Lu, Jie Zhou, Yingqun Guo, Chuanyong Tongji Univ Sch Med Shanghai Peoples Hosp 10 Dept Gastroenterol Shanghai 200072 Peoples R China
Background: Epigallocatechin-3-gallate (EGCG) is the most effective compound in green tea, and possesses a wide range of beneficial effects, including anti-inflammatory, antioxidant, antiobesity, and anticancer effect... 详细信息
来源: 评论
Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and bnip3
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CELLULAR AND MOLECULAR LIFE SCIENCES 2005年 第9期62卷 1015-1024页
作者: Gao, S Fu, W Dürrenberger, M De Geyter, C Zhang, H Univ Basel Dept Res CH-4031 Basel Switzerland Univ Basel Univ Womens Hosp CH-4031 Basel Switzerland Univ Zurich Hosp Med Res Ctr CH-8091 Zurich Switzerland Univ Basel Bioctr CH-4031 Basel Switzerland
hBok is a human pro-apoptotic member of the Bcl-2 family. By fluorescence in situ hybridization and in silico analysis, hBok was found to be located on chromosome 2q37.3. Its expression was detected in various organs ... 详细信息
来源: 评论
Ellagic acid antagonizes bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes
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FREE RADICAL BIOLOGY AND MEDICINE 2017年 112卷 411-422页
作者: Dhingra, Abhinav Jayas, Rahul Afshar, Pegah Guberman, Matthew Maddaford, Graham Gerstein, Johnathan Lieberman, Brooke Nepon, Hilary Margulets, Victoria Dhingra, Rimpy Kirshenbaum, Lorrie A. St Boniface Gen Hosp Albrechtsen Res Ctr Dept Physiol & Pathophysiol Inst Cardiovasc Sci Winnipeg MB Canada Univ Manitoba Coll Med Fac Hlth Sci Winnipeg MB R2H 2H6 Canada
The Bcl-2 protein bnip3 is crucial for provoking oxidative injury to mitochondria following anthracycline treatment or ischemia-reperfusion injury. Herein, we investigate the effects of the polyphenolic compound ellag... 详细信息
来源: 评论
The HIF1α-inducible pro-cell death gene bnip3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element
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ONCOGENE 2009年 第41期28卷 3671-3680页
作者: Farrall, A. L. Whitelaw, M. L. Univ Adelaide Discipline Biochem Sch Mol & Biomed Sci Adelaide SA 5005 Australia Ctr Mol Genet Dev Adelaide SA Australia
The short isoform of single-minded 2 (SIM2s), a basic helix-loop-helix/PAS (bHLH/PAS) transcription factor, is upregulated in pancreatic and prostate tumours;however, a mechanistic role for SIM2s in these cancers is u... 详细信息
来源: 评论
Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced bnip3 expression
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GROWTH FACTORS 2016年 第3-4期34卷 73-86页
作者: Feng, Chih-Chung Lin, Chien-Chung Lai, Yi-Ping Chen, Tung-Sheng Asokan, Shibu Marthandam Lin, Jing-Ying Lin, Kuan-Ho Viswanadha, Vijaya Padma Kuo, Wei-Wen Huang, Chih-Yang China Med Univ Grad Inst Clin Med Sci Grad Inst Basic Med Sci Taichung Taiwan Armed Forces Gen Hosp Dept Orthopaed Taichung Taiwan China Med Univ Grad Inst Basic Med Sci Taichung Taiwan China Med Univ Hosp Biomat Translat Res Ctr Taichung Taiwan Cent Taiwan Univ Sci & Technol Dept Nursing Taichung Taiwan China Med Univ Hosp Emergency Dept Taichung Taiwan Bharathiar Univ Dept Biotechnol Coimbatore Tamil Nadu India China Med Univ Dept Biol Sci & Technol Taichung Taiwan China Med Univ Grad Inst Chinese Med Sci Taichung Taiwan Asia Univ Dept Hlth & Nutr Biotechnol Taichung Taiwan
The HIF-1 alpha transcriptional factor and the BH-3 only protein bnip3 are known to play fundamental roles in response to hypoxia. The objective of this research is to investigate the molecular mechanisms and the corr... 详细信息
来源: 评论
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via bnip3/LC3 signaling mediated autophagy
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BRAIN RESEARCH BULLETIN 2022年 第0期180卷 12-23页
作者: Luo, Jing Tan, Junyi Jiang, Ning Yang, Changhong Chen, Jialei Zhao, Jing Li, Lingyu Zhao, Yong Chongqing Med Univ Dept Pathol Chongqing 400016 Peoples R China Chongqing Med Univ Dept Pathophysiol Chongqing 400016 Peoples R China Chongqing Med Univ Dept Bioinformat Chongqing 400016 Peoples R China Chongqing Med Univ Inst Neurosci Chongqing 400016 Peoples R China
Studies have found that Platonin has neuroprotective effect, but its molecular mechanism needs further study. We found that at the early stage of cerebral ischemia/reperfusion injury, Platonin treatment significantly ... 详细信息
来源: 评论